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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Consilium Medicum</journal-id><journal-title-group><journal-title xml:lang="en">Consilium Medicum</journal-title><trans-title-group xml:lang="ru"><trans-title>Consilium Medicum</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Consilium Medicum</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-1753</issn><issn publication-format="electronic">2542-2170</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">94786</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The prolonged regime: contraceptive and non-contraceptive benefits</article-title><trans-title-group xml:lang="ru"><trans-title>Пролонгированный режим: контрацептивные и неконтрацептивные преимущества</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Karakhalis</surname><given-names>L. Yu</given-names></name><name xml:lang="ru"><surname>Карахалис</surname><given-names>Л. Ю</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, проф., проф. каф. акушерства, гинекологии и перинатологии ФПК и ППС ФГБОУ ВО КубГМУ</p></bio><email>lomela@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kuban State Medical University of the Ministry of Health of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2017</year></pub-date><volume>19</volume><issue>6</issue><issue-title xml:lang="en">VOL 19, NO6 (2017)</issue-title><issue-title xml:lang="ru">ТОМ 19, №6 (2017)</issue-title><fpage>54</fpage><lpage>56</lpage><history><date date-type="received" iso-8601-date="2021-12-28"><day>28</day><month>12</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://consilium.orscience.ru/2075-1753/article/view/94786">https://consilium.orscience.ru/2075-1753/article/view/94786</self-uri><abstract xml:lang="en"><p>The article concerns the prolonged use of contraception which has a lot of benefits compared to traditional use of oral contraception as it lowers the menstruation frequency, the risk of menstruation symptoms development, endometriosis and severe dysmenorrhea frequency by ceasing the endogenous estradiol production and providing highly effective, safe and reversal contraception. The article focuses on prolonged use of levonorgestrelcontaining hormonal contraceptive. Levonorgestrel increases the safety and tolerability of hormonal contraception.</p></abstract><trans-abstract xml:lang="ru"><p>В статье рассматриваются пролонгированные режимы контрацепции, имеющие неоспоримые преимущества перед традиционными формами оральной контрацепции: снижая число менструаций, сокращают риск распространенных менструальных симптомов, частоту эндометриоза или тяжелой дисменореи, предотвращая эндогенную продукцию эстрадиола и в то же время обеспечивая высокоэффективную, безопасную контрацепцию и быструю ее обратимость. В данной статье взгляд фокусируется на долгосрочном использовании левоноргестрелсодержащего комбинированного гормонального контрацептива. Свойства левоноргестрела повышают безопасность и переносимость гормональной контрацепции.</p></trans-abstract><kwd-group xml:lang="en"><kwd>hormonal contraception</kwd><kwd>prolonged regime</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>гормональная контрацепция</kwd><kwd>пролонгированный режим</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Schlaff W.D, Lynch A.M, Hughes H.D et al. Manipulation of the pill - free interval in oral contraceptive pill users: the effects on follicular suppression. Am J Obstet Gynecol 2004; 190: 943-51.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Sulak P.J, Scow R.D, Preece C et al. Hormone withdrawal symptoms in oral contraceptive users. Obstet Gynecol 2000; 95: 261-6.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Coffee A, Kuehl T.K, Willis S.A, Sulak P.J. Oral contraceptives and premenstrualsymptoms: comparisonof a 21/7 and extendedregimen. 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