После регистрации препарата Праксбайнд® (идаруцизумаб*) рядом регулирующих органов в мире у врачей и пациентов в Европе, в том числе в странах Центральной и Восточной Европы, в антикоагулянтной терапии начался следующий этап.
Boehringer Ingelheim data on file.PRAXBINDR EMA Prescribing Information, 2015.Pollack C.V et al. Idarucizumab for Dabigatran Reversal. NEJM 2015; 373: 511-20.Glund S et al. Safety, tolerability, and efficacy of idarucizumab for the reversal of the anticoagulant effect of dabigatran in healthy male volunteers: a randomised, placebo - controlled, double - blind phase 1 trial. Lancet 2015; 386: 680-90.Glund S et al. Idarucizumab, a Specific Antidote for Dabigatran: Immediate, Complete and Sustained Reversal of Dabigatran Induced Anticoagulation in Elderly and Renally Impaired Subjects. Oral presentation on 8 December 2014 at The 56th American Society of Hematology Annual Meeting & Exposition, San Francisco, USA. Blood 2014; 124: Abstract 344.Glund S et al. A randomised study in healthy volunteers to investigate the safety, tolerability and pharmacokinetics of idarucizumab, a specific antidote to dabigatran. Thromb Haemost 2015; 113: 943-51.Schiele F et al. A specific antidote for dabigatran: functional and structural characterization. Blood 2013; 121: 3554-62.Pollack C.V et al. Design and rationale for RE-VERSE AD: A phase 3 study of idarucizumab, a specific reversal agent for dabigatran. Thromb Haemost 2015; 114: 198-205.