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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Consilium Medicum</journal-id><journal-title-group><journal-title xml:lang="en">Consilium Medicum</journal-title><trans-title-group xml:lang="ru"><trans-title>Consilium Medicum</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Consilium Medicum</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-1753</issn><issn publication-format="electronic">2542-2170</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">108443</article-id><article-id pub-id-type="doi">10.26442/20751753.2022.2.201512</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">COVID-associated cognitive impairments: A review</article-title><trans-title-group xml:lang="ru"><trans-title>COVID-ассоциированные когнитивные нарушения</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9097-898X</contrib-id><name-alternatives><name xml:lang="en"><surname>Preobrazhenskaya</surname><given-names>Irina S.</given-names></name><name xml:lang="ru"><surname>Преображенская</surname><given-names>Ирина Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.), Prof., Sechenov First Moscow State Medical University (Sechenov University)</p></bio><bio xml:lang="ru"><p>д-р мед. наук, проф. каф. нервных болезней и нейрохирургии ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)</p></bio><email>irinasp2@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Sechenov First Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2022</year></pub-date><volume>24</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>96</fpage><lpage>102</lpage><history><date date-type="received" iso-8601-date="2022-06-01"><day>01</day><month>06</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-06-01"><day>01</day><month>06</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://consilium.orscience.ru/2075-1753/article/view/108443">https://consilium.orscience.ru/2075-1753/article/view/108443</self-uri><abstract xml:lang="en"><p>The COVID-19 pandemic, caused by the SARS-CoV-2 virus, began in March 2020 and continues to the present. The virus most often affects the respiratory system; to date, there is evidence of possible damage to the heart, skin, kidneys, central nervous system in this disease. In this regard, it is of great interest to study the neurological features of COVID-19, in particular, the development of cognitive disorders or the increase in the severity of already existing cognitive impairments. This review provides the latest data on the relationship of COVID-19 and cognitive impairment, the proposed etiology, pathogenesis and main clinical manifestations of cognitive disorders, and also discusses possible strategies for the treatment of cognitive impairment after suffering COVID-19.</p></abstract><trans-abstract xml:lang="ru"><p>Пандемия COVID-19, вызванная вирусом SARS-CoV-2, началась в марте 2020 г. и продолжается по настоящее время. Вирус чаще всего поражает дыхательную систему; на сегодняшний день есть данные о возможном поражении сердца, кожи, почек, центральной нервной системы при этом заболевании. В связи с этим большой интерес представляет изучение неврологических особенностей COVID-19, в основном – развития когнитивных расстройств или усиления выраженности уже существующих когнитивных нарушений. В настоящем обзоре приводятся последние данные о взаимосвязи COVID-19 и когнитивных нарушений, предположительная этиология, патогенез и основные клинические проявления когнитивных расстройств, а также обсуждаются возможные стратегии лечения когнитивных нарушений после перенесенного COVID-19.