Consilium MedicumConsilium MedicumConsilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum93129ArticlesСтатьиResearch ArticleNovyy vzglyad na vozmozhnosti al'fa-lipoevoy kisloty: dokazannaya klinicheskaya effektivnost' i perspektivy (obzor literatury)Новый взгляд на возможности альфа-липоевой кислоты: доказанная клиническая эффективность и перспективы (обзор литературы)StrokovI. AСтроковИ. А

Кафедра нервных болезней

Московская медицинская академия им. И.М.Сеченова15022010122VOL 12, NO2 (2010)ТОМ 12, №2 (2010)899528122021Copyright ©; 2010, Consilium MedicumCopyright ©; 2010, ООО "Консилиум Медикум"2010Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://consilium.orscience.ru/2075-1753/article/view/93129

Альфа-липоевая (тиоктовая) кислота (АЛК) представляет собой естественный коэнзим митохондриального мультиэнзимного комплекса, катализирующего окислительное декарбоксилирование a-кетокислот, таких как пируват и a-кетоглютарат [54]. Структурная формула и свойства АЛК были определены в 1951 г., тогда же начаты клинические исследования эффективности этого вещества при различных заболеваниях. Мощное антиоксидантное действие определило возможности терапевтического использования АЛК [50]. Прежде всего, восстановленная форма АЛК продемонстрировала свойства «ловушки» основного свободного радикала – супероксида. В связи с этим субстанция нашла широкое применение для лечения отравлений металлами и грибами, неалкогольного и алкогольного стеатогепатита, алкогольной полинейропатии. В настоящее время наиболее широко и успешно лекарственная форма АЛК используется в терапии диабетической полинейропатии (ДПН)

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