Consilium MedicumConsilium MedicumConsilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum9533010.26442/20751753.2020.5.200001ArticlesСтатьиReview ArticleImpact of different medication groups on drug-induced seizures riskВлияние разных групп лекарственных средств на риск развития лекарственно-индуцированных эпилептических приступовOstroumovaTatiana M.ОстроумоваТатьяна Максимовна

канд. мед. наук, ассистент каф. нервных болезней и нейрохирургии Института клинической медицины

AkimovaElizaveta S.АкимоваЕлизавета Сергеевна

студентка 6-го курса лечебного фак-та

KochetkovAleksei I.КочетковАлексей Иванович

канд. мед. наук, доц. каф. терапии и полиморбидной патологии

OstroumovaOlga D.ОстроумоваОльга Дмитриевна

д-р мед. наук, проф., зав. каф. терапии и полиморбидной патологии

ostroumova.olga@mail.ruSechenov First Moscow State Medical University (Sechenov University)ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)Yevdokimov Moscow State University of Medicine and DentistryФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава РоссииRussian Medical Academy of Continuous Professional EducationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России15052020225VOL 22, NO5 (2020)ТОМ 22, №5 (2020)9810528122021Copyright ©; 2020, Consilium MedicumCopyright ©; 2020, ООО "Консилиум Медикум"2020Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://consilium.orscience.ru/2075-1753/article/view/95330

One of the reasons for the development of epileptic seizures (ES) is the effect of certain drugs. Drug-induced ES and status epilepticus can also develop due to administration or withdrawal of a large number of drugs. The most common drug-induced ES are associated with the use of antidepressants, antiepileptic drugs, antibiotics, antitumor drugs, opioid analgesics, anesthetics, etc. Awareness and adequate assessment of the potential risk of the development of drug-induced ES, monitoring and correction of factors that determine and increase the risk of drug-induced ES, as well as the withdrawal or change of drugs that potentially cause ES, are the most important preventive measures to prevent the development of drug-induced ES and status epilepticus. Key words: epileptic seizures, drug-induced seizures, adverse drug reactions. For citation: Ostroumova Т.М., Akimova E.S., Kochetkov A.I., Ostroumova O.D. Impact of different medication groups on drug-induced seizures risk. Consilium Medicum. 2020; 22 (5): 98-105. DOI: 10.26442/20751753.2020.5.200001

Одной из причин развития эпилептических приступов (ЭП) является воздействие тех или иных лекарственных средств. Лекарственно-индуцированные ЭП (ЛИЭП) и эпилептический статус могут также развиваться на фоне приема или отмены достаточно большого ряда препаратов. Наиболее часто возникновение ЛИЭП ассоциировано с приемом антидепрессантов, противоэпилептических препаратов, антибиотиков, противоопухолевых препаратов, опиоидных анальгетиков, анестетиков и др. Осведомленность и адекватная оценка потенциального риска развития ЛИЭП на фоне назначенных пациенту препаратов, мониторирование и коррекция факторов, определяющих и повышающих риск возникновения ЛИЭП, а также отмена или замена лекарственных средств, потенциально вызывающих ЭП, при развитии ЛИЭП, являются важнейшими лечебно-профилактическими мероприятиями, позволяющими предотвратить развитие ЛИЭП и эпилептического статуса. Ключевые слова: эпилептические приступы, лекарственно-индуцированные эпилептические приступы, нежелательные побочные реакции. Для цитирования: Остроумова Т.М., Акимова Е.С., Кочетков А.И., Остроумова О.Д. Влияние разных групп лекарственных средств на риск развития лекарственно-индуцированных эпилептических приступов. Consilium Medicum. 2020; 22 (5): 98-105. DOI: 10.26442/20751753.2020.5.200001

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