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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Consilium Medicum</journal-id><journal-title-group><journal-title xml:lang="en">Consilium Medicum</journal-title><trans-title-group xml:lang="ru"><trans-title>Consilium Medicum</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Consilium Medicum</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-1753</issn><issn publication-format="electronic">2542-2170</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">567840</article-id><article-id pub-id-type="doi">10.26442/20751753.2023.5.202221</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Chronic pancreatitis: prospects for early detection: A review</article-title><trans-title-group xml:lang="ru"><trans-title>Хронический панкреатит: перспективы раннего выявления</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ledeneva</surname><given-names>Ekaterina M.</given-names></name><name xml:lang="ru"><surname>Леденева</surname><given-names>Екатерина Михайловна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Resident</p></bio><bio xml:lang="ru"><p>ординатор каф. терапии, клинической фармакологии и скорой медицинской помощи</p></bio><email>docled@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8975-8608</contrib-id><contrib-id contrib-id-type="spin">9605-9117</contrib-id><name-alternatives><name xml:lang="en"><surname>Vertkin</surname><given-names>Arkadiy L.</given-names></name><name xml:lang="ru"><surname>Верткин</surname><given-names>Аркадий Львович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.), Prof.</p></bio><bio xml:lang="ru"><p>д-р мед. наук, проф., зав. каф. терапии, клинической фармакологии и скорой медицинской помощи, засл. деят. науки России</p></bio><email>kafedrakf@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="spin">2897-5838</contrib-id><name-alternatives><name xml:lang="en"><surname>Sediakina</surname><given-names>Iuliia V.</given-names></name><name xml:lang="ru"><surname>Седякина</surname><given-names>Юлия Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доц. каф. терапии, клинической фармакологии и скорой медицинской помощи</p></bio><email>sedyakinayulia@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kurdjieva</surname><given-names>Svetlana S.</given-names></name><name xml:lang="ru"><surname>Курджиева</surname><given-names>Светлана Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Assistant</p></bio><bio xml:lang="ru"><p>ассистент каф. терапии, клинической фармакологии и скорой медицинской помощи</p></bio><email>docled@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="spin">7201-2830</contrib-id><name-alternatives><name xml:lang="en"><surname>Shamuilova</surname><given-names>Marina M.</given-names></name><name xml:lang="ru"><surname>Шамуилова</surname><given-names>Марина Миировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>D. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>д-р мед. наук, проф. каф. терапии, клинической фармакологии и скорой медицинской помощи</p></bio><email>kafedrakf@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Yevdokimov Moscow State University of Medicine and Dentistry</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-05-15" publication-format="electronic"><day>15</day><month>05</month><year>2023</year></pub-date><volume>25</volume><issue>5</issue><issue-title xml:lang="en">Gastroenterology</issue-title><issue-title xml:lang="ru">Гастроэнтерология</issue-title><fpage>308</fpage><lpage>312</lpage><history><date date-type="received" iso-8601-date="2023-07-29"><day>29</day><month>07</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-07-29"><day>29</day><month>07</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://consilium.orscience.ru/2075-1753/article/view/567840">https://consilium.orscience.ru/2075-1753/article/view/567840</self-uri><abstract xml:lang="en"><p>Over the last 10 years, the incidence of chronic pancreatitis (CP) has increased 4 times and nowadays is about 27.4–50 cases per 100 000 adults. In the outpatient gastroenterologist practice, patients with CP account for about 35–45%, in the hospital gastroenterology department – up to 20–45%. CP criteria according to imaging methods – fibrosis, duct dilatation and deformation, calcifications in the pancreatic parenchyma or its atrophy – are formed at a late stage of the disease. Simultaneously, diagnosis at the early stage with potentially reversible changes remains difficult, due to the lack of clear instrumental and laboratory findings confirming minimal changes in the pancreas. However, some methods in combination with a detailed history taking, risk factors identification in comparison with the clinical features are of interest for the early diagnosis of chronic pancreatitis.</p></abstract><trans-abstract xml:lang="ru"><p>За последние 10 лет уровень заболеваемости хроническим панкреатитом (ХП) вырос в 4 раза и насчитывает 27,4–50 случаев на 100 тыс. взрослого населения. В практике амбулаторного врача-гастроэнтеролога больные ХП составляют около 35–45%, в гастроэнтерологическом отделении стационара – до 20–45%. Критерии ХП по данным методов визуализации – фиброз, расширение и деформация протоков, кальцинаты в паренхиме поджелудочной железы или ее атрофия – формируются на поздней стадии заболевания, в то же время диагностика заболевания на стадии с потенциально обратимыми изменениями остается сложной задачей ввиду отсутствия четких диагностических инструментальных и лабораторных маркеров подтверждения минимальных изменений в паренхиме поджелудочной железы. Однако некоторые методы в совокупности с детальным сбором анамнеза, выявлением значимых факторов риска и сопоставлением их с клинической картиной все же представляют собой интерес для ранней диагностики хронического панкреатита.</p></trans-abstract><kwd-group xml:lang="en"><kwd>chronic pancreatitis</kwd><kwd>pancreas</kwd><kwd>M-ANNHEIM</kwd><kwd>early diagnosis</kwd><kwd>acute pancreatitis</kwd><kwd>pain syndrome</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>хронический панкреатит</kwd><kwd>поджелудочная железа</kwd><kwd>M-ANNHEIM</kwd><kwd>ранняя диагностика</kwd><kwd>острый панкреатит</kwd><kwd>болевой синдром</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Маев И.В., Кучерявый Ю.А. Болезни поджелудочной железы. М.: ГЭОТАР–Медиа, 2009 [Maev IV, Kucheriavyi IuA. Bolezni podzheludochnoi zhelezy. 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