<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Consilium Medicum</journal-id><journal-title-group><journal-title xml:lang="en">Consilium Medicum</journal-title><trans-title-group xml:lang="ru"><trans-title>Consilium Medicum</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Consilium Medicum</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-1753</issn><issn publication-format="electronic">2542-2170</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">94851</article-id><article-id pub-id-type="doi">10.26442/2075-1753_19.10.8-12</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Polypill in the prevention of cardiovascular diseases: evidence base, limitations and prospects (based on the report of the European Society for Hypertension)</article-title><trans-title-group xml:lang="ru"><trans-title>Политаблетка в профилактике сердечно-сосудистых заболеваний: доказательная база, ограничения и перспективы (по материалам доклада Европейского общества по артериальной гипертензии)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Morozova</surname><given-names>T. E</given-names></name><name xml:lang="ru"><surname>Морозова</surname><given-names>Татьяна Евгеньевна</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, проф., зав. каф. клин. фармакологии и фармакотерапии ИПО</p></bio><email>temorozova@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Yudina</surname><given-names>I. Yu</given-names></name><name xml:lang="ru"><surname>Юдина</surname><given-names>Ирина Юрьевна</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, доц. каф. клин. фармакологии и фармакотерапии ИПО</p></bio><email>klinfarma@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Karnoukh</surname><given-names>K. I</given-names></name><name xml:lang="ru"><surname>Карноух</surname><given-names>Константин Игоревич</given-names></name></name-alternatives><bio xml:lang="ru"><p>ординатор каф. клин. фармакологии и фармакотерапии ИПО</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shatskiy</surname><given-names>D. A</given-names></name><name xml:lang="ru"><surname>Шацкий</surname><given-names>Дмитрий Андреевич</given-names></name></name-alternatives><bio xml:lang="ru"><p>ординатор каф. клин. фармакологии и фармакотерапии ИПО</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I. M.Sechenov First Moscow Medical University of the Ministry of Health of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М.Сеченова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-10-15" publication-format="electronic"><day>15</day><month>10</month><year>2017</year></pub-date><volume>19</volume><issue>10</issue><issue-title xml:lang="en">VOL 19, NO10 (2017)</issue-title><issue-title xml:lang="ru">ТОМ 19, №10 (2017)</issue-title><fpage>8</fpage><lpage>12</lpage><history><date date-type="received" iso-8601-date="2021-12-28"><day>28</day><month>12</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://consilium.orscience.ru/2075-1753/article/view/94851">https://consilium.orscience.ru/2075-1753/article/view/94851</self-uri><abstract xml:lang="en"><p>The article discusses the evidence base, limitations and prospects for the use of combined multicomponent drugs in the prevention of cardiovascular diseases. Complex of antihypertensive, lipid-lowering, hypoglycemic and antiplatelet therapy significantly reduces the risk of cardiovascular complications and fatal events. However, in real clinical practice, a full implementation of all these approaches is not always carried out, which reduces the effectiveness of preventing cardiovascular diseases.</p></abstract><trans-abstract xml:lang="ru"><p>В статье обсуждаются доказательная база, ограничения и перспективы использования комбинированных многокомпонентных препаратов в профилактике сердечно-сосудистых заболеваний. Комплексная антигипертензивная, липидснижающая, сахароснижающая и антиагрегантная терапия существенно снижает риск сердечно-сосудистых осложнений и фатальных событий. Однако в реальной клинической практике полноценная реализация всех этих подходов не всегда проводится, что снижает эффективность профилактики сердечно-сосудистых заболеваний.</p></trans-abstract><kwd-group xml:lang="en"><kwd>poly-drug</kwd><kwd>polypill</kwd><kwd>adherence</kwd><kwd>risk factors</kwd><kwd>arterial hypertension</kwd><kwd>prevention</kwd><kwd>combined therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>политаблетка</kwd><kwd>полипилюля</kwd><kwd>приверженность</kwd><kwd>факторы риска</kwd><kwd>артериальная гипертензия</kwd><kwd>профилактика</kwd><kwd>комбинированная терапия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>World Health Organization. Secondary prevention of noncommunicable disease in low and middle income countries through communitybased and health service interventions. WHO - Wellcome Trust Meeting report 1-3. Geneva: World Health Organization; 2002.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Yusuf S. Two decades of progress in preventing vascular disease. Lancet 2002; 360: 2-3.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Wald N.J, Law M.R. A strategy to reduce cardiovascular disease by more than 80%. BMJ 2003;326:1419.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Chapman R.H., Benner J.S, Petrilla A.A. et al. Predictors of adherence with antihypertensive and lipid-lowering therapy. Arch Intern Med 2005; 165: 1147-52.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Corrao G, Conti V, Merlino L et al. Results of a retrospective database analysis of adherence to statin therapy and risk of nonfatal ischemic heart disease in daily clinical practice in Italy. Clin Ther 2010; 32: 300-10.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>DiMatteo M.R. Variations in patients’ adherence to medical recommendations: a quantitative review of 50 years of research. Med Care 2004; 42: 200-9.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Wang T.D, Chen Y.H, Huang C.H. et al. Bidirectional adherence changes and associated factors in patients switched from free combinations to equivalent single-pill combinations of antihypertensive drugs. Hypertension 2014; 63: 958-67.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Gerbino P.P, Shoheiber O. Adherence patterns among patients treated with fixed-dose combination versus separate antihypertensive agents. Am J Health Syst Pharm 2007; 64: 1279-83.