Consilium MedicumConsilium MedicumConsilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum94447ArticlesСтатьиResearch ArticleCircadian model of carbohydrate metabolism regulation in normalЦиркадная модель регуляции углеводного обмена в нормеKitcyshinV. PКицышинВиктор Петрович

д-р мед. наук, проф. 1 каф. (терапии усовершенствования врачей) ФГБВОУ ВО ВМА им. С.М.Кирова

SalukhovV. VСалуховВладимир Владимирович

д-р мед. наук, начальник 1 кафедры и клиники (терапии усовершенствования врачей) ФГБВОУ ВО ВМА им. С.М.Кирова

vlasaluk@yandex.ruDemidovaT. AДемидоваТатьяна Александровна

канд. мед. наук, ассистент 1 каф. (терапии усовершенствования врачей) ФГБВОУ ВО ВМА им. С.М.Кирова

SardinovR. TСардиновРуслан Тальгатович

канд. мед. наук, преп. 1 каф. (терапии усовершенствования врачей) ФГБВОУ ВО ВМА им. С.М.Кирова

S.M.Kirov Medical Military Academy of the Ministry of Education of the Russian FederationФГБВОУ ВО Военно-медицинская академия им. С.М.Кирова Минобразования России15042016184VOL 18, NO4 (2016)ТОМ 18, №4 (2016)384228122021Copyright ©; 2016, Consilium MedicumCopyright ©; 2016, ООО "Консилиум Медикум"2016Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://consilium.orscience.ru/2075-1753/article/view/94447

The variability of plasma glucose, which is identified as normal during the day, is not spontaneous. All of the known regulatory mechanisms of carbohydrate metabolism, without exaggeration, take part in its formation. These mechanisms are hierarchically structured. Their cyclic dynamics of functional activity, the close relationship between them based on the principle of operation of control systems with inverse connection create more or less obvious fluctuations of glucose. These fluctuations of glucose form typical stable patterns at certain time periods. The hypothalamus plays the most important role in this regulation. In particular, the suprachiasmatic nucleus forms the circadian rhythm of glucose dynamics of healthy people. The article is devoted to modern concepts of circadian functioning of the systems that regulate carbohydrate metabolism.

Выявляемая в норме на протяжении суток вариабельность глюкозы плазмы не является спонтанной. В ее формировании участвуют, без преувеличения, все известные регуляторные механизмы метаболизма углеводов. Эти механизмы иерархически структурированы, их циклическая динамика функциональной активности, тесные взаимосвязи между собой по принципу работы систем управления с обратной связью создают более или менее выраженные флуктуации глюкозы, образующие характерные устойчивые паттерны на определенных временных промежутках. Главенствующая роль в регуляции принадлежит гипоталамусу, в частности, - супрахиазматическому ядру, формирующему суточный ритм динамики глюкозы у здоровых людей. В статье представлены современные представления о циркадных особенностях функционирования систем регуляции углеводного обмена.

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