Consilium MedicumConsilium MedicumConsilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum62873210.26442/20751753.2024.5.202790ArticlesСтатьиReview ArticleVolatile organic compounds as potential biomarkers for the diagnosis of digestive diseases. A reviewЛетучие органические соединения – потенциальные биомаркеры для диагностики заболеваний органов пищеваренияhttps://orcid.org/0000-0001-5632-1880PilipenkoVladimir I.ПилипенкоВладимир Иванович
Russian Federation

Cand. Sci. (Med.)

канд. мед. наук, науч. сотр. отд-ния гастроэнтерологии и гепатологии

pilipenkowork@rambler.ruFederal Research Centre of Nutrition, Biotechnology and Food SafetyФГБУН «Федеральный исследовательский центр питания, биотехнологии и безопасности пищи»05082024265GastroenterologyГастроэнтерология3033080503202407052024Copyright ©; 2024, Consilium MedicumCopyright ©; 2024, ООО "Консилиум Медикум"2024Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://consilium.orscience.ru/2075-1753/article/view/628732

Diseases of the digestive system are very common among the population around the world. Diagnosis of the diseases of this group is expensive and often invasive, which greatly limits its accessibility to the population. Increasing the time of disease development before diagnosis increases the risk of complications and adverse outcomes. The use of volatile organic compounds (VOC) as a biomarker is becoming increasingly popular due to the accuracy and ease of use. The article examines the available analytical platforms of VOCs for detecting changes in the state of the digestive system, assesses their strengths and weaknesses, provides examples of VOC assessment tool for the diagnosis of certain diseases of the digestive system – inflammatory bowel diseases, colorectal cancer, infectious diarrhea and celiac disease.

Заболевания органов пищеварения отличаются большой распространенностью среди населения всего мира. Диагностика основных заболеваний этой группы дорога и часто инвазивна, что сильно ограничивает ее доступность. Поздняя диагностика повышает риск осложнений и неблагоприятных исходов. Использование летучих органических соединений (ЛОС) в качестве биомаркера становится все более популярным из-за точности и удобства использования. В статье рассмотрены доступные аналитические платформы ЛОС для выявления изменения состояния пищеварительной системы, оценены их сильные и слабые стороны, приведены примеры оценки ЛОС для диагностики некоторых заболеваний органов пищеварения – воспалительных заболеваний кишечника, колоректального рака, инфекционной диареи и целиакии.

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