Consilium MedicumConsilium MedicumConsilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum94788ArticlesСтатьиResearch ArticleGangrenous pyoderma: modern state of problemГангренозная пиодермия: современное состояние проблемыZhuchkovM. VЖучковМихаил Валерьевич

ассистент каф. сестринского дела, зам. глав. врача

misha.juchkov@gmail.comKopeykinA. AКопейкинАлександр Анатольевич

канд. мед. наук, ассистент каф. госпитальной хирургии, зам. глав. врача по мед. части

LovkovI. MЛовковИван Михайлович

врач-хирург

SinyakovA. VСиняковАлександр Валентинович

врач-хирург

RogachevV. IРогачевВячеслав Иванович

врач-хирург

ZhuchkovaU. VЖучковаУльяна Владимировна

врач-хирург

I.P.Pavlov Ryazan State Medical University of the Ministry of Health of the Russian FederationФГБОУ ВО РязГМУ, з ГБУ РО ОККВДRyazan State Regional Dermato-Venerological ClinicФГБОУ ВО РязГМУ, ГБУ РО ГКБСМПI.P.Pavlov Ryazan State Medical University of the Ministry of Health of the Russian FederationГБУ РО ГКБСМПCity Clinical Emergency HospitalГБУ РО ГКБСМПCity Clinical Emergency Hospital19072017197-2VOL 19, NO7-2 (2017)ТОМ 19, №7-2 (2017)232728122021Copyright ©; 2017, Consilium MedicumCopyright ©; 2017, ООО "Консилиум Медикум"2017Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://consilium.orscience.ru/2075-1753/article/view/94788

The article presents literature data devoted to modern problems of etiology, pathogenesis, diagnosis and treatment of gangrenous pyoderma. The authors also give their own observations and experience in the use of mycophenolate mofetil with gangrenous pyoderma.

В статье приводятся данные литературы, посвященные современному состоянию проблемы этиологии патогенеза, диагностики и лечения гангренозной пиодермии. Авторы также приводят собственные наблюдения и опыт использования микофенолата мофетила при гангренозной пиодермии.