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Brambilla G, Bombelli M, Seravalle G et al. Prevalence and clinical characteristics of patients with true resistant hypertension in central and Eastern Europe: data from the BPCA- RE study. J Hypertens 2013; 31: 2018-24.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Kotseva K, Wood D, De Backer G et al, EUROASPIRE Study Group. EUROASPIRE III: a survey on the lifestyle, risk factors and use of cardioprotective drug therapies in coronary patients from 22 European countries. Eur J Cardiovasc Prev Rehabil 2009; 16: 121-37.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Volpe M, Tocci G, Trimarco B et al. Blood pressure control in Italy: results of recent surveys on hypertension. J Hypertens 2007; 25: 1491-8.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Mancia G, Fagard R, Narkiewicz K et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2013; 31: 1281-357.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Zanchetti A. Bottom blood pressure or bottom cardiovascular risk? How far can cardiovascular risk be reduced? J Hypertens 2009; 27: 1509-20.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Ho P.M, Bryson C.L, Rumsfeld J.S. Medication adherence: its importance in cardiovascular outcomes. Circulation 2009; 119: 3028-35.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Hughes D, McGuire A. The direct costs to the NHS of discontinuing and switching prescriptions for hypertension. J Hum Hypertens 1998; 12: 533-7.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>McCombs J.S, Nichol M.B, Newman C.M, Sclar D.A. The costs of interrupting antihypertensive drug therapy in a Medicaid population. Med Care 1994; 32: 214-26.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Corrao G, Parodi A, Nicotra F et al. Better compliance to antihypertensive medications reduces cardiovascular risk. J Hypertens 2011; 29: 610-8.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Corrao G, Rea F, Ghirardi A et al. Adherence with antihypertensive drug therapy and the risk of heart failure in clinical practice. Hypertension 2015; 66: 742-9.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Corrao G, Ibrahim B, Nicotra F et al. Long-term use of statins reduces the risk of hospitalization for dementia. Atherosclerosis 2013; 230: 171-6.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Hameed M.A, Dasgupta I, Gill P. Poor adherence to antihypertensive drugs. BMJ 2016; 354: i3268.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Mancia G, Zambon A, Soranna D et al. Factors involved in the discontinuation of antihypertensive drug therapy: an analysis from real life data. J Hypertens 2014; 32: 1708-15.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Holmes H.M, Luo R, Hanlon J.T et al. Ethnic disparities in adherence to antihypertensive medications of Medicare part D beneficiaries. J Am Geriatr Soc 2012; 60: 1298-303.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Law M.R, Wald N.J, Morris J.K, Jordan R.E. Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials. BMJ 2003; 326: 1427.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Sinnott S.J, Buckley C, O’Riordan D et al. The effect of copayments for prescriptions on adherence to prescription medicines in publicly insured populations; a systematic review and meta-analysis. PLoS One 2013; 8:e64914.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Gupta A.K, Arshad S, Poulter N.R. Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents: a metaanalysis. Hypertension 2010; 55: 399-407.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Zanchetti A, Thomopoulos C, Parati G. Randomized controlled trials of blood pressure lowering in hypertension: a critical reappraisal. Circ Res 2015; 116: 1058-73.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Yusuf S, Pais P, Sigamani A et al. Comparison of risk actor reduction and tolerability of a full-dose polypill (with potassium) versus low-dose polypill (Polycap) in individuals at high risk of cardiovascular diseases the Second Indian Polycap Study (TIPS-2) investigators. Circ Cardiovasc Qual Outcomes 2012; 5: 463-71.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Thom S, Poulter N, Field J et al. Effects of a fixed-dose combination strategy on adherence and risk factors in patients with or at high risk of CVD: the UMPIRE randomized clinical trial. JAMA 2013; 310: 918-29.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Selak V, Elley C.R, Bullen C et al. Effect of fixed dose combination treatment on adherence and risk factor control among patients at high risk of cardiovascular disease: randomized controlled trial in primary care. BMJ 2014; 348: g3318.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Patel A, Cass A, Peiris D et al. A pragmatic randomized trial of a polypill-based strategy to improve use of indicated preventive treatments in people at high cardiovascular disease risk. Eur J Prev Cardiol 2015; 22: 920-30.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Polypill strategy to improve adherence: results from the FOCUS project. J Am Coll Cardiol 2014; 64: 2071-82.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Tamargo J, Castellano J.M, Fuster V. The Fuster-CNIC-Ferrer cardiovascular polypill: a polypill for secondary cardiovascular prevention. Int J Cardiol 2015; 201 (Suppl 1): S15-S22.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Kolte D, Aronow W.S, Banach M. Polypills for the prevention of cardiovascular diseases. Expert Opin Investig Drugs 2016; 22: 1-10.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Guglietta A, Guerrero M. Issues to consider in the pharmaceutical development of a cardiovascular polypill. Nat Clin Pract Cardiovasc Med 2009; 6: 112-9.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Prevention of Cardiovascular Disease in Middle-aged and Elderly Iranians Using a Single PolyPill (PolyIran). Available at: http://clinicaltrials. gov/ct2/show/NCT01271985.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Thomopoulos C, Parati G, Zanchetti A. Effects of blood pressure lowering on outcome incidence in hypertension: 3. Effects in patients at different levels of cardiovascular risk - overview and meta-analyses of randomized trials. J Hypertens 2014; 32: 23052314.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Huffman M.D, Xavier D, Perel P. Uses of polypills for cardiovascular disease and evidence to date. Lancet 2017; 389: 1055-65.</mixed-citation></ref></ref-list></back></article>
