Consilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum11753710.26442/20751753.2022.10.201875Review ArticleCombination therapy of newly diagnosed intermediate-risk pulmonary arterial hypertension: A reviewLyapinaIrina N.<p>Cand. Sci. (Med.), Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo State Medical University</p>zaviirina@mail.ruhttps://orcid.org/0000-0002-4649-5921ZverevaTatiana N.<p>Cand. Sci. (Med.), Assoc. Prof., Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo State Medical University</p>zverevat25@mail.ruhttps://orcid.org/0000-0002-2233-2095MartynyukTamila V.<p>D. Sci. (Med.), Chazov National Medical Research Center of Cardiology, Pirogov Russian National Research Medical University</p>trukhiniv@mail.ruResearch Institute for Complex Issues of Cardiovascular DiseasesKemerovo State Medical UniversityChazov National Medical Research Center of CardiologyPirogov Russian National Research Medical University1510202224106886951412202214122022Copyright © 2022, Consilium Medicum2022<p>Advancements in the specific therapy of pulmonary arterial hypertension (PAH) and new combination therapy strategies and escalation treatment over the past decade have significantly improved disease control, slowed its progression, and improved quality of life and patient survival. This review provides a detailed discussion of current strategies for PAH-specific therapy available in the Russian Federation for patients with classical and non-classical PAH who fail to achieve treatment goals and remain at intermediate risk of disease progression/mortality.</p>pulmonary arterial hypertensionintermediate risk of mortalityPAH-specific therapyinitial combination therapyлегочная артериальная гипертензияпромежуточный риск летальностиЛАГ-специфическая терапияначальная комбинированная терапия[Авдеев С.Н., Барбараш О.Л., Баутин А.Е., и др. Легочная гипертензия, в том числе хроническая тромбоэмболическая легочная гипертензия. Клинические рекомендации 2020. Российский кардиологический журнал. 2021;26(12):4683 [Avdeev SN, Barbarash OL, Bautin AE, et al. Clinical practice guidelines for Pulmonary hypertension, including chronic thromboembolic pulmonary hypertension. Russian Journal of Cardiology. 2021;26(12):4683 (in Russian)]. 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