Consilium MedicumConsilium MedicumConsilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum12022410.26442/20751753.2022.11.202022ArticlesСтатьиReview ArticleThe effect of sleep on the normal functioning of the prostate gland: A reviewВлияние сна на структурно-функциональное состояние предстательной железыhttps://orcid.org/0000-0001-5758-85522059-3248ErshovAnton V.ЕршовАнтон Валерьевич
Russian Federation

D. Sci. (Med.)

д-р мед. наук, проф. каф. патофизиологии; вед. науч. сотр.

salavatprof@mail.ruhttps://orcid.org/0000-0003-0595-4199GroshevaMariia N.ГрошеваМария Николаевна
Russian Federation

Student

студентка

de.Mariya.co@yandex.ruhttps://orcid.org/0000-0003-4253-701XStepanyantsSona V.СтепанянцСона Вазгеновна
Russian Federation

Student

студентка

step_sw@mail.ruYakovlevAndrei V.ЯковлевАндрей Владимирович
Russian Federation

Cand. Sci. (Med.)

канд. мед. наук, врач-уролог

andryakovlev81@mail.ruSechenov First Moscow State Medical University (Sechenov University)ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)Negovsky Scientific Research Institute of General Reanimatology of the Federal Research and Clinical Center of Intensive Care Medicine and RehabilitologyНаучно-исследовательский институт общей реаниматологии им. В.А. Неговского ФГБНУ «Федеральный научно-клинический центр реаниматологии и реабилитологии» РАНClinical Diagnostic Center “Doctor Kulik’s Clinic”ООО «Клинико-диагностический центр “Клиника Доктора Кулик“»1511202224118168210501202305012023Copyright ©; 2022, Consilium MedicumCopyright ©; 2022, ООО "Консилиум Медикум"2022Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://consilium.orscience.ru/2075-1753/article/view/120224

The article provides an analysis of current information on the effect of sleep, namely its main element, melatonin, on the functioning of the prostate gland. The direct action of melatonin as a local modulator of the endocrine activity of Sertoli and Leydig cells and its effect on energy metabolism are described. The main biochemical antioxidant properties of melatonin are reflected, as well as the mechanisms of its action on the hormonal system of the body: metabolism, fertility and anticarcinogenicity. The results of studies on the relationship between sleep disorders, the role of the circadian rhythm in fertility disorders and prostate diseases are disclosed. The relationship between the presence of metabolic syndrome and the subsequent risk of developing benign prostatic hyperplasia is presented.

В статье приводится анализ актуальной информации о влиянии сна, его нарушения и стресса, смены циркадных ритмов на структурно-функциональное состояние предстательной железы. Описано прямое действие мелатонина как локального модулятора эндокринной активности клеток Сертоли и Лейдига и влияние на энергетический обмен. Отражены основные биохимические антиоксидантные свойства мелатонина, а также механизмы его действия на гормональную систему организма: метаболизм, фертильность и антиканцерогенность. Раскрыты результаты исследований по взаимосвязи нарушения сна, роли циркадного ритма в нарушении фертильности и заболеваний предстательной железы. Представлена связь между наличием метаболического синдрома и последующим риском развития доброкачественной гиперплазии предстательной железы.

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