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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="data-paper" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Consilium Medicum</journal-id><journal-title-group><journal-title xml:lang="en">Consilium Medicum</journal-title><trans-title-group xml:lang="ru"><trans-title>Consilium Medicum</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Consilium Medicum</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-1753</issn><issn publication-format="electronic">2542-2170</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">94758</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Scientific Report</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Diagnosis and treatment of primary adrenal insufficiency in adult: a Russian Association of Endocrinology Clinical Practice Guideline (project)</article-title><trans-title-group xml:lang="ru"><trans-title>Клинические рекомендации Российской ассоциации эндокринологов по диагностике и лечению первичной надпочечниковой недостаточности у взрослых пациентов (проект)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Melnichenko</surname><given-names>G. A</given-names></name><name xml:lang="ru"><surname>Мельниченко</surname><given-names>Г. А</given-names></name></name-alternatives><bio xml:lang="ru"><p>акад. ран, д-р мед. наук, проф., дир. ФГБУ ЭНЦ</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Troshina</surname><given-names>E. A</given-names></name><name xml:lang="ru"><surname>Трошина</surname><given-names>Е. А</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, проф., зав. отд-нием терапевтической эндокринологии ФГБУ ЭНЦ</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Yukina</surname><given-names>M. Yu</given-names></name><name xml:lang="ru"><surname>Юкина</surname><given-names>М. Ю</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, ст. науч. сотр. отд. терапевтической эндокринологии, ФГБУ ЭНЦ</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Platonova</surname><given-names>N. M</given-names></name><name xml:lang="ru"><surname>Платонова</surname><given-names>Н. М</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, гл. науч. сотр. отд-ния терапевтической эндокринологии ФГБУ ЭНЦ</p></bio><email>doc-platonova@inbox.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Beltsevicha</surname><given-names>D. G</given-names></name><name xml:lang="ru"><surname>Бельцевич</surname><given-names>Д. Г</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, гл. науч. сотр. отд. хирургии ФГБУ ЭНЦ</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Endocrinology research center of the Ministry of Health of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБУ «Эндокринологический научный центр» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2017</year></pub-date><volume>19</volume><issue>4</issue><issue-title xml:lang="en">VOL 19, NO4 (2017)</issue-title><issue-title xml:lang="ru">ТОМ 19, №4 (2017)</issue-title><fpage>8</fpage><lpage>19</lpage><history><date date-type="received" iso-8601-date="2021-12-28"><day>28</day><month>12</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://consilium.orscience.ru/2075-1753/article/view/94758">https://consilium.orscience.ru/2075-1753/article/view/94758</self-uri><abstract xml:lang="en"><p>In the project of clinical recommendations Russian Association of Endocrinology focused on diagnosis and differential diagnosis of primary adrenal insufficiency with special reference to diagnostic steps, major pharmacological tests, instrumental studies. Strategies of management of patients with this pathology are described.</p></abstract><trans-abstract xml:lang="ru"><p>В статье представлен проект клинических рекомендаций Российской ассоциации эндокринологов по диагностике и лечению первичной надпочечниковой недостаточности, в котором приведен современный алгоритм обследования пациентов с первичной надпочечниковой недостаточностью, рассмотрены основные принципы лабораторной, инструментальной диагностики и патогенетические подходы к лечению.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Addison's disease</kwd><kwd>primary adrenal insufficiency</kwd><kwd>adrenal insufficiency</kwd><kwd>glucocorticoid replacement therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>болезнь Аддисона</kwd><kwd>первичная надпочечниковая недостаточность</kwd><kwd>надпочечниковая недостаточность</kwd><kwd>заместительная терапия глюкокортикоидами</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Hahner S, Allolio B. 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