Consilium MedicumConsilium MedicumConsilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum94446ArticlesСтатьиResearch ArticleUltra-long-acting b2-agonists in the treatment of chronic obstructive pulmonary disease and bronchial asthmaB2-АГОНИСТЫ УЛЬТРАДЛИТЕЛЬНОГО ДЕЙСТВИЯ И ИХ РОЛЬ В ТЕРАПИИ ХРОНИЧЕСКОЙ ОБСТРУКТИВНОЙ БОЛЕЗНИ ЛЕГКИХ И БРОНХИАЛЬНОЙ АСТМЫKoutsenkoM. AКуценкоМаксим Андреевич

канд. мед. наук, доц. каф. госпитальной терапии ГБОУ ВПО РНИМУ им. Н.И.Пирогова, ст. науч. сотр. лаб. клин. фармакологии ФГБУ НИИ пульмонологии

mkmed@yandex.ruN.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian FederationГБОУ ВПО Российский национальный исследовательский медицинский университет им. Н.И.Пирогова МинздраваResearch Institute for PulmonologyФГБУ НИИ пульмонологии ФМБА России15032016183VOL 18, NO3 (2016)ТОМ 18, №3 (2016)475328122021Copyright ©; 2016, Consilium MedicumCopyright ©; 2016, ООО "Консилиум Медикум"2016Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://consilium.orscience.ru/2075-1753/article/view/94446

B2-Agonists are effective bronchodilators due primarily to their ability to relax airway smooth muscle. Short-acting b2- agonists provide rapid as-needed symptom relief and short-term prophylactic protection against bronchoconstriction induced by exercise or other stimuli. But it was very important to increase compliance of control regimen of bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD) medication. The 12-hours duration showed compliance increasing due to twice administration per day. Creating ultra-long-acting b2-agonists having a rapid onset of effect and acceptable safety profile with once-daily dose administration, is an important strategy to improve adherence and is a regimen preferred by most patients, which may also lead to enhancement of compliance, and may have advantages leading to improved overall clinical outcomes due to long-term and stability bronchodilating effect.

B2-Агонисты являются эффективными бронходилататорами за счет непосредственного воздействия на гладкую мускулатуру бронхов. b2-Агонисты короткого действия обеспечивают быстрый эффект для снятия симптомов и кратковременную профилактику бронхоспазма, индуцированного физической нагрузкой или другими триггерами. Важным шагом в повышении комплаентности базисной контролирующей терапии бронхиальной астмы (БА) и хронической обструктивной болезни легких (ХОБЛ) является снижение кратности использования препарата, что получило клиническое подтверждение при применении пролонгированных b2- агонистов, назначаемых 2 раза в день. Создание препаратов нового класса b2-агонистов ультрадлительного действия (24 ч) с быстрым началом действия и приемлемым профилем безопасности открывает новые возможности в лечении БА и ХОБЛ. Их включение в базисную терапию БА и ХОБЛ позволяет добиться лучшего контроля течения этих заболеваний как за счет повышения приверженности пациента назначенной терапии, так и стабильного и длительного бронходилатационного эффекта.

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