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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Consilium Medicum</journal-id><journal-title-group><journal-title xml:lang="en">Consilium Medicum</journal-title><trans-title-group xml:lang="ru"><trans-title>Consilium Medicum</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Consilium Medicum</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-1753</issn><issn publication-format="electronic">2542-2170</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">95390</article-id><article-id pub-id-type="doi">10.26442/20751753.2021.2.200651</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Traditional and rare causes of ischemic stroke in 18 to 50-year old persons</article-title><trans-title-group xml:lang="ru"><trans-title>Традиционные и редкие причины ишемического инсульта у лиц 18-50 лет</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pizov</surname><given-names>Nikolai A.</given-names></name><name xml:lang="ru"><surname>Пизов</surname><given-names>Николай Александрович</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант каф.</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Skachkova</surname><given-names>Olga A.</given-names></name><name xml:lang="ru"><surname>Скачкова</surname><given-names>Ольга Александровна</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант каф.</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pizova</surname><given-names>Nataliia V.</given-names></name><name xml:lang="ru"><surname>Пизова</surname><given-names>Наталия Вячеславовна</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, проф. каф.</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Baranova</surname><given-names>Natalia S.</given-names></name><name xml:lang="ru"><surname>Баранова</surname><given-names>Наталья Сергеевна</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, проф. каф.</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Yaroslavl State Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Ярославский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2021</year></pub-date><volume>23</volume><issue>2</issue><issue-title xml:lang="en">VOL 23, NO2 (2021)</issue-title><issue-title xml:lang="ru">ТОМ 23, №2 (2021)</issue-title><fpage>122</fpage><lpage>126</lpage><history><date date-type="received" iso-8601-date="2021-12-28"><day>28</day><month>12</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://consilium.orscience.ru/2075-1753/article/view/95390">https://consilium.orscience.ru/2075-1753/article/view/95390</self-uri><abstract xml:lang="en"><p>The article discusses the epidemiological data on the incidence of ischemic stroke (IS) in persons aged 18-50 years, the frequency of various subtypes of IS, depending on the region according to the TOAST classification. Based on recent studies, the frequency of the main traditional risk factors for IS in young people is given, as well as our own data on the frequency of detection of various subtypes of IS on admission and the main risk factors in 145 people aged 18-45 years. The article describes other, moderate causes of stroke at a young age, taking into account modern diagnostic capabilities.</p></abstract><trans-abstract xml:lang="ru"><p>Рассмотрены эпидемиологические данные о заболеваемости ишемическим инсультом (ИИ) лиц в возрасте 18-50 лет, о том, как часто наблюдаются различные подтипы ИИ в зависимости от региона согласно классификации TOAST. На основании различных исследований последних лет представлена частота встречаемости основных, традиционных факторов риска развития ИИ в молодом возрасте. Приведены собственные данные о частоте выявляемости на момент поступления различных подтипов ИИ, а также основных факторов риска у 145 лиц в возрасте 18-45 лет. Описаны другие, более редкие причины развития инсульта в молодом возрасте с учетом современных диагностических возможностей.</p></trans-abstract><kwd-group xml:lang="en"><kwd>ischemic stroke</kwd><kwd>young age</kwd><kwd>traditional and rare causes</kwd><kwd>risk factors</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>ишемический инсульт</kwd><kwd>молодой возраст</kwd><kwd>традиционные и редкие причины</kwd><kwd>факторы риска</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Katan M, Luft A Global Burden ofStroke. Semin Neurol. 2018; 38 (2): 208-11. DOI: 10.1055/s-0038-1649503</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Feigin VL, Norrving B, Mensah GA. Global Burden of Stroke. Circ Res. 2017; 120 (3): 439-48. DOI: 10.1161/CIRCRESAHA.116.308413</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>GBD 2015 Neurological Disorders Collaborator Group Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Neurol. 