Consilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum94140Research ArticleMetabolicheskiy sindrom v praktike pediatra i vracha obshchey praktikiZakharovaI. N-ZvenigorodskayaL. A-Vasil'evaS. V-15082014168636628122021Copyright © 2014, Consilium Medicum2014метаболический синдроможирениедислипидемиясахарный диабетинсулинорезистентностьпитаниедисбалансдиетотерапиякоррекция[Reaven G.M. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-607.][Захарова И.Н., Звенигородская Л.А., Малявская С.И. и др. Что нужно педиатру знать о метаболическом синдроме. Часть 1. Cons. Med. Педиатрия (Прил.). 2013; 3: 25-31.][Morrison J.A, Friedman L.A, Gray-Mc-Guire C. Metabolic syndrome in childhood predicts adult cardiovascular disease 25 years later: the Princeton Lipid Research Clinics Follow - up Study. Pediatrics 2007; 120: 340-5.][Черкашова Е.А., Звенигородская Л.А., Самсонова Н.Г., Нилова Т.В., Сильвестрова С.Ю., Хомерики С.Г. Комплексная терапия при атерогенной дислипидемии и неалкогольной жировой болезни печени. CardioСоматика. 2011; 1: 29-36][Wilson P.W, D’Agostino R.B, Parise H et al. Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulation 2005; 112: 3066-72.][Miccoli R, Bianchi C, Odoguardi L et al. Prevalence of the metabolic syndrome among Italian adults according to ATP III definition. Nutr Metab Cardiovasc Dis 2005; 15: 250-4.][Ford E.S, Giles W.H, Dietz W.H. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002; 287: 356-9.][De Ferranti S.D, Gauvreau K, Ludwig D.S et al. Inflammation and changes in metabolic syndrome abnormalities in US adolescents: findings from the 1988-1994 and 1999-2000 National Health and Nutrition Examination Surveys. Clin Chem 2006; 52: 1325-30.][Eun-Gyong Yoo, Sang Shin Park, Sang Woo Oh et al. Strong Parent-Offspring Association of Metabolic Syndrome in Korean Families. Diabetes Care 2012; 35: 293-5.][Feng Y, Zang T, Xu X. Familial aggregation of metabolic syndrome and its components in a large Chinese population. Obesity (Silver Spring) 2008; 16: 125-9.][Schwimmer J.B, Celedon M.A, Lavine J.E et al. Heritability of nonalcoholic fatty liver disease. Gastroenterology 2009; 136: 1585-92.][Loomba R, Hwang S.J, O’Donnell C.J et al. Parental obesity and offspring serum alanine and aspartate aminotransferase levels: the Framingham heart study. Gastroenterology 2008; 134: 953-9.][Insulin Resistance. Ed. by David E. Moller.- Chichester: John Wiley&Sons. 1993: 425.][Чазова И.Е., Мычка В.Б. Метаболический синдром. М.: Медиа Медика, 2008.][Albu J.B, Curi M, Shur M et al. Systemic resistance to the antilipolytic effect of insulin in black and white women with visceral obesity. Am J Physiol 1999; 277 (3 Pt 1): 551-60.][Caprio S, Hyman L.D, Limb C et al. Central adiposity and its metabolic correlates in obese adolescent girls. Am J Physiol 1995; 269 (1 Pt 1): 118-26.][Saland J.M. Update on the metabolic syndrome in children. Curr Opin Pediatr 2007; 19: 183-91.][Болотова Н.В., Лазебникова С.В., Аверьянов А.П. Особенности формирования метаболического синдрома у детей и подростков. Педиатрия. 2007; 3: 35-9.][Захарова И.Н., Звенигородская Л.А., Яблочкова С.В. Метаболический синдром и неалкогольная жировая болезнь печени у детей. Эксперим. и клин. гастроэнтерология. 2011; 11: 44-8.][Thamer C, Machann J, Bachmann O et al. Intramyocellular lipids: anthropometric determinants and relationships with maximal aerobic capacity and insulin sensitivity. J Clin Endocrinol Metab 2003; 88: 1785-91.][Kelley D.E, Mc.Kolanis T.M, Hegazi R.A et al. Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance. Am J Physiol Endocrinol Metab 2003; 285: 906-16.][Weiss R, Taksali S.E, Dufour S et al. The «obese insulin - sensitive» adolescent: importance of adiponectin and lipid partitioning. J Clin Endocrinol Metab 2005; 90: 3731-7.][Сорвачева Т.Н., Петеркова В.