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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Consilium Medicum</journal-id><journal-title-group><journal-title xml:lang="en">Consilium Medicum</journal-title><trans-title-group xml:lang="ru"><trans-title>Consilium Medicum</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Consilium Medicum</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-1753</issn><issn publication-format="electronic">2542-2170</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">109884</article-id><article-id pub-id-type="doi">10.26442/20751753.2022.6.201769</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Personalized approach in the treatment of thyroid cancer: A review</article-title><trans-title-group xml:lang="ru"><trans-title>Персонализированный подход в лечении рака щитовидной железы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6895-0497</contrib-id><name-alternatives><name xml:lang="en"><surname>Radzhabova</surname><given-names>Zamira Ah.-G.</given-names></name><name xml:lang="ru"><surname>Раджабова</surname><given-names>Замира Ахмед-Гаджиевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.), Assoc. Prof.</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доц., зав. хирургическим отд-нием опухолей головы и шеи, науч. сотр., врач-онколог</p></bio><email>radzam@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Petrov National Medicine Research Center of Oncology</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2022</year></pub-date><volume>24</volume><issue>6</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>412</fpage><lpage>415</lpage><history><date date-type="received" iso-8601-date="2022-08-15"><day>15</day><month>08</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-08-15"><day>15</day><month>08</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://consilium.orscience.ru/2075-1753/article/view/109884">https://consilium.orscience.ru/2075-1753/article/view/109884</self-uri><abstract xml:lang="en"><p>The main goal is to improve treatment outcomes of disseminated inoperable thyroid cancer through a personalized choice of targeted agents. Considering gene mutations in drug choice will further improve the survival of patients with rare mutations. Despite the small sample of patients, mutation detection, regardless of localization, and basket studies will allow future results to be obtained much faster than in a dozen years and use these results in this rare category of patients. Basket studies allow patients with rare disorders to receive personalized therapy according to mutations in tumor tissue, regardless of the affected organ.</p></abstract><trans-abstract xml:lang="ru"><p>Основной целью работы является улучшение результатов лечения диссеминированного неоперабельного рака щитовидной железы путем персонализированного подбора таргетных препаратов. Знание генных мутаций при выборе препарата позволит в дальнейшем улучшить выживаемость пациентов с редкими мутациями. Несмотря на небольшую выборку пациентов, определение мутации вне зависимости от локализации и корзинные исследования позволят в будущем не дожидаться результатов на протяжении десятка лет, а использовать результаты терапии в настоящий момент у редкой категории пациентов. Корзинные исследования дают возможность редким пациентам персонализированно подобрать препарат относительно мутаций в опухолевой ткани, независимо от пораженного органа.</p></trans-abstract><kwd-group xml:lang="en"><kwd>gene mutations</kwd><kwd>personalized therapy</kwd><kwd>biomarkers</kwd><kwd>NTRK-mutations</kwd><kwd>RET-mutations</kwd><kwd>basket studies</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>генные мутации</kwd><kwd>персонализированная терапия</kwd><kwd>биомаркеры</kwd><kwd>NTRK-мутации</kwd><kwd>RET-мутации</kwd><kwd>корзинные исследования</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Дифференцированный рак щитовидной железы. Рубриктор клинических рекомендаций. 2020. Режим доступа: https://cr.minzdrav.gov.ru/recomend/329_1/ Ссылка активна на 15.05.2022 [Differentsirovannyi rak shchitovidnoi zhelezy. Rubriktor klinicheskikh rekomendatsii. 2020. 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