</p></trans-abstract><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>cognitive impairment</kwd><kwd>elderly patients</kwd><kwd>MoCa</kwd><kwd>MMSE</kwd><kwd>executive functions</kwd><kwd>fatigue</kwd><kwd>emotional disturbances</kwd><kwd>depression</kwd><kwd>endothelial dysfunction</kwd><kwd>vascular cognitive impairment</kwd><kwd>Alzheimer's disease</kwd><kwd>mild cognitive impairment</kwd><kwd>treatment</kwd><kwd>nicergoline</kwd><kwd>sermion</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>когнитивные нарушения</kwd><kwd>пожилые пациенты</kwd><kwd>МоСа</kwd><kwd>MMSE</kwd><kwd>управляющие функции</kwd><kwd>усталость</kwd><kwd>эмоциональные нарушения</kwd><kwd>депрессия</kwd><kwd>эндотелиальная дисфункция</kwd><kwd>сосудистые когнитивные нарушения</kwd><kwd>болезнь Альцгеймера</kwd><kwd>умеренные когнитивные расстройства</kwd><kwd>лечение</kwd><kwd>ницерголин</kwd><kwd>сермион</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Tarantola D, Dasgupta N. COVID-19 Surveillance Data: A Primer for Epidemiology and Data Science. Am J Public Health. 2021;111(4):614-9. DOI:10.2105/AJPH.2020.306088</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Wu Z, McGoogan JM. Characteristics of and important lessons from the Coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese center for disease control and prevention. JAMA. 2020;323:1239-42. DOI:10.1001/jama.2020.2648</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Tsai ST, Lu MK, San S, Tsai CH. The neurologic manifestations of Coronavirus disease 2019 pandemic: a systemic review. Front Neurol. 2020;11:498. DOI:10.3389/fneur.2020.00498</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Pinzon RT, Wijaya VO, Buana RB, et al. Neurologic characteristics in Coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis. Front Neurol. 2020;11:565. DOI:10.3389/fneur.2020.00565</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Pajo AT, Espiritu AI, Apor ADAO, Jamora RDG. Neuropathologic findings of patients with COVID-19: a systematic review. Neurol Sci. 2021;42(4):1255-66. DOI:10.1007/s10072-021-05068-7</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Kantonen J, Mahzabin S, Mäyränpää MI, et al. Neuropathologic features of four autopsied COVID-19 patients. Brain Pathol. 2020;30(6):1012-6. DOI:10.1111/bpa.12889</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Fabbri VP, Foschini MP, Lazzarotto T, et al. Brain ischemic injury in COVID-19-infected patients: a series of 10 post-mortem cases. Brain Pathol. 2021;31(1):205-10. DOI:10.1111/bpa.12901</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Solomon IH, Normandin E, Bhattacharyya S, et al. Neuropathological Features of COVID-19. N Engl J Med. 2020;383(10):989. DOI:10.1056/NEJMc2019373</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Matschke J, Lütgehetmann M, Hagel C, et al. Neuropathology of patients with COVID-19 in Germany: a post-mortem case series. Lancet Neurol. 2020;19(11):919-29. DOI:10.1016/S1474-4422(20)30308-2</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Gu J, Gong E, Zhang B, et al. Multiple organ infection and the pathogenesis of SARS. J Exp Med. 2005;202(3):415-24. DOI:10.1084/jem.20050828</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Bodro M, Compta Y, Sánchez-Valle R. Presentations and mechanisms of CNS disorders related to COVID-19. Neurol Neuroimmunol Neuroinflamm. 2021;8(1):e923. DOI:10.1212/NXI.0000000000000923</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Parra JED, Montoya DD, Peláez FJC. COVID-19 also Affects the Nervous System by One of its Gates: The Vascular Organ of Lamina Terminalis and the Olfactory Nerve. Neurological Alert, Dysosmia or Anosmia Test Can Help to A Quick Diagnosis. Int J Odontostomat. 2020;14(3):285-7. DOI:10.4067/S0718-381X2020000300285</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Jiao L, Yang Y, Yu W, et al. The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys. Sig Transduct Target Ther. 2021;6:169. DOI:10.1038/s41392-021-00591-7</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Frontera JA, Boutajangout A, Masurkar AV, et al. Comparison of serum neurodegenerative biomarkers among hospitalized COVID-19 patients versus non-COVID subjects with normal cognition, mild cognitive impairment, or Alzheimer’s dementia. Alzheimer’s Dement. 2022;89(3):610-6. DOI:10.1002/alz.12556</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Sutter R, Hert L, De Marchis GM, et al. Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019. Ann Neurol. 