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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Consilium Medicum</journal-id><journal-title-group><journal-title xml:lang="en">Consilium Medicum</journal-title><trans-title-group xml:lang="ru"><trans-title>Consilium Medicum</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Consilium Medicum</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-1753</issn><issn publication-format="electronic">2542-2170</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">95355</article-id><article-id pub-id-type="doi">10.26442/20751753.2020.9.200459</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Goals and possibilities of combined hypolipidemic therapy of cerebrovascular diseases associated with dyslipidemia</article-title><trans-title-group xml:lang="ru"><trans-title>Цели и возможности комбинированной гиполипидемической терапии цереброваскулярных заболеваний, ассоциированных с дислипидемией</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sabirov</surname><given-names>Ibragim S.</given-names></name><name xml:lang="ru"><surname>Сабиров</surname><given-names>Ибрагим Самижонович</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, проф., рук. каф. терапии №2 специальности «Лечебное дело»</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Murkamilov</surname><given-names>Ilkhom T.</given-names></name><name xml:lang="ru"><surname>Муркамилов</surname><given-names>Илхом Торобекович</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, нефролог, и. о. доц. каф. факультетской терапии</p></bio><email>murkamilov.i@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fomin</surname><given-names>Viktor V.</given-names></name><name xml:lang="ru"><surname>Фомин</surname><given-names>Виктор Викторович</given-names></name></name-alternatives><bio xml:lang="ru"><p>чл.-кор. РАН, д-р мед. наук, проф., рук. каф. факультетской терапии №1, проректор по клинической работе и дополнительному профессиональному образованию</p></bio><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Yusupov</surname><given-names>Furkat A.</given-names></name><name xml:lang="ru"><surname>Юсупов</surname><given-names>Фуркат Абдулахатович</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, проф., рук. каф. неврологии, нейрохирургии и психиатрии медицинского фак-та</p></bio><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kyrgyz-Russian Slavic University</institution></aff><aff><institution xml:lang="ru">ГОУ ВПО «Кыргызско-Российский славянский университет им. Первого Президента Российской Федерации Б.Н. Ельцина»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Akhunbaev Kyrgyz State Medical Academy</institution></aff><aff><institution xml:lang="ru">Кыргызская государственная медицинская академия им. И.К. Ахунбаева</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Sechenov First Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Osh State University</institution></aff><aff><institution xml:lang="ru">Ошский государственный университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2020-09-15" publication-format="electronic"><day>15</day><month>09</month><year>2020</year></pub-date><volume>22</volume><issue>9</issue><issue-title xml:lang="en">VOL 9, NO22 (2020)</issue-title><issue-title xml:lang="ru">ТОМ 22, №9 (2020)</issue-title><fpage>46</fpage><lpage>51</lpage><history><date date-type="received" iso-8601-date="2021-12-28"><day>28</day><month>12</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2020, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2020, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://consilium.orscience.ru/2075-1753/article/view/95355">https://consilium.orscience.ru/2075-1753/article/view/95355</self-uri><abstract xml:lang="en"><p>The article presents a review of the literature on the goals and possibilities of statin and nonstatin hypolipidemic therapy, as well as their combination in cerebrovascular diseases associated with dyslipidemia. The issues of safety of the combined lipid-lowering strategy on the possibility of primary and secondary prevention of cerebrovascular accidents (ischemic and hemorrhagic strokes, as well as transient ischemic attack) are discussed.</p></abstract><trans-abstract xml:lang="ru"><p>Представлен обзор литературы, посвященный целям и возможностям статиновой и нестатиновой гиполипидемической терапии, а также их комбинирования при цереброваскулярных заболеваниях, ассоциированных с дислипидемией. Обсуждаются вопросы безопасности комбинированной ли-пидснижающей стратегии, возможности первичной и вторичной профилактики нарушений мозгового кровообращения (ишемического и геморрагического инсультов, а также транзиторной ишемической атаки).</p></trans-abstract><kwd-group xml:lang="en"><kwd>atherosclerotic disease</kwd><kwd>dyslipidemia</kwd><kwd>cerebrovascular disease</kwd><kwd>stroke</kwd><kwd>statins</kwd><kwd>ezetimibe</kwd><kwd>inhibitors of the protein convertase subtilisin/kexin type 9 (PCSK9)</kwd><kwd>combined hypolipidemic therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>атеросклеротическая болезнь</kwd><kwd>дислипидемия</kwd><kwd>цереброваскулярные заболевания</kwd><kwd>инсульт</kwd><kwd>статины</kwd><kwd>эзетимиб</kwd><kwd>ингибиторы протеиновой конвертазы субтилизин/кексин типа 9 (PCSK9)</kwd><kwd>комбинированная гиполипидемическая терапия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Дюжева Е.В. 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