Consilium MedicumConsilium MedicumConsilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum9513110.26442/20751753.2018.12.000009ArticlesСтатьиResearch ArticleAcute renal injury in obstetric practice: focus on atypical hemolytic uremic syndromeОстрое почечное повреждение в акушерской практике: фокус на атипичный гемолитико-уремический синдромKorotchaevaYu. VКоротчаеваЮлия Вячеславовна

доц. каф. внутренних, профессиональных болезней и ревматологии медико-профилактического фак-та

lumis-j@bk.ruKozlovskayaN. LКозловскаяНаталья Львовна

д-р мед. наук, проф., рук. Центра помощи беременным с патологией почек и мочевыделительных путей

nkozlovskaya@yandex.ruI.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian FederationФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М.Сеченова» Минздрава РоссииA.K.Eramishantsev City Clinical Hospital of the Department of Health of MoscowГБУЗ «Городская клиническая больница им. А.К.Ерамишанцева» Департамента здравоохранения г. Москвы.151220182012VOL 20, NO12 (2018)ТОМ 20, №12 (2018)697328122021Copyright ©; 2018, Consilium MedicumCopyright ©; 2018, ООО "Консилиум Медикум"2018Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://consilium.orscience.ru/2075-1753/article/view/95131

Acute kidney injury (AKI) in obstetrics is a serious complication of pregnancy and postpartum period that threatens life of the mother and of the child. In recent decades the percent of AKI associated with thrombotic microangiopathies (TMA) in obstetrics has increased. Among various TMA forms that may develop in the second half of pregnancy and in postpartum period, the worst kidney injury is associated with atypical hemolytic uremic syndrome (AHUS) that is followed with AKI development in 100% of cases. In most patients AHUS is followed by multiple organ dysfunction syndrome. Modern AHUS diagnostics and undelayed start of therapy with eculizumab allows not only to save patients' lives but also to have them recovered

Острое повреждение почек (ОПП) в акушерской практике представляет собой серьезное, угрожающее жизни как матери, так и плода осложнение беременности и послеродового периода. В последние десятилетия в развитых странах растет доля акушерского ОПП, обусловленного тромботическими микроангиопатиями (ТМА). Среди различных форм акушерских ТМА, которые могут появиться во второй половине беременности и после родов, наиболее тяжелое поражение почек развивается при атипичном гемолитико-уремическом синдроме (аГУС), характеризующемся развитием ОПП в 100% случаев. У подавляющего большинства пациенток аГУС протекает с развитием полиорганной недостаточности. Своевременная диагностика аГУС и незамедлительное начало терапии экулизумабом позволяют не только спасти жизнь пациенткам с аГУС, но и полностью восстановить их здоровье

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