2021;89(3):610-6. DOI:10.1002/ana.26004</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Aamodt AH, Høgestøl EA, Popperud TH, et al. Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19. J Neurol. 2021;268(10):3574-83. DOI:10.1007/s00415-021-10517-6</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Prudencio M, Erben Y, Marquez CP, et al. Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19. Sci Transl Med. 2021;13. DOI:10.1126/scitranslmed.abi7643</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Sun B, Tang N, Peluso MJ, et al. Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations. Cells. 2021;10(2):386. DOI:10.3390/cells10020386</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Altuna M, Sánchez-Saudinós MD, Lleó A. Cognitive symptoms after COVID-19. Neurology perspectives. 2021;1:16-24. DOI:10.1016/j.neurop.2021.10.005</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Vanderlind WM, Rabinovitz BB, Miao IY, et al. A systematic review of neuropsychological and psychiatric sequalae of COVID-19: implications for treatment. Curr Opin Psychiatry. 2021;34:420-33. DOI:10.1097/YCO.0000000000000713</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Almeria M, Cejudo JC, Sotoca J, et al. Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment. Brain Behav Immun Health. 2020;9:100163. DOI:10.1016/j.bbih.2020.100163</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Helms J, Kremer S, Merdji H, et al. Neurologic Features in Severe SARS-CoV-2 Infection. N Engl J Med. 2020;382(23):2268-70. DOI:10.1056/NEJMc2008597</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Zhou H, Lu S, Chen J, et al. The landscape of cognitive function in recovered COVID-19 patients. J Psychiatr Res. 2020;129:98-102. DOI:10.1016/j.jpsychires.2020.06.022</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Townsend L, Dyer AH, Jones K, et al. Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection. PLoS One. 2020;15:e0240784. DOI:10.1371/journal.pone.0240784</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Poyiadji N, Shahin G, Noujaim D, et al. COVID-19–associated Acute Hemorrhagic Necrotizing Encephalopathy: Imaging Features. Radiology. 2020;296(2):E119-20. DOI:10.1148/radiol.2020201187</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Moriguchi T, Harii N, Goto J, et al. A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. Int J Infect Dis. 2020;94:55-8. DOI:10.1016/j.ijid.2020.03.062</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Oxley TJ, Mocco J, Majidi S, et al. Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young. N Engl J Med. 2020;382:e60. DOI:10.1056/NEJMc2009787</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Lyden P. Temporary Emergency Guidance to US Stroke Centers During the Coronavirus Disease 2019 (COVID-19) Pandemic. Stroke. 2020;51(6):1910-2. DOI:10.1161/STROKEAHA.120.030023</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Ntaios G, Pearce LA, Veltkamp R, et al. Potential Embolic Sources and Outcomes in Embolic Stroke of Undetermined Source in the NAVIGATE-ESUS Trial. Stroke. 2020;51(6):1797-804. DOI:10.1161/STROKEAHA.119.028669</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Ahmadi Karvigh S, Vahabizad F, Banihashemi G, et al. Ischemic Stroke in Patients with COVID-19 Disease: A Report of 10 Cases from Iran. Cerebrovasc Dis. 2021;50(2):239-44. DOI:10.1159/000513279</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Cavallieri F, Marti A, Fasano A, et al. Prothrombotic state induced by COVID-19 infection as trigger for stroke in young patients: A dangerous association. eNeurologicalSci. 2020;20:100247. DOI:10.1016/j.ensci.2020.100247</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Crivelli L, Palmer K, Calandri I, et al. Changes in cognitive functioning after COVID-19: A systematic review and meta-analysis. Alzheimer’s Dement. 2022;4(10):e2130645. DOI:10.1002/alz.12644</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Becker JH, Lin JJ, Doernberg M, et al. Assessment of Cognitive Function in Patients After COVID-19 Infection. JAMA Netw Open. 2021;4(10):e2130645. DOI:10.1001/jamanetworkopen.2021.30645</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Hampshire A, Trender W, Chamberlain SR, et al. Cognitive deficits in people who have recovered from COVID-19. E Clinical Medicine. 