Consilium MedicumConsilium MedicumConsilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum9541910.26442/20751753.2021.2.200665ArticlesСтатьиReview ArticleVitamin D and multiple sclerosisВитамин D и рассеянный склерозCheredanovaViktoriia R.ЧередановаВиктория Романовна

студентка

vcheredanova@yandex.ruChabinIvan A.ЧабинИван Андреевич

студент

BembeevaRaisa Ts.БембееваРаиса Цеденкаевна

д-р мед. наук, проф. каф.

Sechenov First Moscow State Medical University (Sechenov University)ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)Pirogov Russian National Research Medical UniversityФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России15022021232VOL 23, NO2 (2021)ТОМ 23, №2 (2021)16516928122021Copyright ©; 2021, Consilium MedicumCopyright ©; 2021, ООО "Консилиум Медикум"2021Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://consilium.orscience.ru/2075-1753/article/view/95419

Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system and is a major cause of disability in able-bodied young people. Recently, the question of the effect of vitamin D on the risk of occurrence and clinical course of MS has been widely discussed. The review presents pathogenesis of this disease and estimated mechanisms of the effect of cholecalciferol on it, current data on the effect of vitamin D levels on the risk of MS, the course and outcome of this disease.

Рассеянный склероз (РС) - это аутоиммунное заболевание, поражающее центральную нервную систему и являющееся основной причиной инвалидизации трудоспособных молодых людей. В последнее время широко обсуждаются вопросы влияния витамина D на риск возникновения и клиническое течение РС. В обзоре рассмотрены патогенез этого заболевания и предположительные механизмы влияния на него хо-лекальциферола, представлены современные данные о влиянии уровня витамина D на риск развития РС, течение и исход этого заболевания.

