Consilium MedicumConsilium MedicumConsilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum9503810.26442/2075-1753_2018.4.63-67ArticlesСтатьиReview ArticleChromogranin A in the diagnosis of pheochromocytoma: reviewХромогранин А в диагностике феохромоцитомы: обзор литературыYukinaM. YuЮкинаМарина Юрьевна

канд. мед. наук, вед. науч. сотр. отд. терапевтической эндокринологии

endo-yukina@yandex.ruDavtyanD. AДавтянДиана Аршалуйсовнаdiadavtyan@gmail.comTroshinaE. AТрошинаЕкатерина Анатольевна

чл.-кор. РАН, д-р мед. наук, проф., зав. отд. терапевтической эндокринологии

troshina@inbox.ruPlatonovaN. MПлатоноваНадежда Михайловна

д-р мед. наук, гл. науч. сотр. отд. терапевтической эндокринологии

doc-platonova@inbox.ruNational Medical Research Center of Endocrinology of the Ministry of Health of Russian FederationФГБУ «НМИЦ эндокринологии»15042018204VOL 20, NO4 (2018)ТОМ 20, №4 (2018)63628122021Copyright ©; 2018, Consilium MedicumCopyright ©; 2018, ООО "Консилиум Медикум"2018Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://consilium.orscience.ru/2075-1753/article/view/95038

Pheochromocytoma is a tumor of neuroectodermal origin, which arises from chromaffin cells of the sympatho-adrenal system of the adrenal or extra-аdrenal localization, secreting an excessive amount of catecholamines, and accompanies with the syndrome of hypertension of varying degrees of severity and diverse metabolic disorders. In addition to the synthesis and secretion of catecholamines, these tumors are able to produce a variety of biologically active peptides, including chromogranin A (neuroendocrine secretory protein), which, along with other laboratory tests, can help in the diagnosis of pheochromocytoma.

Феохромоцитома - это опухоль нейроэктодермального происхождения, которая возникает из хромаффинных клеток симпатоадреналовой системы надпочечниковой или вненадпочечниковой локализации, секретирующая избыточное количество катехоламинов, протекающая с синдромом гипертензии разной степени выраженности и многообразными метаболическими расстройствами. Помимо синтеза и секреции катехоламинов эти опухоли способны вырабатывать разные биологически активные пептиды, в том числе и хромогранин А (нейроэндокринный секреторный протеин), который, наряду с другими лабораторными тестами, может помочь в диагностике феохромоцитомы.

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