2021;39:101044. DOI:10.1016/j.eclinm.2021.101044</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Alonso-Lana S, Marquié M, Ruiz A, Boada M. Cognitive and Neuropsychiatric Manifestations of COVID-19 and Effects on Elderly Individuals with Dementia. Front Aging Neurosci. 2020;12:588872. DOI:10.3389/fnagi.2020.588872</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>de Graaf MA, Antoni ML, Ter Kuile MM, et al. Short-term outpatient follow-up of COVID-19 patients: a multidisciplinary approach. E Clinical Medicine. 2021;32:100731. DOI:10.1016/j.eclinm.2021.100731</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Ceban F, Ling S, Lui LMW, et al. Fatigue and cognitive impairment in post-COVID-19 Syndrome: A systematic review and meta-analysis. Brain Behav Immun. 2022;101:93-135. DOI:10.1016/j.bbi.2021.12.020</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Stallmach A, Kesselmeier M, Bauer M, et al. Comparison of fatigue, cognitive dysfunction and psychological disorders in post-COVID patients and patients after sepsis: is there a specific constellation? Infection. 2022;46:39-48. DOI:10.1007/s15010-021-01733-3</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Miskowiak K, Johnsen S, Sattler S, et al. Cognitive impairments four months after COVID-19 hospital discharge: Pattern, severity and association with illness variables. Eur Neuropsychopharmacol. 2021;46:39-48. DOI:10.1016/j.euroneuro.2021.03.019</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Huang C, Huang L, Wang Y, et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. The Lancet. 2021;397:220-32. DOI:10.1016/S0140-6736(20)32656-8</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Serrano-Castro PJ, Garzón-Maldonado FJ, Casado-Naranjo I, et al. The cognitive and psychiatric subacute impairment in severe Covid-19. Sci Rep. 2022;12:3563. DOI:10.1038/s41598-022-07559-9</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Undurraga EA, Chowell G, Mizumoto K. COVID-19 case fatality risk by age and gender in a high testing setting in Latin America: Chile, March–August 2020. Infect Dis Poverty. 2021;10:11. DOI:10.1186/s40249-020-00785-1</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Goujon A, Natale F, Ghio D, et al. Age, gender, and territory of COVID-19 infections and fatalities. Luxembourg: Publications Office of the European Union, 2020. DOI:10.2760/838390</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Atkins JL, Masoli JAH, Delgado J, et al. Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort. The Journals of Gerontology. 2020;75(11):2224-30. DOI:10.1093/gerona/glaa183</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Owolabi LF, Raafat A, Enwere OO, et al. Hemorrhagic infarctive stroke in COVID-19 patients: report of two cases and review of the literature. J Community Hosp Intern Med Perspect. 2021;11(3):322-6. DOI:10.1080/20009666.2021.1883814</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Nalugo M, Schulte LJ, Masood MF, Zayed MA. Microvascular Angiopathic Consequences of COVID-19. Front Cardiovasc Med. 2021;8:26. DOI:10.3389/fcvm.2021.636843</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Lara B, Carnes A, Dakterzada F, et al. Neuropsychiatric symptoms and quality of life in Spanish patients with Alzheimer’s disease during the COVID-19 lockdown. Eur J Neurol. 2020;27:1744-7. DOI:10.1111/ene.14339</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Nakamura ZM, Nash RP, Laughon SL, Rosenstein DL. Neuropsychiatric Complications of COVID-19. Curr Psychiatry Rep. 2021;23(5):25. DOI:10.1007/s11920-021-01237-9</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Iodice F, Cassano V, Rossini PM. Direct and indirect neurological, cognitive, and behavioral effects of COVID-19 on the healthy elderly, mild-cognitive-impairment, and Alzheimer’s disease populations. Neurol Sci. 2021;42(2):455-65. DOI:10.1007/s10072-020-04902-8</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Miners S, Kehoe PG, Love S. Cognitive impact of COVID-19: looking beyond the short term. Alzheimers Res Ther. 2020;12(1):170. DOI:10.1186/s13195-020-00744-w</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Fotuhi M, Mian A, Meysami S, Raji CA. Neurobiology of COVID-19. J Alzheimer’s Dis. 2020;76:3-19. DOI:10.3233/JAD-200581</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Wang F, Kream RM, Stefano GB. Long-Term Respiratory and Neurological Sequelae of COVID-19. Med Sci Monit. 