multiple sclerosisvitamin Dautoimmune diseaseрассеянный склерозвитамин Dаутоиммунное заболеваниеBoyko A, Smirnova N, Petrov S, Gusev E. Epidemiology of MS in Russia, a historical review. Mult Scler Demyelinating Disord. 2016; 1: 1-6. DOI: 10.1186/s40893-016-0016-9Попова Е., Бойко А., Барабанова М. Первично-прогрессирующий рассеянный склероз: современное состояние проблемы своевременной постановки диагноза. Журн. неврологии и психиатрии им. С.С. Корсакова. 2017; 117: 35-40 [Popova E, Boyko A, Barabanova M. Primary progressive multiple sclerosis: Current issues of timely diagnosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2017; 117: 35-40 (in Russian)]. DOI: 10.17116/jnevro201711710235-40Feige J, Moser T, Bieler L, et al. Vitamin D Supplementation in Multiple Sclerosis: A Critical Analysis of Potentials and Threats. Nutrients. 2020; 12 (3): 783. DOI: 10.3390/nu12030783Dendrou CA, Fugger L, Friese MA. Immunopathology of multiple sclerosis. Nat Rev Immunol. 2015; 15: 545-58. DOI: 10.1038/nri3871Beckmann Y, Ture S, Duman SU. Vitamin D deficiency and its association with fatigue and quality of life in multiple sclerosis patients. EPMA Journal. 2020;11: 65-72. DOI: 10.1007/s13167-019-00191-0Tarlinton RE, Khaibullin T, Granatov E, et al. The interaction between viral and environmental risk factors in the pathogenesis of multiple sclerosis. Int J Mol Sci. 2019; 20 (2): 303. DOI: 10.3390/ijms20020303Dobson R, Giovannoni G. Multiple sclerosis - a review. Eur J Neurol. 2019; 26 (1): 27-40. DOI: 10.1111/ene.13819Thompson AJ, Baranzini SE, Geurts J, Hemmer B. Multiple sclerosis. Lancet. 2018; 391 (10130): 1622-36. DOI: 10.1016/S0140-6736(18)30481-1Sospedra M, Martin R. Immunology of Multiple Sclerosis. Semin Neurol. 2016; 36 (02): 1 15-27. DOI: 10.1055/s-0036-1579739Miclea A, Bagnoud M, Chan A, Hoepner R. A Brief Review of the Effects of Vitamin D on Multiple Sclerosis. Front Immunol. 2020: 781. DOI: 10.3389/fimmu.2020.00781Витебская А.В., Тихая М.И. Дефицит витамина D и аутоиммунные заболевания. Доктор.ру. 2017; 4 (133): 45-8Парахонский А.П. Иммуномодулирующие эффекты витамина D. Заметки ученого. 2015: 180-7Smolders J, Torkildsen, Camu W. An Update on Vitamin D and Disease Activity in Multiple Sclerosis. CNS Drugs. 2019; 33: 1187-99. DOI: 10.1007/s40263-019-00674-8Каронова Т.Л., Шмонина И.А., Тотолян Н.А. Рассеянный склероз и уровень обеспеченности витамином D. Артериальная гипертензия. 2015; 21 (2): 121-9Yadav SK, Mindur JE, Ito K, Dhib-Jalbut S. Advances in the immunopathogenesis of multiple sclerosis. Curr Opin Neurology 2015; 28 (3): 206-19. DOI: 10.1097/WCO.0000000000000205Пигарова Е.А., Плещева А.В. Влияние витамина D на иммунную систему. Иммунология. 2015; 1: 62-6Пигарова Е.А., Петрушкина А.А. Неклассические эффекты витамина D. Остеопороз и остеопатии. 2017; 20 (3): 90-101Pierrot-Deseilligny C, Souberbielle JC. Vitamin D and multiple sclerosis: An update. MultSclerRelat Disord. 2017; 14: 35-45. DOI: 10.1016/j.msard.2017.03.014Ramagopalan SV, Dobson R, Meier UC, Giovannoni G. Multiple sclerosis: risk factors, prodromes, and potential causal pathways. Lancet Neurol. 2010; 9 (7): 727-39. DOI: 10.1016/S1474^422(10)70094-6Munger KL, Zhang SM, O’Reilly E, et al. Vitamin D intake and incidence of multiple sclerosis. Neurology. 2004; 62 (1): 60-5. DOI: 10.1212/01.WNL.0000101723.79681.38Munger KL, Levin LI, Hollis BW, et al. A Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA. 2006; 296 (23): 2832-8. DOI: 10.1001/jama.296.23.2832Клинические рекомендации. Дефицит витамина D у взрослых: диагностика, лечение и профилактика. 2015Salzer J, Hallmans G, Nystrom M, et al. Vitamin D as a protective factor in multiple sclerosis. Neurology. 2012; 79: 2140-5. DOI: 10.1212/WNL.0b013e3182752ea8Decard BF, Von Ahsen N, Grunwald T, et al. Low vitamin D and elevated immunoreactivity against Epstein-Barr virus before first clinical manifestation of multiple sclerosis. J Neurol Neurosurg Psychiatr. 2012; 83: 1170-3. DOI: 10.1136/jnnp-2012-303068Bhargava P, Steele SU, Waubant E, et al. Multiple sclerosis patients have a diminished serologic response to Vitamin D supplementation compared to healthy controls. Mult Scler J. 2016; 22: 753-60. DOI: 10.1177/1352458515600248Mirzaei F, Michels KB, Munger K, et al. Gestational vitamin D and the risk of multiple sclerosis in offspring. Ann Neurol. 