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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Consilium Medicum</journal-id><journal-title-group><journal-title xml:lang="en">Consilium Medicum</journal-title><trans-title-group xml:lang="ru"><trans-title>Consilium Medicum</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>Consilium Medicum</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-1753</issn><issn publication-format="electronic">2542-2170</issn><publisher><publisher-name xml:lang="en">Consilium Medicum</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">95462</article-id><article-id pub-id-type="doi">10.26442/20751753.2021.3.200774</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Antiseptics as an alternative to systemic antibiotic therapy</article-title><trans-title-group xml:lang="ru"><trans-title>Антисептики как альтернатива системной антибактериальной терапии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ryazantsev</surname><given-names>Sergey V.</given-names></name><name xml:lang="ru"><surname>Рязанцев</surname><given-names>Сергей Валентинович</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, проф., зам. дир.</p></bio><email>professor.ryazantsev@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pavlova</surname><given-names>Svetlana S.</given-names></name><name xml:lang="ru"><surname>Павлова</surname><given-names>Светлана Сергеевна</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-оториноларинголог, мл. науч. сотр.</p></bio><email>s-ultraviolet@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Eremin</surname><given-names>Sergey A.</given-names></name><name xml:lang="ru"><surname>Еремин</surname><given-names>Сергей Алексеевич</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, науч. сотр. отд.</p></bio><email>eremin-lor@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gorpinich</surname><given-names>Valery D.</given-names></name><name xml:lang="ru"><surname>Горпинич</surname><given-names>Валерий Дмитриевич</given-names></name></name-alternatives><bio xml:lang="ru"><p>ординатор второго года обучения</p></bio><email>gvalera251@bk.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Saint Petersburg Research Institute of Ear, Throat, Nose and Speech</institution></aff><aff><institution xml:lang="ru">ФГБУ «Санкт-Петербургский научно-исследовательский институт уха, горла, носа и речи» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-03-15" publication-format="electronic"><day>15</day><month>03</month><year>2021</year></pub-date><volume>23</volume><issue>3</issue><issue-title xml:lang="en">VOL 23, NO3 (2021)</issue-title><issue-title xml:lang="ru">ТОМ 23, №3 (2021)</issue-title><fpage>256</fpage><lpage>260</lpage><history><date date-type="received" iso-8601-date="2021-12-28"><day>28</day><month>12</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://consilium.orscience.ru/2075-1753/article/view/95462">https://consilium.orscience.ru/2075-1753/article/view/95462</self-uri><abstract xml:lang="en"><p>Sore throat is one of the most frequent reasons for going to the doctor and prescribing irrational antibacterial therapy. The reasons for this are many -from the difficulties of etiological diagnosis and the development of relapses and possible severe complications to the personal attitude of doctors and patients to the choice of treatment. At the same time, the issue of antibiotic resistance, side effects associated with the appointment of antibacterial therapy, is one of the most important problems of modern health care around the world. Difficulties in the process of clinical observation of patients, the peculiarities of the course of infectious and inflammatory diseases of the pharynx are factors requiring constant improvement of methods of providing medical care. Antiseptics play a significant role in the treatment of sore throat, exceeding the frequency of use of antibiotics. So, one of the antiseptics used topically, the effectiveness of which has been proven in clinical studies, is Strepsils, which includes 2,4-dichlorobenzyl alcohol and amylmetacresol. The results of clinical studies of the drug indicate its positive effect in patients with sore throat. All this things allow us to recommend that this complex antiseptic be more often included in the treatment of infectious and inflammatory diseases of the oral cavity and pharynx.</p></abstract><trans-abstract xml:lang="ru"><p>Боль в горле - один из наиболее частых поводов обращения к врачу и назначения нерациональной антибактериальной терапии. Причин этому множество - от трудностей этиологической диагностики и развития рецидивов и возможных тяжелых осложнений до личностного отношения врачей и пациентов к выбору лечения. Вместе с тем вопрос антибиотикорезистентности, побочных эффектов, связанных с назначением антибактериальной терапии, является одной из важнейших проблем современного здравоохранения во всем мире. Сложности в процессе клинического наблюдения пациентов, особенности течения инфекционно-воспалительных заболеваний глотки - факторы, требующие постоянного совершенствования методов оказания медицинской помощи. Существенную роль при лечении боли в горле играют антисептики. Так, один из антисептиков, применяемых местно, эффективность которого доказано в клинических исследованиях, - препарат Стрепсилс, в состав которого входят 2,4-дихлорбензиловый спирт и амилметакрезол. Результаты клинических исследований препарата свидетельствуют о его положительном эффекте у пациентов с острым фарингитом, что позволяет рекомендовать шире включать в комплекс лечения инфекционно-воспалительных заболеваний полости рта и глотки данный комплексный антисептический препарат.</p></trans-abstract><kwd-group xml:lang="en"><kwd>sore throat</kwd><kwd>antibiotic</kwd><kwd>antiseptics</kwd><kwd>infectious and inflammatory diseases of the pharynx</kwd><kwd>throat microbiome</kwd><kwd>topical therapy</kwd><kwd>amylmetacresol</kwd><kwd>dichlorobenzyl alcohol</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>боль в горле</kwd><kwd>антибиотики</kwd><kwd>антисептики</kwd><kwd>инфекционно-воспалительные заболевания глотки</kwd><kwd>микробиом глотки</kwd><kwd>топическая терапия</kwd><kwd>амилметакрезол</kwd><kwd>дихлорбензиловый спирт</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Choby BA. 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