2020;26(7):4016-26. DOI:10.12659/MSM.928996</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Kuo CL, Pilling LC, Atkins JL, et al. APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort. The Journals of Gerontology. 2020;75(11):2231-2. DOI:10.1093/gerona/glaa131</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Douaud G, Lee S, Alfaro-Almagro F, et al. Brain imaging before and after COVID-19 in UK Biobank. medRxiv Prepr Serv Heal Sci. 2021;06(11). DOI:10.1101/2021.06.11.21258690</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Государственный реестр лекарственных средств Минздрава России. Режим доступа: https://grls.rosminzdrav.ru. Ссылка активна на 25.03.2022. [Gosudarstvennyi reestr lekarstvennykh sredstv Minzdrava Rossii. Available at: https://grls.rosminzdrav.ru. Accessed: 25.03.2022 (in Russian)].</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Остроумова О.Д., Кочетков А.И., Остроумова Т.М., Клепикова М.В. Потенциал ницерголина в условиях полиморбидности и когнитивных нарушений (клинический пример). Медицинский алфавит. 2020;1(19):11-8 [Ostroumova OD, Kochetkov AI, Ostroumova TM, Klepikova MV. Potential of nicergoline in polymorbidity and cognitive impairment (clinical case). Medical alphabet. 2020;1(19):11-8 (in Russian)]. DOI:10.33667/2078-5631-2020-19-11-18</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Fioravanti M, Flicker L. Nicergoline for dementia and other age associated forms of cognitive impairment. Cochrane Database Syst Rev. 2001;4. DOI:10.1002/14651858.CD003159</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>Fioravanti M, Nakashima T, Xu J, Garg A. A systematic review and meta-analysis assessing adverse event profile and tolerability of nicergoline. BMJ Open. 2014;4(7):e005090. DOI:10.1136/bmjopen-2014-005090</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>Boulu P. Effects du Sermion® sur les troubles mn.esiques et les fonctions de la vie de relation. Tempo medical. 1990;397:24-7.</mixed-citation></ref><ref id="B60"><label>60.</label><mixed-citation>Sibilio P, Bini S, Fiscon G, et al. In silico drug repurposing in COVID-19: A network-based analysis. Biomed Pharmacother. 2021;142:111954. DOI:10.1016/j.biopha.2021.111954</mixed-citation></ref><ref id="B61"><label>61.</label><mixed-citation>Rose L, Graham L, Koenecke A, et al. The Association Between Alpha-1 Adrenergic Receptor Antagonists and In-Hospital Mortality From COVID-19. Front Med. 2021;8. DOI:10.3389/fmed.2021.637647</mixed-citation></ref><ref id="B62"><label>62.</label><mixed-citation>Luo P, Liu D, Li J. Epinephrine use in COVID-19: friend or foe? Eur J Hosp Pharm. 2021;28(1):e1. DOI:10.1136/ejhpharm-2020-002295</mixed-citation></ref><ref id="B63"><label>63.</label><mixed-citation>Navan C. Possible Drug Candidates for COVID-19. chemRxiv. 2020. Available at: https://chemrxiv.org/articles/Possible_Drug_Candidates_for_COVID-19/11985231. Accessed: 25.03.2022.</mixed-citation></ref><ref id="B64"><label>64.</label><mixed-citation>Rejdak K, Karbowniczek A, Białecka M, et al. Treatment in post-COVID syndrome – nicergoline as the therapeutic potential in reduction symptoms of COVID brain fog. Medycyna Faktów. 2021;14:294-302. DOI:10.24292/01.MF.0321.12</mixed-citation></ref><ref id="B65"><label>65.</label><mixed-citation>Ikemoto K. Multi-Particulate High Intensity of Brain MRI in 30’s Male Heavy Smoker Suicidal Attempt Case following Mild COVID-19 Pneumonia. Adv Case Stud. 2021;3(2):e1. DOI:10.31031/AICS.2021.03.000558</mixed-citation></ref></ref-list></back></article>