2017; 16: 877-97. DOI: 10.1016/S1474-4422(17)30299-5</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>World Health Organization. Projections of mortality and causes of death, 2015 and 2030. Health statistics and information systems. 2013. Available at: http://www.who.int/entity/healthinfo/glo-bal_burden_disease/GHE_DthGlobal_Proj_2015_2030.xls?ua=1. Accessed: 15.07.2013.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Aslanyan S, Weir CJ, Lees KR, et al. Effect of area-based deprivation on the severity, subtype, and outcome of ischemic stroke. Stroke. 2003; 34: 2623-8. DOI: 10.1161/01.STR.0000097610.12803.D7</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Wu SH, Woo J, Zhang X-H. Worldwide socioeconomic status and stroke mortality: an ecological study. IntJ Equity Health. 2013; 12: 42. DOI: 10.1186/1475-9276-12-42</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Bejot Y, Bailly H, Durier J, Giroud M. Epidemiology of stroke in Europe and trends for the 21st century. Presse Med. 2016; 45: e391-8.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Feigin VL, Roth GA, Naghavi M. Global burden of stroke and risk factors in 188 countries, during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet Neurol. 2016; 15: 913-24.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Bejot Y, Daubail B, Jacquin A. Trends in the incidence of ischaemic stroke in young adults between 1985 and 2011: the Dijon stroke registry. J NeurolNeurosurg Psychiatry. 2014; 85: 509-13.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Griffiths D, Sturm J. Epidemiology and etiology of young stroke. Stroke Res Treat. 2011; 2011: 1-9.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Lo WD, Kumar R. Arterial ischemic stroke in children and young adults. Continuum(MinneapMinn). 2017; 23: 158-80.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Cabral NL, Freire AT, Conforto AB. Increase of stroke incidence in young adults in a middle-income country: a 10-year population-based study. Stroke. 2017; 48: 2925-30.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Putaala J, Martinez-Majander N, Saeed S, et al. Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Triggers, Causes, and Outcome (SECRETO): rationale and design. Eur Stroke J. 2017; 2: 116-25.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Putaala J. Ischemic Stroke in Young Adults. Continuum (Minneap Minn). 2020; 26 (2): 386-414. DOI: 10.1212/CON.0000000000000833</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>George MG. Risk Factors for Ischemic Stroke in Younger Adults - a Focused Update. Stroke. 2020;(3): 729-35. DOI: 10.1161/STROKEAHA.119.024156</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Пизова Н.В., Скачкова О.А., Пизов Н.А., и др. Криптогенный инсульт в молодом возрасте: диагностические трудности и новые терапевтические возможности. Поликлиника. 2019; 3: 18-22</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Adams HP, Bendixen BH, Kappelle LJ,et al. Classification of subtype of acute ischemic stroke definitions for use in a multicenter clinical trial. Stroke. 1993; 24: 35-41.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Cerrato P, Grasso M, Imperiale D, et al. Stroke in young patients: etiopathogenesis and risk factors in different age classes. Cerebrovasc Dis. 2004; 18: 154-9. DOI: 10.1159/000079735</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Nedeltchev K, der Maur TA, Georgiadis D, et al. Ischaemic stroke in young adults: predictors of outcome and recurrence. J Neurol Neurosurg Psychiatry. 2005; 76: 191-5. DOI: 10.1136/jnnp.2004.040543</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Rasura M, Spalloni A, Ferrari M, et al. A case series of young stroke in Rome. Eur J Neurol. 2006; 13: 146-52. DOI: 10.1111/j.1468-1331.2006.01159</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Varona JF, Guerra JM, Bermejo F, et al. Causes of ischemic stroke in young adults, and evolution of the etiological diagnosis over the long term. Eur Neurol. 2007; 57: 212-18. DOI: 10.1159/000099161</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Jovanovic DR, Beslac-Bumbasirevic L, Raicevic R, et al. Etiology of ischemic stroke among young adults of Serbia. VojnosanitPregl. 2008; 65: 803-9. DOI: 10.2298/VSP0811803J</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Putaala J, Metso AJ, Metso TM, et al. Analysis of 1008 consecutive patients aged 15 to 49 with first-ever ischemic stroke: the Helsinki Young Stroke Registry. Stroke. 