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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Consilium Medicum</journal-id><journal-title-group><journal-title xml:lang="en">Consilium Medicum</journal-title><trans-title-group xml:lang="ru"><trans-title>Consilium Medicum</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Consilium Medicum</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-1753</issn><issn publication-format="electronic">2542-2170</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">94184</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Klinicheskaya effektivnost' antagonistov mineralokortikoidnykh retseptorov v lechenii bol'nykh s khronicheskoy serdechnoy nedostatochnost'yu</article-title><trans-title-group xml:lang="ru"><trans-title>Клиническая эффективность антагонистов минералокортикоидных рецепторов в лечении больных с хронической сердечной недостаточностью</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Berns</surname><given-names>S. A</given-names></name><name xml:lang="ru"><surname>Бернс</surname><given-names>С. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zverev</surname><given-names>K. V</given-names></name><name xml:lang="ru"><surname>Зверев</surname><given-names>К. В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Myasnikov</surname><given-names>A. L</given-names></name><name xml:lang="ru"><surname>Мясников</surname><given-names>А. Л</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО МГМСУ им. А.И.Евдокимова Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ГУЗ Городская клиническая больница №71 Департамента здравоохранения г. Москвы</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2014-10-15" publication-format="electronic"><day>15</day><month>10</month><year>2014</year></pub-date><volume>16</volume><issue>10</issue><issue-title xml:lang="en">VOL 16, NO10 (2014)</issue-title><issue-title xml:lang="ru">ТОМ 16, №10 (2014)</issue-title><fpage>76</fpage><lpage>80</lpage><history><date date-type="received" iso-8601-date="2021-12-28"><day>28</day><month>12</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2014, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2014, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://consilium.orscience.ru/2075-1753/article/view/94184">https://consilium.orscience.ru/2075-1753/article/view/94184</self-uri><abstract xml:lang="ru"><p>В статье приведены данные относительно основных патогенетических механизмов влияния альдостерона в развитии сердечной недостаточности и действия антагонистов минералокортикоидных рецепторов. С позиции доказательной медицины обсуждена эффективность использования антагонистов минералокортикоидных рецепторов в целом и эплеренона, в частности, при лечении пациентов с ХСН.</p></abstract><kwd-group xml:lang="ru"><kwd>хроническая сердечная недостаточность</kwd><kwd>альдостерон</kwd><kwd>антагонисты минералокортикоидных рецепторов</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Белоусов Ю.Б., Упницкий А.А., Ханина Н.Ю. Перспективные направления в лечении сердечной недостаточности. Качественная клин. практика. 2006; 1: 2-9.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Zannad F, Mc Murray J.J.V, Krum H et al. Eplerenone in patients with systolic heart failure and mild symptoms. N Eng J Med 2011; 364: 11-21.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Pitt B, Zannad F, Remme W.J et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 1999; 341: 709-17.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Pitt B, Remme W, Zannad F et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003; 348: 1309-21.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Parthasarathy H.K, Menard J, White W et al. A double blind, randomized study comparing the antihypertensive effect of Eplerenone and spironolactone in patients with hypertension and evidence of primary aldosteronism. J Hypertens 2011; 29: 980-99.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Hunt S.A, Abraham W.T, Chin M.H et al. ACC/AHA guideline update for the diagnosis and management of chronic heart failure in the adult. www.acc.org/clinical/guidelines/failure/index</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Chronic heart failure: management of chronic heart failure in adults in primary and secondary care. London: National Institute for Clinical Excellence (NICE), 2010. (Clinical guidelines, CG108).</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Weinberger M.H, Roniker B, Krause S.L et al. Eplerenone, a selective aldosterone blocker, in mild - to - moderate hypertension. Am J Hypertens 2002; 15: 709-16.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Robert V, Ven Thiem N, Cheav S.L et al. Increased cardiac types I and III collagen mRNAs in aldosterone - salt hypertension. Hypertension 1994; 24: 30-6.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Silvestre J, Heymes C, Abdesalam O et al. Activation of cardiac aldosterone production in rat myocardial infarction: effect of angiotensin II receptor blockade and role in cardiac fibrosis. Circulation 1999; 99 (20): 2694-701.