Consilium MedicumConsilium MedicumConsilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum9487610.26442/2075-1753_19.9.49-54ArticlesСтатьиResearch ArticleMelatonin and its possibilities in the therapy of chronic painМелатонин и его возможности в терапии хронической болиKurganovaYu. MКургановаЮлия Михайловна

канд. мед. наук, аспирант каф. нервных болезней

j.kurganova@yandex.ruDanilovA. BДаниловАндрей Борисович

д-р мед. наук, проф. каф. нервных болезней

I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian FederationФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М.Сеченова» Минздрава России15092017199VOL 19, NO9 (2017)ТОМ 19, №9 (2017)495428122021Copyright ©; 2017, Consilium MedicumCopyright ©; 2017, ООО "Консилиум Медикум"2017Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://consilium.orscience.ru/2075-1753/article/view/94876

The aim of the study was to examine the analgesic effect of melatonin in chronic nonspecific pain in the back. Materials and methods. The study involved 178 patients aged 40 to 65 years with chronic nonspecific pain in the lower back with a duration of pain more than 3 months and an intensity of more than 3 points on a visual analog scale. Patients were divided into 6 groups, which comprised 3 pairs of comparison - the main group and the comparison group. In the 1 st pair, the patients of the main group (n=31) and the comparison group (n = 29) received a combined preparation of glucosamine hydrochloride 500 mg and chondroitin sulfate 500 mg 1 tablet 2 times a day for 1 month, then 1 tablet per day for 2 months, in addition, patients of the main group received melatonin (Melaxen) 3 mg for 30-40 minutes before bedtime. In the 2nd pair, the comparison groups (n=30) took a combined preparation of glucosamine hydrochloride 500 mg and chondroitin sulfate 500 mg 1 tablet 2 times a day and diclofenac 25 mg 2-3 times a day, patients from the main group (n=30) additionally received melatonin (Melaxen) according to the same scheme used in the first pair of comparison. In the third pair, patients of the main group (n=29) received diclofenac 25 mg 3 times a day and melatonin (Melaxen) as described above, patients from the comparison group (n=29) received only diclofenac. The duration of follow-up in the first pair was 3 months, in the 2 nd and 3 rd couples - 1 month. Results and conclusion. Data obtained showed statistically significantly greater reduction in pain intensity during movement and at rest in all major groups than in comparison groups. It is concluded that the addition of melatonin to the standard treatment of back pain increases its effectiveness.

Цель исследования - изучение обезболивающего действия мелатонина при хронической неспецифической боли в спине. Материал и методы. В исследовании приняли участие 178 пациентов в возрасте от 40 до 65 лет с хронической неспецифической болью в нижней части спины при длительности боли более 3 мес и интенсивности более 3 баллов по визуальной аналоговой шкале. Пациенты были разделены на 6 групп, которые составили 3 пары сравнения - основная группа и группа сравнения. В 1-й паре больные основной группы (n=31) и группы сравнения (n=29) получали комбинированный препарат глюкозамина гидрохлорида 500 мг и хондроитина сульфата 500 мг по 1 таблетке 2 раза в день на протяжении 1 мес, затем по 1 таблетке в течение 2 мес, дополнительно пациенты основной группы получали мелатонин (Мелаксен) 3 мг за 30-40 мин до сна. Во 2-й паре больные группы сравнения (n=30) принимали комбинированный препарат глюкозамина гидрохлорида 500 мг и хондроитина сульфата 500 мг по 1 таблетке 2 раза в день и диклофенак в дозе 25 мг 2-3 раза в день, пациенты из основной группы (n=30) дополнительно принимали мелатонин (Мелаксен) по аналогичной применяемой в 1-й паре сравнения схеме. В 3-й паре больные основной группы (n=29) получали диклофенак в дозе 25 мг 3 раза в день и мелатонин (Мелаксен) по описанной выше схеме, пациенты из группы сравнения (n=29) получали только диклофенак. Длительность наблюдения в 1-й паре составила 3 мес, во 2 и 3-й парах - 1 мес. Результаты и заключение. Были получены данные, демонстрирующие статистически достоверно более значительное снижение интенсивности боли при движении и в покое во всех основных группах, чем в группах сравнения. Сделан вывод, что добавление мелатонина к стандартной схеме лечения боли в спине повышает ее эффективность.

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