А., Титова Л.Н. и др. Ожирение у подростков. Лечащий врач. 2006; 4: 50-4.][Лазебник Л.Б., Звенигородская Л.А. Метаболический синдром и органы пищеварения. М.: Анахарсис, 2009.][Davison K.K, Birch L.L. Obesigenic families: parents’ physical activity and dietary intake patterns predict girls’ risk of overweight. Int J Obes 2002; 26: 1186-93.][World Health Organisation. Defintion, diagnosis, and classification of diabetes mellitus and its complications: report of a WHO consultation, Part 1: diagnosis and classification of diabetes mellitus, 1999.][Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP). Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001; 285 (19): 2486-97.][Einhorn D, Reaven G.M, Cobin R.H et al. American College of Endocrinology position statement on the insulin resistance syndrome. Endocr Pract 2003; 9 (3): 237-52.][International Diabetes Federation consensus worldwide definition of the metabolic syndrome. 14 April, 2005.][Zimmet P, Alberti K.G.M.M, Kaufman F et al. The metabolic syndrome in children and adolescents - an IDF consensus report. Pediatric Diabetes 2007; 8: 299-306.][Harmonizing the metabolic syndrome: a joint interim statement of the IDF, NHLBI, AHA, WHF, IAS, IASO. Circulation 2009; 120 (16): 1640-5.][Goran M.I, Gower B.A, Treuth M, Nagy T.R. Prediction of intra - abdominal and subcutaneous abdominal adipose tissue in healthy prepubertal children. Int J Obes 1998; 22: 549-58.][Диагностика и лечение метаболического синдрома. Рекомендации ВНОК. Кардиоваскулярная терапия и профилактика. 2007; 2 (Прил. 2): 26.][Kurto lu S, Hatipo lu N, Mazхcхo lu M et al. Insulin Resistance in Obese Children and Adolescents: HOMA IR Cut Off Levels in the Prepubertal and Pubertal Periods. J Clin Res Pediatr Endocrinol 2010; 2 (3): 100-6.][Мищенкова Т.В., Звенигородская Л.А., Ткаченко Е.В. Роль эндоканнабиноидной системы в патогенезе морбидного ожирения. РМЖ. 2009; 11 (1): 12-7.][Звенигородская Л.А., Кучеренко Т.В., Ткаченко Е.В. и др. Типы пищевого поведения и гормоны пищевого поведения у больных с метаболическим синдромом. Эксперим. и клин. гастроэнтерология. 2007; 1: 24-7.][Захарова И.Н., Звенигородская Л.А., Яблочкова С.В. Метаболический синдром: взгляд педиатра. Эксперим. и клин. гастроэнтерология. 2010; 7: 84-91.][Troiano R.P, Briefel R.R, Carroll M.D, Bialostosky K. Energy and fat intakes of children and adolescents in the United States: data from the National Health and Nutrition Examination Surveys. Am J Clin Nutr 2000; 72 (Suppl.): 1343-53.][Dwyer J.T, Evans M, Stone E.J et al. Adolescents’ eating patterns influence their nutrient intakes. J Am Diet Assoc 2001; 101: 798-802.][American Dietetic Association. Evidence analysis library. Available at: www.adaevidencelibrary.com. Accessed July 12, 2007.][Малявская С.И., Дворяшина И.В., Терновская В.А. Метаболический инсулинрезистентный синдром: диагностика, клиническое значение, педиатрические аспекты: Монография. Архангельск: Северный государственный медицинский университет, 2004; с. 224.][Метаболический синдром. Под ред. Г.Е.Ройтберг. М.: Медпресс, 2007.][Tudor-Locke C, Ainsworth B.E, Popkin B.M. Active commuting to school: an overlooked source of childrens’ physical activity? Sports Med 2001; 31: 309-13.][Andersen R.E, Crespo C.J, Bartlett S.J et al. Relationship of physical activity and television watching with body weight and level of fatness among children: results from the Third National Health and Nutrition Examination Survey. JAMA 1998; 280: 1231-2.][Freemark M, Bursey D. Effects of Metformin on Body Mass Index and Glucose Tolerance in Obese Adolescents With Fasting Hyperinsulinemia and a Family History of Type 2 Diabetes. Pediatrics 2001; 107 (4): 55.][Knowler W.C, Barrett-Connor E, Fowler S.E et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346: 393-403.]