2009; 40 (4): 1195-203. DOI: 10.1161/STROKEAHA.108.529883</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Spengos K, Vemmos K. Risk factors, etiology, and outcome of first-ever ischemic stroke in young adults aged 15 to 45 - the Athens Young Stroke Registry. Eur J Neurol. 2010; 17 (11): 1358-64. DOI: 10.1111/j.1468-1331.2010.03065</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Tancredi L, Martinelli Boneschi F, Braga M, et al. Stroke care in young patients. Stroke Res Treat. 2013; 2013: 715380. DOI: 10.1155/2013/715380</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Barlas YN, Putaala J, Waje-Andreassen U, et al. Etiology of first ever ischaemic stroke in European young adults: the 15 Cities Young Stroke Study. EurJ Neurol. 2013; 20 (11): 1431-9. DOI: 10.1111/ene.12228</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Singhal AB, Biller J, Elkind MS, et al. Recognition and management of stroke in young adults and adolescents. Neurology. 2013; 81: 1089-97.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>George MG, Tong X, Bowman BA. Prevalence of cardiovascular risk factors and strokes in younger adults. JAMA Neurology. 2017; 74: 695-703.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Kivioja R, Pietila A, Martinez-Majander N, et al. Risk factors for early-onset ischemic stroke: a casecontrol study. J Am Heart Assoc. 2018; e009774.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Aigner A, Grittner U, Rolfs A, et al. Contribution of established stroke risk factors to the burden of stroke in young adults. Stroke. 2017; 48: 1744-51. DOI: 10.1161/STROKEAHA.117.016599</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Putaala J, Yesilot N, Waje-Andreassen U, et al. Demographic and geographic vascular risk factor differences in European young adults with ischemic stroke: the 15 Cities Young Stroke Study. Stroke. 2012; 43: 2624-30.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Zhang YN, He L. Risk factors study of ischemic stroke in young adults in Southwest China. Sichuan Da Xue Xue Bao Yi Xue Ban. 2012; 43: 553-7.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Wu TY, Kumar A, Wong EH. Young ischaemic stroke in South Auckland: a hospital-based study. N ZMedJ. 2012; 125: 47-56.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Tang M, Yao M, Zhu Y, et al. Sex differences of ischemic stroke in young adults - A single-center Chinese cohort study. JStroke Cerebrovasc Dis. 2020; 29 (9): 105087. DOI: 10.1016/j.jstrokecerebrovasdis.2020.105087</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Renna R, Pilato F, Profice P,et al. Risk factor and etiology analysis of ischemic stroke in young adult patients. J Stroke Cerebrovasc Dis. 2014; 23 (3): e221-7. DOI: 10.1016/j.jstrokecerebrovasdis.2013.10.008</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Calvet D. Ischemic stroke in the young adult. Rev Med Interne. 2016; 37 (1): 19-24. DOI: 10.1016/j.revmed.2015.08.004</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Mackay MT, Wiznitzer M, Benedict SL, et al. Arterial ischemic stroke risk factors: the International Pediatric Stroke Study. Ann Neurol. 2011; 69: 130-40.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Van Alebeek ME, Arntz RM, Ekker MS, et al. Risk factors and mechanisms of stroke in young adults: The FUTURE study. J Cereb Blood Flow Metab. 2018; 38 (9): 1631-41. DOI: 10.1177/0271678X17707138</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Maaijwee NA, Rutten-Jacobs LC, Schaapsmeerders P,et al. Ischaemic stroke in young adults: risk factors and long-term consequences. Nat Rev Neurol. 2014; 10: 315-25.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Rutten-Jacobs LC, Maaijwee NA, Arntz RM, et al. Risk factors and prognosis of young stroke. The FUTURE study: a prospective cohort study. Study rationale and protocol. BMC Neurol. 2011; 11: 109.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Smajlovic D. Strokes in young adults: epidemiology and prevention. Vasc Health RiskManag. 2015; 11: 157-64. DOI: 10.2147/VHRM.S53203</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Пизова Н.В. Редкие причины инсульта в молодом возрасте. Медицинский алфавит. 2016; 2 (14): 41-6</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Пизова Н.В. Ишемический инсульт и наследственные тромбофилические состояния. Анналы клинической и экспериментальной неврологии. 2017; 11 (4): 71-80</mixed-citation></ref></ref-list></back></article>
