Consilium MedicumConsilium MedicumConsilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum94761ArticlesСтатьиReview ArticleArterial hypertension and dementia: the potential of calcium antagonist nitrendipineАртериальная гипертония и деменция: потенциал антагониста кальция нитрендипинаKotovskayaYu. VКотовскаяЮ. В

д-р мед. наук, проф., зав. каф. кардиологии и персонифицированной медицины ФПК МР МИ ФГАОУ ВО РУДН, рук. лаб. сердечно-сосудистого старения Российского геронтологического научно-клинического центра ФГБОУ ВО «РНИМУ им. Н.И.Пирогова»

kotovskaya@bk.ruOstapenkoV. SОстапенкоВ. С

ассистент каф. болезней старения ФГБОУ ВО «РНИМУ им. Н.И.Пирогова», мл. науч. сотр. лаб. гериатрии Российского геронтологического научно-клинического центра

TkachevaO. NТкачеваО. Н

д-р мед. наук, проф., дир. Российского геронтологического научно-клинического центра, зав. каф. болезней старения ФДПО ФГБОУ ВО «РНИМУ им. Н.И.Пирогова»

People’s Friendship University of RussiaФГАОУ ВО «Российский университет дружбы народов»N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation«Российский геронтологический научно-клинический центр» ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И.Пирогова»15052017195VOL 19, NO5 (2017)ТОМ 19, №5 (2017)81328122021Copyright ©; 2017, Consilium MedicumCopyright ©; 2017, ООО "Консилиум Медикум"2017Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://consilium.orscience.ru/2075-1753/article/view/94761

The problem of dementia has a very important medical, social and economic importance in terms of the ageing of population. This review deals with the place of arterial hypertension as a risk factor for dementia and detection methods for dementia in the real clinical practice. The authors have analyzed the questionable association between blood pressure level and the development and progression of various types of dementia. The article showed the information about the efficacy of modern antihypertensive therapy for prevention of dementia with a focus on the potential of nitrendipine (calcium antagonist), which had showed the cerebroprotective potential in a number of investigational studies and large scale randomized placebo-controlled trial Syst-Eur.

Проблема деменции имеет очень важное медицинское, социальное и экономическое значение ввиду старения популяции. В представленном обзоре отражено место артериальной гипертонии как фактора риска деменции и методы выявления деменции в реальной клинической практике. Анализируется неоднозначная взаимосвязь уровня артериального давления с развитием и прогрессированием различных типов деменции. Приведены данные об эффективности современной антигипертензивной терапии для профилактики деменции с фокусом на потенциале антагониста кальция нитрендипина, показавшего свой церебропротективный потенциал в ряде экспериментальных исследований и крупномасштабном рандомизированном плацебо-контролируемом исследовании Syst-Eur.

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