Consilium MedicumConsilium MedicumConsilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum94465ArticlesСтатьиResearch ArticleOn the role of neuroendocrine abnormalities in the pathogenesis of cognitive dysfunction in major depressive disorder (a literature review with authors’ comments)О роли нейроэндокринных нарушений в патогенезе когнитивной дисфункции при депрессивных состояниях (обзор литературы с комментариями)BekkerR. AБеккерРоман Александрович

исследователь в области психофармакотерапии, Университет им. Давида Бен-Гуриона в Негеве

BykovYu. VБыковЮрий Витальевичyubykov@gmail.comDavid Ben Gurion University in NegevУниверситет им. Давида Бен-Гуриона в НегевеStavropol State Medical University of the Ministry of Health of the Russian FederationГБОУ ВПО Ставропольский государственный медицинский университет Минздрава России15042016184VOL 18, NO4 (2016)ТОМ 18, №4 (2016)576128122021Copyright ©; 2016, Consilium MedicumCopyright ©; 2016, ООО "Консилиум Медикум"2016Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://consilium.orscience.ru/2075-1753/article/view/94465

Major depression correlates to several known neuroendocrine abnormalities (e.g. HPA axis dysregulation) and is often comorbid with endocrine disorders (e.g. diabetes). On the other hand, major depression is one of the leading causes of cognitive decline, and it is well-known fact that functional and social recovery correlates better to cognitive functioning than to general improvement in depressive symptoms. This article thoroughly reviews different correlations between endocrine functions and cognition, and the existing evidence base for hormonal/endocrine correction of cognitive dysfunctions commonly seen in depressions.

Депрессивные состояния часто сопровождаются теми или иными нейроэндокринными нарушениями или бывают коморбидны с эндокринными заболеваниями. В то же время депрессии часто сопровождаются развитием когнитивных нарушений, причем показано, что именно выраженность когнитивных нарушений в наибольшей степени определяет функциональные исходы и возможность социализации больных с депрессиями. В данной статье рассматриваются вопрос о влиянии нейроэндокринных нарушений на параметры когнитивного функционирования депрессивных больных и имеющаяся доказательная база для применения методов гормональной коррекции когнитивных нарушений при депрессивных состояниях, даются общего характера практические рекомендации по применению некоторых из них.

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