Consilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum94881Review ArticleComparative efficacy of different antihistamines II generation in adult patients with seasonal allergic rhinitisBodnyaO. Sos.bodnya@yandex.ruNenashevaN. M-AndrenovaG. V-SinyavkinD. O-BodnyaYa. V-KubanovaE. T-Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian FederationCity Clinical Hospital of the Department of Health of Moscow №52M.V.Lomonosov Moscow State University1503201719310110828122021Copyright © 2017, Consilium Medicum2017Allergic rhinitis plays leading role in the structure of allergic diseases. The second generation of antihistamines are frequently used to cure allergic rhinitis, including seasonal manifestations. In the following paper the comparative results of open, randomize clinical studies of efficiency, safety and influenceon quality of life of patients, suffered from seasonal allergic rhinitis, treated by original AGP II ebastine and generic AGP II cetirizine and loratadine are discussed. Its efficiency and safety providing control on mild nasal and non-nasal symptoms of seasonal rhinitis in mature patients have been demonstrated. It is noticed that the rate of onset of effect and its expression in relation to nasaland non-nasal symptoms were much efficient in patients, obtained ebastine 20 mg comparing with cetirizine 10 mg and loratadine 10 mg.Seasonal allergic rhinitisebastine (Kestine®)the second generation of antihistaminesсезонный аллергический ринитэбастин (Кестин®)антигистаминные препараты II поколения[Дробик O.C., Насунова А.Ю. Аллергический ринит - взгляд аллерголога. Вестн. отоларингологии. 2014; 2: 82-5.][Van Cauwenberge P, Bachert C, Bousquet J et al. Consensus statement on the treatment of allergic rhinitis. EAACI. Positionpaper. Allergy 2000; 55: 116134.][Allergic rhinitis and its impact on asthma (ARIA). WHO initiative, 2001-2010.][Ненашева Н.М., Ильина Н.И., Бердникова Н.Г. Эффективность и безопасность препарата Момат Рино (мометазонафуроат в виде спрея назального дозированного) у взрослых пациентов с круглогодичным аллергическим ринитом: результаты рандомизированного открытого мультицентрового клинического исследования // Consilium Medicum. 2016; 18 (11): 102-9.][Бодня О.С., Ненашева Н.М. В помощь практикующему врачу: ведение пациентов с аллергическим ринитом на амбулаторном этапе. Астма и аллергия. 2015; 4: 28-34.][Canonica G.W, Bousquet J, Mullol J et al. A survey of the burden of allergic rhinitis in Europe. Allergy 2007; 62 (Suppl. 85): 17-25.][Fortea J, Mora S, Artes M. Ebasstine fast - dissolving tablets versus regular tablets: Acceptability and preference in patients with allergic rhinitis. Expert Rev Clin Pharmacol. 2008; 1: 381-9.][Ratner P, Falques M, Chuecos F et al. Meta - Analysis of the Efficacy of Ebastine 20 mg Compared to Loratadine 10 mg and Placebo in the Symptomatic Treatment of Seasonal Allergic Rhinitis. Int Arch Allergy Immunol 2005; 138: 312-8.][Campbell A, Michel F.B, Bremard-Oury C et al. Overview of allergic mechanisms. Ebastine has more than an antihistamine effect. Drugs 1996; 52 (Suppl. 1): 15-9.][Horiguchi T, Tachikawa S, Kasahara J et al. Effect of Ebastine on Serum Eosinophil Cationic Protein Levels in Patients with Bronchial Asthma. Clin Drug Invest 1999; 17 (6): 435-40.]