гангренозная пиодермиянейтрофильный дерматозPowell F.C, Su W.P, Perry H.O. Pyoderma gangrenosum: classification and management. J Am Acad Dermatology 1996; 34: 395.Bennett M.L. et al. Pyoderma gangrenosum. A comparison of typical and atypical forms with an emphasis on time to remission. Case review of 86 patients from 2 institutions. Medicine (Baltimore) 2000; 79 (1): 37-46.Powell F.C. et al. Pyoderma gangrenosum: a review of 86 patients. Q J Med 1985; 55 (217): 173-86.Jain A et al. Bullous Pyoderma Gangrenosum Associated with Hairy Cell Leukemia and Its Complete Response to Cladribine Therapy. Indian J Hematol Blood Transfus 2017; 33 (2): 273-5.Vandemergel X. et al. Unusual association between auto-immune hepatitis and pyoderma gangrenosum. A case report. Rev Med Brux 2017; 38 (2): 95-8.Okamura K.et al. A case of primarily facial pyoderma gangrenosum associated with Takayasu arteritis. JAAD Case Rep 2017; 3 (2): 124-6.Gobert J, Mercuzot A, Sergent F. A new pyoderma gangrenosum case revealing breast cancer. Gynecol Obstet Fertil Senol 2017; 45 (1): 54-5.Maranda E.L. et al. A case of eosinophilic fasciitis associated with pyoderma gangrenosum. J Eur Acad Dermatol Venereol 2017; 31 (2): e101-e102.Lane C.G. Pyoderma gangrenosum. Arch Derm Syphilol 1947; 55 (5): 714.T helper 1-related molecules as well as IL-15 are hyperexpressed in the skin lesions of patients with pyoderma gangrenosum. Clin Exp Immunol 2017; 189 (3): 383-91.Antiga E, Braswell S.F, Kostopoulos T.C, Ortega-Loayza A.G. Pathophysiology of pyoderma gangrenosum (PG): an updated review. J Am Acad Dermatol 2015; 73 (4): 691-8.Karimi K. et al. Acute Cutaneous Necrosis: A Guide to Early Diagnosis and Treatment. J Cutan Med Surg 2017; 21 (5): 425.Gameiro A. et al. Pyoderma gangrenosum: challenges and solutions. Clin Cosmet Investig Dermatol 2015; 8: 285-93.Marzano A.V. et al. Pyoderma gangrenosum with severe cutaneous and oral involvement. Eur J Dermatol 2013; 23 (2): 257-8.Chaby G. et al. Topical silver sulfadiazine-induced acute renal failure. Ann Dermatol Venereol 2005; 132 (11 Pt. 1): 891-3.Rodenbeck D.L, Kennon A.W, Davis L.S. Peristomal pyoderma gangrenosum (PG): A simple hydrocolloid dressing technique to promote wound healing. J Am Acad Dermatol 2015; 73 (3): 107-8.Smith K.C, Su W.P, Leiferman K.M. Cromolyn sodium in 2% aqueous solution under an occlusive hydrocolloid dressing may be effective adjunctive treatment in management of pyoderma gangrenosum. J Am Acad Dermatol 1987; 17 (3): 509-11.Винник Ю.С., Маркелова Н.М., Тюрюмин В.С. Современные методы лечения гнойных ран. Сиб. мед. образование. 2013; 1: 18-24.Wirtzfeld N. et al. Pathergic postsurgical-induced Pyoderma gangrenosum. Rev Med Liege 2017; 72 (5): 227-32.Barańska-Rybak W. et al. A retrospective study of 12 cases of pyoderma gangrenosum: why we should avoid surgical intervention and what therapy to apply. Am Surg 2011; 77 (12): 1644-9.Goshtasby P.H, Chami R.G, Johnson R.M. A novel approach to the management of pyoderma gangrenosum complicating reduction mammoplasty. Aesthet Surg J 2010; 30 (2): 186-93.Patel D.K, Locke M, Jarrett P. Pyoderma gangrenosum with pathergy: A potentially significant complication following breast reconstruction. J Plast Reconstr Aesthet Surg 2017; 70 (7): 884-92.Ruebhausen M.R et al. Postsurgical Pyoderma Gangrenosum Following Carpal Tunnel Release: A Rare Disease Following a Common Surgery. Eplasty 2017; 17: 10.Kechichian E. et al. Pediatric pyoderma gangrenosum: a systematic review and update. Int J Dermatol 2017; 56 (5): 486-95. DOI: 10.1111/ijd.13584Larsen C.G, Thyssen J.P. Pustular penile pyoderma gangrenosum successfully treated with topical tacrolimus ointment. Acta Derm Venereol 2012; 92 (1): 104-5.Thomas K.S. et al. Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: A prospective cohort study. J Am Acad Dermatol 2016; 75 (5): 940-9.Van Der Hoeden R. et al. Pyoderma gangrenosum complicating ulcerative colitis; cure during cortisone therapy. Acta Gastroenterol Belg 1955; 18 (3): 246-57.Pompeo M.Q. Pyoderma Gangrenosum: Recognition and Management. Wounds 2016; 28 (1): 7-13.Brown R.E, Lay L, Graham D. Bilateral pyoderma gangrenosum of the hand: treatment with dapsone. J Hand Surg Br 1993; 18 (1): 119-21.Kaplan B. et al. Treatment of pyoderma gangrenosum with clofazimine. Int J Dermatol 1992; 31 (8): 591-3.Matis W.L. et al. Treatment of pyoderma gangrenosum with cyclosporine. Arch Dermatol 1992; 128 (8): 1060-4.Teitel A.D. Treatment of pyoderma gangrenosum with methotrexate. Cutis 1996; 57 (5): 326-8.Hohenleutner U et al. Mycophenolate mofetil and cyclosporin treatment for recalcitrant pyoderma gangrenosum. Lancet 1997; 350 (9093): 1748.Nousari H.C et al. The effectiveness of mycophenolate mofetil in refractory pyoderma gangrenosum. Arch Dermatol 1998; 134 (12): 1509-11.Al Ghazal P, Dissemond J. Therapy of pyoderma gangrenosum in Germany: results of a survey among wound experts. J Dtsch Dermatol Ges 2015; 13 (4): 317-24.Bobbitt S.A. et al. Treatment of refractory pyoderma gangrenosum with infliximab in a 17-month-old boy. Dermatol Online J 2016; 22 (4).Lankarani K.B. Infliximab for treatment of pyoderma gangrenosum. Neth J Med 2015; 73 (7): 357.