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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Consilium Medicum</journal-id><journal-title-group><journal-title xml:lang="en">Consilium Medicum</journal-title><trans-title-group xml:lang="ru"><trans-title>Consilium Medicum</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Consilium Medicum</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-1753</issn><issn publication-format="electronic">2542-2170</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">91517</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Primenenie sul'fasalazina v revmatologii</article-title><trans-title-group xml:lang="ru"><trans-title>Применение сульфасалазина в ревматологии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Nasonov</surname><given-names>E. L</given-names></name><name xml:lang="ru"><surname>Насонов</surname><given-names>Е. Л</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ГУ Институт ревматологии РАМН</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2002-08-15" publication-format="electronic"><day>15</day><month>08</month><year>2002</year></pub-date><volume>4</volume><issue>8</issue><issue-title xml:lang="en">VOL 4, NO8 (2002)</issue-title><issue-title xml:lang="ru">ТОМ 4, №8 (2002)</issue-title><fpage>426</fpage><lpage>429</lpage><history><date date-type="received" iso-8601-date="2021-12-28"><day>28</day><month>12</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2002, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2002, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2002</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://consilium.orscience.ru/2075-1753/article/view/91517">https://consilium.orscience.ru/2075-1753/article/view/91517</self-uri><abstract xml:lang="ru"><p>Сульфасалазин представляет собой конъюгат 5-аминосалициловой кислоты и сульфапиридина, обладающих соответственно противовоспалительной и антимикробной активностями, и является первым “базисным” противоревматическим препаратом, который специально разрабатывался для лечения ревматоидного артрита (РА). Побочные эффекты, возникающие на фоне лечения сульфасалазином, подразделяются на идиосинкразические (связанные с гиперчувствительностью или иммуноопосредованные) и зависимые от дозы Тем не менее в целом подавляющее большинство пациентов хорошо переносят лечение сульфасалазином. Переносимость сульфасалазина лучше при приеме препарата с кишечным покрытием.</p></abstract></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1.Amos R.S. Br J Rheumatol 1995; 34:2.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Svartz N. Rheumatism 1948; 4:56.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Sinclair R.J, Duthie J.J. Ann Rheum Dis 1948; 8:226.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Box S.A, Pullar T. Br J Rheumatol 1997; 36:382.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Mc Conkey B, Amos R.S, Durham S et al. 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