Consilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum9493510.26442/2075-1753_19.10.96-104Review ArticleOmega-3 fatty acids in cardiology practiceVasilevA. P-StreltsovaN. Nsss@cardio.tmn.ruTyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Science1510201719109610428122021Copyright © 2017, Consilium Medicum2017Omega-3 essential fatty acids have major roles in all sorts of bodily processes. Numerous observational studies demonstrate that increase consumption of fishmeal as a replacement of the nutrient deficiency caused by modern dietary habits tends to reduce risk of cardiovascular diseases. Taking omega 3 fatty acids capsules during therapy may significantly reduce sudden cardiac death in patients with a history of myocardial infarction; improve survival in congestive heart failure patients; possess antiarrhythmic effect. The main purpose of this review is to draw attention of doctors to this important therapeutic area and to remind that the use of omega-3 fatty acids is appropriate and effective for primary and secondary prevention of cardiovascular diseases, as well as to emphasize the necessity of its wide-ranging use in patients with myocardial infarction, heart failure, and adding in the combination therapy of arrhythmia.omega-3 fatty acidscardiovascular diseasesомега-3-жирные кислотысердечно-сосудистые заболевания[Albert C.M, Campos H, Stampler M.J et al. Blood PUFAs and the risk of sudden death. N Engl J Med 2002; 346: 1113-8.][Mozaffarian D, Lemaitre R.N, Kuller L.H. et al. Cardiac Benefits of Fish Consumption May Depend onthe Type of Fish Meal Consumed. Circulation 2003; 107: 1372-7.][Chrysohoou C, Panagiotakos D.B, Pitsavos C. Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The ATTICA Study. J Am Coll Cardiol 2004; 44: 152-8.][Iso H, Rexrode K.M, Stampfer M.J. Intake of fish and omega-3 fatty acids and risk of stroke in women. J Am Med Assoc 2000; 285: 304-12.][Shekele R.B, Missell L.V, Paul O et al. Fish consumption and mortality from coronary heart disease. N Engl J Med 1985; 313: 820.][Hu F.B, Bronner L, Willett W.C. et al. Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA 2002; 287: 1815-21.][Daviglus M.L Stamler J, Orencia A.J et al. Fish consumption and the 30 year risk of fatal myocardial infarction. N Engl J Med 1997; 336: 1046-53.][Kromhout D, Bosschieter E.B, Coulander C. The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N Engl J Med 1990; 7: 173-6.][Kris-Etherton P.M. Fish consumption, fish oil, omega-3 fatty acids and cardiovasculardi- sease. Circulation 2002; 106: 2747-57.][Siscovick D.S, Raghunathan T.E. et al. Dietary intake and cell membrane levels of long chain o3 - polyunsaturated fatty acids and the risk of primary cardiac arrest. J Am Med Assoc 1995;274: 1363-7.][Keli S.O. et al. Fish consumption and risk of stroke: the Zutphen Study. Stroke 1994; 25: 328-32.][Caro J, Klittich W, McGuire A. The West of Scotland coronary prevention study: economic benefit analysis of primary prevention with pravastatin. BMJ 1997; 315: 1577-82.][Myerburg R.J, Spooner P.M. Opportunities for sudden death prevention: Directions for new clinical and basic research. Cardiovasc Res 2001; 50: 177-85.][Priori G, Aliot E, Blomstrom-Lundqvist C et al. Task Force on Sudden Cardiac Death of the European Society of Cardiology. Eur Heart J 2001; 22: 1374-450.][Burr M.L, Fehily A.M, Gilbert J..F et al. Effects ofchanges in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet 1989; 2 (8666): 757-61.][Erkkila A.T, Mattman N.R, Herrington D.M, Lichtenstein A.H. Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD. J Lipid Res 2006; 47: 2814-9.][Результаты исследования OCEAN (Omacor Carotid Endarterectomy Intervention Trial). XIV Международный симпозиум по атеросклерозу. Рим, 18-22 июня 2006][Eritsland J, Arnesen H, Gronseth Ket al. Effect of dietary supplementation with n-3 fatty acids on coronary artery bypass graft patency. Am J Cardiol 1996; 77: 31-6.][Hooper L, Thompson R.L, Harrison R.A. et al. Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review. Br Med J 2006; 332: 752-60.][Harris W.S, Ginsberg H.N, Arunakul N et al. Safety and efficacy of Omacor in severe hypertriglyceridemia. J Cardiovasc Risk 1997; 4 (5/6): 385-91.][Dietary supplementation with o-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 1999; 354: 447-55.][GISSI-HF investigators. Effekt of n-3 polyunsaturated acids in patients with chronic heart failure (the GISSI-HF trial): a randomized, double-blind, placebo-controlled trial. Lancet 2008;372:1223.][Nodari S, Triggiani M, Campia U et al. Effects of n-3 polyunsaturated fatty acids on left ventricular function and functional capacity in patients with dilated cardiomyopathy. J Am Coll Cardiol 2011; 57: 870-9.][ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death. Eur Heart J 2006; 27: 2099-140.][Leaf A. et al. Membrane Effects of the n_3 Fish Oil Fatty Acids, which Prevent Fatal Ventricular Arrhythmias. J Membr Biol 2005; 206 (2): 129-39.][Xiao Y.F. et al. The Antiarrhythmic Effect of n_3 Polyunsaturated Fatty Acids: Modulation of Cardiac Ion Channelsas a Potential Mechanism. J Membr Biol 2005; 206 (2): 141-54.][Васильев А.П., Стрельцова H.H., Секисова М.А. и др. Клинико-профилактические аспекты применения омега-3 жирных кислот в медицине. Тюмень: Экспресс, 2010.][Calo L, Biabconi L, Colivicchi F et al. N-3 fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a randomized, controlled trial. J Am Coll Cardiol 2005;45:1723-8.][Singer P, Wirth M. Can omega-3 polyunsaturated fatty acids reduce cardiac arrhythmias? Results of a clinical trial. Prostaglandins Leukot Essent Fatty Acids 2004; 71: 153-9.][Нифонтов Е.М., Шихалиев Д.Р., Богачев М.И. и др. Антиаритмическая эффективность омега-3 полиненасыщенных жирных кислот у больных стабильной ишемической болезнью сердца с желудочковыми нарушениями ритма. Кардиология. 2010; 12: 41-6.][Дженкинс Н.П., Дэвидсон Н.К., Беннет Д.Г. Успешное лечение желудочковой тахикардии, рефрактерной к медикаментозной терапии, при дополнительном назначении препарата омега-3 полиненасыщенных жирных кислот. Обзоры клин. кардиологии. 2009; 18: 10-4.][Biscione F, Totteri A, De Vita A. et al. Effect of omega-3 fatty acids on the prevention of atrial arrhythmias [in Italian]. Ital Heart J (Suppl.) 2005; 6: 53-9.][Chee K.M, Gong J.X, Rees D.M.G. et al. Fatty acid content of marine oil capsules. Lipids 1990; 25 (9): 523-8.][Есинов А.в. омега-3 жирные кислоты в медицине: диагностика, подходы к лечению. Автореф. дис. канд. биол. наук. 2012.][Громова О.А., Торшин И.Ю., Калачева А.Г., Грачева О.Н. Мировой опыт омега-3 ПНЖК. Крупномасштабные клинические исследования омега-3 ПНЖК: об эффективности, доказательности и перспективах. Сердце. 2011; 5: 263-72.]