Consilium MedicumConsilium MedicumConsilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum95084ArticlesСтатьиReview ArticleTrimetazidine (review of the latest foreign publications)Триметазидин (обзор последних зарубежных публикаций)AkatovaE. VАкатоваЕвгения Владимировна

д-р мед. наук, проф. каф. госпитальной терапии №1

akev@list.ruA.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian FederationФГБОУ ВО «МГМСУ им. А.И.Евдокимова»151020182010VOL 20, NO10 (2018)ТОМ 20, №10 (2018)535828122021Copyright ©; 2018, Consilium MedicumCopyright ©; 2018, ООО "Консилиум Медикум"2018Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://consilium.orscience.ru/2075-1753/article/view/95084

Review of the latest data of randomized studies, meta-analyses and experimental studies proving the effectiveness of trimetazidine in cardiovascular diseases and comorbid pathology.

Обзор последних данных рандомизированных исследований, метаанализов и экспериментальных работ, доказывающих эффективность применения триметазидина при сердечно-сосудистых заболеваниях и коморбидной патологии.

trimetazidinecoronary heart diseasecongestive heart failureтриметазидинишемическая болезнь сердцахроническая сердечная недостаточностьTritto I, Wang Pe, Kuppusamy P. The Anti-Anginal Drug Trimetazidine Reduces Neutrophil-Mediated Cardiac Reperfusion Injury. Cardiovasc Pharmacol 2015; 46 (1): 89-98.Jeong Su Kim, Chang Hoon Kim, Kook Jin Chun. Effects of trimetazidine in patients with acute myocardial infarction: data from the Korean Acute Myocardial Infarction Registry. Clin Res Cardiol. DOI 10.1007/s00392-013-0611-0Szwed H, Sadowski Z, Elikowski W. Combination treatment in stable effort angina using trimetazidine and metoprolol Results of a randomized, double-blind, multicentre study (TRIMPOL II). Eur Heart J 2011; 22: 2267-74.Song Peng, Min Zhao, Jing Wan. The efficacy of trimetazidine on stable angina pectoris: A meta-analysis of randomized clinical trials. Int J Cardiol 2014; 177: 780-5.Kyoung-Ha Park, Woo Jung Park, Min-Kyu Kim. Effects of Trimetazidine on Endothelial Dysfunction After Sheath Injury of Radial Artery 2010 Elsevier Inc. Am J Cardiol 2010; 105: 1723-7.Jinsong Chen, Shanshan Zhou, Jing Jin. Chronic treatment with trimetazidine after discharge reduces the incidence of restenosis in patients who received coronary stent implantation: A 1-year prospective follow-up study. DOI: 10.3892/mmr.2016.5773Glezer M.G, Vygodin V.A. Anti-Anginal Effectiveness and Tolerability of Trimetazidine Modified Release 80 Mg Once Daily in Stable Angina Patients in Real-World Practice. On behalf of ODA investigators. Adv Ther. https://doi.org/10.1007/s12325-018-0756-3//Dedkova E.N, Seidlmayer L.K, Blatter L.A. Mitochondria-mediated cardioprotection by trimetazidine in rabbit heart failure. J Mol Cell Cardiol 2013. pii: S0022-2828(13)00054-0. DOI: 10.1016/j.yjmcc.2013.01.016Belardinelli R, Solenghi M, Volpe L. Trimetazidine improves endothelial dysfunction in chronic heart failure: an antioxidant effect. Online publish-ahead-of-print 24 April 2007.Fragasso G, Rosano G, Baek S.H. Effect of partial fatty acid oxidation inhibition with trimetazidine on mortality and morbidity in heart failure: Results from an international multicentre retrospective cohort study. Int J Cardiol 2012. http://dx.doi.org/10.1016/j.ijcard.2012.09.123Dengfeng Gao, Ning Ning, Xiaolin Niu. Trimetazidine: a meta-analysis of randomised controlled trials in heart failure. Heart 2011; 97: 278-86.Lei Zhang, Yizhou Lu, Hong Jiang. Additional Use of Trimetazidine in Patients With Chronic Heart Failure A Meta-Analysis. J Am Col Cardiol 2012; 59 (10).Xiaohan Xu, Weijun Zhang, Yujie Zhou. Effect of Trimetazidine on Recurrent Angina Pectoris and Left Ventricular Structure in Elderly Multivessel Coronary Heart Disease Patients with Diabetes Mellitus After Drug-Eluting Stent Implantation: A Single-Centre, Prospective, Randomized, Double-Blind Study at 2-Year Follow-Up. Springer International Publishing Switzerland 2014. Clin Drug Invest. DOI 10.1007/s40261-014-0170-9