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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Consilium Medicum</journal-id><journal-title-group><journal-title xml:lang="en">Consilium Medicum</journal-title><trans-title-group xml:lang="ru"><trans-title>Consilium Medicum</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Consilium Medicum</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-1753</issn><issn publication-format="electronic">2542-2170</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">94388</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Key features of candesartan application in clinical practice</article-title><trans-title-group xml:lang="ru"><trans-title>Особенности применения кандесартана в клинической практике‌‌‌‌</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Evdokimova</surname><given-names>A. G</given-names></name><name xml:lang="ru"><surname>Евдокимова</surname><given-names>Анна Григорьевна</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, проф. каф. госпитальной терапии №2 ГБОУ ВПО МГМСУ им А.И.Евдокимова</p></bio><email>Aevdokimova@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lozhkina</surname><given-names>M. V</given-names></name><name xml:lang="ru"><surname>Ложкина</surname><given-names>Марина Витальевна</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, доц. каф. госпитальной терапии №2 ГБОУ ВПО МГМСУ им А.И.Евдокимова</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kovalenko</surname><given-names>E. V</given-names></name><name xml:lang="ru"><surname>Коваленко</surname><given-names>Елена Викторовна</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, доц. каф. госпитальной терапии №2 ГБОУ ВПО МГМСУ им А.И.Евдокимова</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">A.I.Evdokimov Moscow State Medical and Dental University of the Ministry of Health of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2016</year></pub-date><volume>18</volume><issue>1</issue><issue-title xml:lang="en">VOL 18, NO1 (2016)</issue-title><issue-title xml:lang="ru">ТОМ 18, №1 (2016)</issue-title><fpage>54</fpage><lpage>59</lpage><history><date date-type="received" iso-8601-date="2021-12-28"><day>28</day><month>12</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://consilium.orscience.ru/2075-1753/article/view/94388">https://consilium.orscience.ru/2075-1753/article/view/94388</self-uri><abstract xml:lang="en"><p>The article deals with the literature review concerning the candesartan cilexetil application in patients with arterial hypertension, chronic heart failure, chronic kidney disease, diabetes mellitus and other conditions. Particular attention is paid to the special aspects of the pharmacokinetics and pharmacodynamics of the drug, organoprotective properties, metabolic neutrality and safety application.</p></abstract><trans-abstract xml:lang="ru"><p>В статье представлен литературный обзор по применению кандесартана цилексетила у пациентов с артериальной гипертензией, хронической сердечной недостаточностью, хронической болезнью почек, сахарным диабетом и другими состояниями. Особое внимание уделено особенностям фармакокинетики и фармакодинамики препарата, органопротективным свойствам, его метаболической нейтральности и безопасности применения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>arterial hypertension</kwd><kwd>chronic heart failure</kwd><kwd>chronic kidney disease</kwd><kwd>diabetes mellitus</kwd><kwd>candesartan</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>артериальная гипертензия</kwd><kwd>хроническая сердечная недостаточность</kwd><kwd>хроническая болезнь почек</kwd><kwd>сахарный диабет</kwd><kwd>кандесартан</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Андрущишина Т.Б., Морозова Т.Е. Антагонисты рецепторов ангиотензина II при лечении кардиоваскулярных заболеваний // Consilium Medicum. 2009; 11 (5): 96-101.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Jonston C.I. 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