Consilium MedicumConsilium MedicumConsilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum9521410.26442/20751753.2019.9.190589ArticlesСтатьиReview ArticleSOME TYPES OF STRUCTURAL (SYMPTOMATIC) EPILEPSY IN ADULTSНЕКОТОРЫЕ ФОРМЫ СИМПТОМАТИЧЕСКИХ (СТРУКТУРНЫХ) ЭПИЛЕПСИЙ У ВЗРОСЛЫХPizovaNatalia V.ПИЗОВАНАТАЛЬЯ ВЯЧЕСЛАВОВНА

д-р мед. наук, проф. каф. нервных болезней с медицинской генетикой и нейрохирургией ФГБОУ ВО ЯГМУ

pizova@yandex.ruYaroslavl State Medical UniversityФГБОУ ВО «Ярославский государственный медицинский университет» Минздрава России15092019219VOL 21, NO9 (2019)ТОМ 21, №9 (2019)586528122021Copyright ©; 2019, Consilium MedicumCopyright ©; 2019, ООО "Консилиум Медикум"2019Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://consilium.orscience.ru/2075-1753/article/view/95214

Epilepsy is a chronic central nervous system disorder. Data on epilepsy in adult patients prevalence in different countries are presented. Underlying mechanisms of epileptogenesis are described. Epileptic seizures in patients after ischemic or hemorrhagic stroke and after traumatic brain injury are described more thoroughly and characteristics of acute seizures as well as late epileptic seizures in these disorders are presented. Data on incidence of epileptic seizures in patients with various brain neoplasms and of interrelations of epilepsy development in these patients depending on tumor localization and histology are given. Guidelines on the use of antiepileptic medications as monotherapy in patients with focal seizures depending on the main process causing development of one or another symptomatic (structural) epilepsy are presented. Convulex® is described in detail.

Эпилепсия - хроническое заболевание центральной нервной системы. Представлены данные о распространенности эпилепсии у взрослых в разных странах. Описаны основные механизмы эпилептогенеза. Более глубоко описаны эпилептические припадки у пациентов с ишемическим или геморрагическим инсультом, после черепно-мозговой травмы и представлены особенности острых приступов, а также поздних эпилептических приступов при этих заболеваниях. Приведены данные о частоте встречаемости эпилептических припадков у пациентов с различными новообразованиями головного мозга, а также о взаимосвязи развития эпилепсии у этих пациентов в зависимости от локализации опухоли и ее гистологии. Представлены рекомендации по применению антиэпилептических препаратов в качестве исходной монотерапии у взрослых с очаговыми припадками и в зависимости от основного процесса, вызывающего развитие той или иной симптоматической (структурной) эпилепсии. Более детально рассмотрен препарат Конвулекс®.

structural (symptomatic) epilepsyacute cerebral eventstraumatic brain injurybrain neoplasmstreatmentструктурная (симптоматическая) эпилепсияострые нарушения головного мозгачерепно-мозговая травмановообразования головного мозгалечениеКарлов В.А. Эпилепсия у детей и взрослых женщин и мужчин. М.: Медицина, 2010. [Karlov V.A. Epilepsy in children and adult women and men. Moscow: Meditsina, 2010 (in Russian).]Fisher RS, Acevedo C, Arzimanoglou A et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia 2014; 55 (4): 475-82.Helmers SL, Thurman DJ, Durgin TL et al. Descriptive epidemiology of epilepsy in the U.S. population: a different approach. Epilepsia 2015; 56: 942-8. DOI: 10.1111/epi.13001Gupta S, Kwan P, Faught E et al. Understanding the burden of idiopathic generalized epilepsy in the United States, Europe, and Brazil: an analysis from the National Health and Wellness Survey. Epilepsy Behav 2016; 55: 146-56. DOI: 10.1016/j.yebeh.2015.12.18Мильчакова Л.Е. 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