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Chai W, Garrelds I.M, De Vries R et al. Non genomic effects of aldosterone in the human heart: interaction with angiotensin II. Hypertension 2005; 46: 701-6.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Brilla C, Weber K. Reactive and reparative myocardial fibrosis in arterial hypertension in the rat. Cardiovasc Res 1992; 26: 671-7.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Багрий А.Э., Лукашенко Л.В., Яковенко В.Г. Селективный антагонист альдостерона Инспра (эплеренон) в лечении больных, перенесших инфаркт миокарда. Медицина неотложных состояний. 2007; 2 (9).</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Yamaji M, Tsutamoto T, Kawahara C et al. Effect of Eplerenone versus spironolactone on cortisol and hemoglobin A1c levels in patients with chronic heart failure. Am Heart J 2010; 160 (5): 915-21.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Gomez-Sanchez E.P, Ahmad N, Romero D.G et al. Origin of aldosterone in the rat heart. Endocrinology 2004; 145: 4796-802.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Schepkens H, Vanholder R, Billiouw J.M et al. Life - threatening hyperkalemia during combined therapy with angiotensin - converting enzyme inhibitors and Spironolactone: an analysis of 25 cases. Am J Med 2001; 110: 438-41.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Cruz C.S, Cruz A.A, Marcilio de Souza C.A. Hyperkalemia in congestive heart failure patients using ACE inhibitors and Spironolactone. Nephrol Dial Transplant 2003; 18: 1814-9.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Pitt B, Bakris G, Ruilope L et al. on Behalf of the EPHESUS Investigators. Serum potassium and clinical outcomes in the Eplerenone post acute myocardial infarction heart failure efficacy and survival study (EPHESUS). Circulation 2008; 118: 1643-50.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>De Gasparo M, Joss U, Ramjoue H.P et al. Three new epoxyspirolactone derivatives: characterization in vivo and in vitro. J Pharmacol Exp Ther 1987; 240 (2): 650-6.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Gardiner P, Schrode K, Quinlan D et al. Spironolactone metabolism: steady - state serum levels of the sulfur - containing metabolites. J Clin Pharmacol 1989; 29 (4): 342-7.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Brown N.J. Eplerenone: cardiovascular protection. Circulation 2003; 107 (19): 2512-8.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Sica D.A. Pharmacokinetics and pharmacodynamics of mineralocorticoid blocking agents and their effects on potassium homeostasis. Heart Fail Rev 2005; 10 (1): 23.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Swedberg K, Eneroth P, Kjekshus J et al. Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group. Circulation 1990; 82: 1730-6.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Tsai C.T, Chiang F.T, Tseng C.D et al. Increased expression of mineralocorticoid receptor in human atrial fibrillation and a cellular model of atrial fibrillation. J Am Coll Cardiol 2010; 55: 758-70.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Lendeckel U, Dobrev D, Goette A. Aldosterone - receptor antagonism as a potential therapeutic option for atrial fibrillation. Br J Pharmacol 2010; 159: 1581-3.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Agostoni P, Emdin M, Corra U, et al. Permanent atrial fibrillation affects exercise capacity in chronic heart failure patients. Eur Heart J 2008; 29: 2367-72.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Clark D.M, Plumb V.J, Epstein A.E et al. Hemodynamic effects of an irregular sequence of ventricular cycle lengths during atrial fibrillation. J Am Coll Cardiol 1997; 30: 1039-45.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Swedberg K, Zannad F, Mc Murray J.J.V et al. Eplerenone and Atrial Fibrillation in Mild Systolic Heart Failure. Results From the EMPHA- SIS-HF (Eplerenone in Mild Patients Hospitalization And Survival Study in Heart Failure). J Am Coll Cardiol 2012; 59 (18): 1598-603.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Poole-Wilson P.A, Swedberg K, Cleland J.G et al. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial. Lancet 2003; 362: 7-13.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Swedberg K, Komajda M, Bohm M et al. Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo - controlled study. Lancet 2010 376: 875-85.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Iqbal J, Fay R, Adlam D et al. Effect of eplerenone in percutaneous coronary intervention - treated post - myocardial infarction patients with left ventricular systolic dysfunction: a subanalysis of the EPH- ESUS trial. Eur J Heart Fail 2014; 16: 685-91.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Danjuma M.I, Mukherjee I, Makaronidis J et al. Converging Indications of Aldosterone Antagonists (Spironolactone and Eplerenone): A Narrative Review of Safety Profiles. Curr Hypertens Rep 2014; 16: 414.</mixed-citation></ref></ref-list></back></article>
