Consilium MedicumConsilium MedicumConsilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum9464710.26442/2075-1753_19.8.2.59-63ArticlesСтатьиReview ArticleDiabetes mellitus after liver transplantation: pathogenesis, risk factors, verification, impact on prognosisСахарный диабет после трансплантации печени: патогенез, факторы риска, верификация, влияние на прогнозKosmachevaE. DКосмачеваЕлена Дмитриевна

д-р мед. наук, доц., зав. каф. терапии №1 ФПК и ППС, зам. глав. врача по медицинской части

anna-babich1@yandex.ruBabichA. EБабичАнна Эдуардовна

аспирант каф. терапии №1 ФПК и ППС, врач-гастроэнтеролог

anna-babich1@yandex.ruProf. S.V.Ochapovsky Clinical Hospital №1 of the Ministry of Health of the Krasnodar RegionФГБОУ ВО КубГМУ, ГБУЗ «НИИ - ККБ№1 им. проф. С.В.Очаповского»Kuban State Medical University of the Ministry of Health of the Russian FederationКубГМУ, ГБУЗ «НИИ - ККБ№1 им. проф. С.В.Очаповского»Prof. S.V.Ochapovsky Clinical Hospital №1 of the Ministry of Health of the Krasnodar RegionKuban State Medical University of the Ministry of Health of the Russian Federation19082017198-2NO8-2 (2017)Том 19, №8-2 (2017)596328122021Copyright ©; 2017, Consilium MedicumCopyright ©; 2017, ООО "Консилиум Медикум"2017Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://consilium.orscience.ru/2075-1753/article/view/94647

Post-transplant diabetes mellitus (PTDM) is associated with increased morbidity and mortality after liver transplantation. The review presents literature data on current views on the pathogenesis, risk factors and verification of DM in the early and late posttransplant period. Particular attention is paid to the mechanisms of the diabetogenic action of cytostatics and immunosuppressants. The understanding of the mechanisms of occurrence, management of risk factors and early diagnosis of PTDM will contribute to prevention and the timely beginning of treatment.

Посттрансплантационный сахарный диабет (ПТСД) связан с повышенной заболеваемостью и смертностью после трансплантации печени. В обзоре представлены литературные данные о современных взглядах на патогенез, факторы риска и верификацию ПТСД в раннем и позднем посттрансплантационном периоде. Особое внимание уделяется механизмам диабетогенного действия цитостатиков и иммуносупрессантов. Понимание механизмов возникновения, управления факторами риска и раннее выявление ПТСД будут способствовать профилактике и своевременному началу лечения заболевания.

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