Consilium MedicumConsilium MedicumConsilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum94486ArticlesСтатьиResearch ArticleCognitive impairments in some deficit and dismetabolic statesКогнитивные нарушения при некоторых дисметаболических и дефицитарных состоянияхPizovaN. VПизоваНаталья Вячеславовна

д-р мед. наук, проф. каф. неврологии и медицинской генетики с курсом нейрохирургии ГБОУ ВПО ЯГМУ

pizova@yandeх.ruYaroslavl State Medical University of the Ministry of Health of the Russian FederationГБОУ ВПО Ярославский государственный медицинский университет Минздрава России15092015179VOL 17, NO9 (2015)ТОМ 17, №9 (2015)12112728122021Copyright ©; 2015, Consilium MedicumCopyright ©; 2015, ООО "Консилиум Медикум"2015Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://consilium.orscience.ru/2075-1753/article/view/94486

Cognitive impairments (CI) as one of the symptoms of the nervous system are often found in various states of deficit and dismetabolism. There is good evidence that CI is one of the main manifestations of developing encephalopathy in chronic liver disease, kidney disease, diabetes. At deficiency of cyanocobalamin (vitamin B12) and folic acid, hyperhomocysteinemia is observed in cognitive decline up to the development of dementia. The features of the CI in alcoholic lesion of the central nervous system are also discussed. The possible mechanisms of neuronal damage in the brain and dismetabolic of deficit states. The results of randomized clinical studies examining the efficacy of vitamins in patients with CI. Special attention is given to Berocca vitamins and minerals.

Когнитивные нарушения (КН) как один из симптомов поражения нервной системы нередко встречаются при различных дисметаболических и дефицитарных состояниях. Существуют убедительные данные о том, что при хронических заболеваниях печени, почек, сахарном диабете КН являются одним из основных проявлений развивающихся энцефалопатий. При дефиците цианокобаламина (витамина В12) и фолиевой кислоты, при гипергомоцистеинемии наблюдается снижение когнитивных функций вплоть до развития деменции. Представлены особенности КН при алкогольном поражении центральной нервной системы. Рассматриваются возможные механизмы повреждения нейронов головного мозга при дисметаболических и дефицитарных состояниях. Приводятся результаты рандомизированных клинических исследований, посвященных изучению эффективности применения витаминов у пациентов с КН. Отдельное внимание уделено витаминно-минеральному комплексу Берокка.

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