2011; 70: 30-40. DOI: 10.1002/ana.22456Munger KL, Aivo J, Hongell K, et al. Vitamin D status during pregnancy and risk of multiple sclerosis in offspring of women in the Finnish Maternity Cohort. JAMA. 2016; 73: 515-9. DOI: 10.1001/jamaneurol.2015.4800Cortese M, Riise T, Bjornevik K, et al. Timing of use of cod liver oil, a vitamin D source, and multiple sclerosis risk: The EnvIMS study. Mult Scler J. 2015; 21: 1856-64. DOI: 10.1177/1352458515578770Baarnhielm M, Olsson T, Alfredsson L. Fatty fish intake is associated with decreased occurrence of multiple sclerosis. Mult Scler J. 2014; 20: 726-32. DOI: 10.1177/1352458513509508Simpson S, Blizzard L, Otahal P, et al. Latitude is significantly associated with the prevalence of multiple sclerosis: A meta-analysis. J Neurol Neurosurg Psychiatr. 2011; 82: 1132-41. DOI: 10.1136/jnnp.2011.240432Martinez-Lapiscina EH, Mahatanan R, Lee CH, et al. Associations of serum 25(OH) vitamin D levels with clinical and radiological outcomes in multiple sclerosis, a systematic review and meta-analysis. J Neurol Sci. 2020; 411: 116668. DOI: 10.1016/j.jns.2020.116668Cortese M, Munger KL, Martinez-Lapiscina EH, et al. Vitamin D, smoking, EBV, and long-term cognitive performance in MS: 11-year follow-up of BENEFIT. Neurology. 2020; 94 (18): e1950-60. DOI: 10.1212/WNL.0000000000009371Yochum A, Movva K. Does vitamin D supplementation in patients with relapsing-remitting multiple sclerosis decrease the number of relapses? Evidence-Based Pract Ovid Technologies. 2020; 23 (5): 34-5. DOI: 10.1097/EBP.0000000000000279Kampman MT, Steffensen LH, Mellgren SI, Jorgensen L. Effect of vitamin D3 supplementation on relapses, disease progression, and measures of function in persons with multiple sclerosis: Exploratory outcomes from a double-blind randomised controlled trial. Mult Scler J. 2012; 18: 1144-51. DOI: 10.1177/1352458511434607Stein MS, Liu Y, Gray OM, et al. A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis. Neurology. 2011; 77: 1611-8. DOI: 10.1212/WNL.0b013e3182343274Dorr J, Backer-Koduah P, Wernecke K-D, et al. High-dose vitamin D supplementation in multiple sclerosis - results from the randomized EVIDIMS (efficacy of vitamin D supplementation in multiple sclerosis) trial. Mult Scler J - Exp Transl Clin. 2020; 6 (1). DOI: 10.1177/2055217320903474Ashtari F, Toghianifar N, Zarkesh-Esfahani SH, Mansourian M. High dose Vitamin D intake and quality of life in relapsing-remitting multiple sclerosis: a randomized, double-blind, placebo-controlled clinical trial. Neurol Res. 2016; 38 (10): 888-92. DOI: 10.1080/01616412.2016.1227913Does evidence support Vitamin D treatment for multiple sclerosis? DTB. 2019; 57: 163. DOI: 10.1136/dtb.2019.000070Mclaughlin L, Clarke L, Khalilidehkordi E, et al. Vitamin D in the treatment of multiple sclerosis: A meta-analysis. J Neurol Neurosurg Psychiatr. 2017; 88(5): e1.95-e1. DOI: 10.1136/jnnp-2017-316074.92Hupperts R, Smolders J, Vieth R, et al. Randomized trial of daily high-dose Vitamin D3 in patients with RRMS receiving subcutaneous interferon 0-1a. Neurology. 2019; 93 (20): E1906-16. DOI: 10.1212/WNL.0000000000008445Camu W, Lehert P, Pierrot-Deseilligny C, et al. Cholecalciferol in relapsing-remitting MS: A randomized clinical trial (CHOLINE). Neurol Neuroimmunol Neuroinflamm. 2019; 6 (5): e597. DOI: 10.1212/NXI.0000000000000597Muris AH, Smolders J, Rolf L, et al. Immune regulatory effects of high dose vitamin D3 supplementation in a randomized controlled trial in relapsing remitting multiple sclerosis patients receiving IFN0; the SOLARIUM study. J Neuroimmunol. 2016; 300: 47-56. DOI: 10.1016/j.jneuroim.2016.09.018Feige J, Salmhofer H, Hecker C, et al. Life-threatening vitamin D intoxication due to intake of ultra-high doses in multiple sclerosis: A note of caution. Mult Scler J. 2019; 25: 1326-8. DOI: 10.1177/1352458518807059Fragoso YD, Adoni T, Damasceno A, et al. Unfavorable outcomes during treatment of multiple sclerosis with high doses of vitamin D. J Neurolog Sci. 2014; 346 (1-2): 341-2. DOI: 10.1016/j.jns.2014.08.019Bittker SS. Elevated levels of 1,25-dihydroxyvitamin D in plasma as a missing risk factor for celiac disease. Clin Exp Gastroenterol. 2020; 13: 1-15. DOI: 10.2147/CEG.S222353Institute of Medicine. 2011. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: The National Academies Press, 2011. DOI: 10.17226/13050Atkinson SA, Fleet JC. Canadian recommendations for vitamin D intake for persons affected by multiple sclerosis. J Steroid Biochem Mol Biol. 2020; 199: 105606. DOI: 10.1016/j.jsbmb.2020.105606