Consilium MedicumConsilium MedicumConsilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum9677010.26442/20751753.2019.11.190641ArticlesСтатьиReview ArticlePossibilities of regenerative medicine in otorhinolaryngology (literature review)Возможности регенеративной медицины в оториноларингологии (обзор литературы)SvistushkinValerii M.СвистушкинВалерий Михайлович

D. Sci. (Med.), Prof.

д-р мед. наук, проф., зав. каф. болезней уха, горла и носа Института клинической медицины

svvm3@yandex.ruStarostinaSvetlana V.СтаростинаСветлана Викторовна

D. Sci. (Med.), Prof.

д-р мед. наук, проф. каф. болезней уха, горла и носа Института клинической медицины

SvistushkinMikhail V.СвистушкинМихаил Валерьевич

Аssistant

ассистент каф. болезней уха, горла и носа Института клинической медицины

PobivantsevaAnna A.ПобиванцеваАнна Андреевна

Clinical Resident

клинический ординатор

www.vesta.ru@mail.ruArkhipovMaksim V.АрхиповМаксим Владимирович

Student

студент 6-го курса Института здоровья детей

Sechenov First Moscow State Medical University (Sechenov University)ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)151120192111VOL 21, NO11 (2019)ТОМ 21, №11 (2019)151919012022Copyright ©; 2019, Consilium MedicumCopyright ©; 2019, ООО "Консилиум Медикум"2019Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://consilium.orscience.ru/2075-1753/article/view/96770

During last 30 years the tissue engineering from theoretical area of scientific interest turned into the wide practical field for experiment. Skin, bone tissue, cartilage, blood vessels are just some examples of organs and tissues that, thanks to regenerative medicine, can be created in the laboratory. At the moment it is difficult to find a field of medicine where the development of tissue engineering and cell therapy would not be in demand. Otolaryngology is no exception. Globally for researchers in regenerative medicine, there are 3 areas of interest: the study of cells, the possibility of using native and synthesized bio-scaffolds, the use of various recombinant growth factors and other cellular targets. The possibilities of regenerative medicine in the field of otolaryngology are extremely wide, which is explained by the large variability of diseases. Otiatry, rhinology, laryngology - dozens of promising preclinical and clinical studies are being conducted in each of the areas today, the results of which in the near future will significantly expand the use of minimally invasive treatment methods. One of the few factors holding back even more rapid development of this area remains the imperfection of the regulatory framework and the discrepancy between the quality of preclinical studies and the requirements of ethical committees. Many open questions require immediate solutions, because the promise of continuing research towards the development of regenerative technologies is obvious. The restoration of tissues and their functions in otorhinolaryngology with the methods of regenerative medicine will make it possible to solve problems that previously seemed impossible.

За последние 30 лет тканевая инженерия из теоретической области научного интереса превратилась в широкое экспериментальное поле для деятельности. Кожа, костная ткань, хрящи, сосуды - это лишь некоторые примеры органов и тканей, которые возможно создать в лаборатории благодаря регенеративной медицине. На данный момент сложно найти область медицины, где бы разработки тканевой инженерии и клеточной терапии не были востребованы; оториноларингология не стала исключением. Глобально для исследователей в регенеративной медицине существует 3 области интереса: изучение клеток, возможность использования нативных и синтезируемых биокаркасов (скаффолдов), применение различных рекомбинантных факторов роста и других клеточных мишеней. Возможности регенеративной медицины в области оториноларингологии крайне широки, что объясняется большой вариативностью ЛОР-патологий. Отиатрия, ринология, ларингология - в каждой из областей сегодня проводятся десятки перспективных доклинических и клинических исследований, результаты которых уже в ближайшем будущем существенно расширят применение малоинвазивных методов лечения. Одними из немногих факторов, сдерживающих еще более стремительное развитие данной области, остаются несовершенство нормативно-правового регулирования и несоответствие качества доклинических исследований требованиям этических комитетов. Многие открытые вопросы требуют решений: перспективность продолжения исследований в направлении развития регенеративных технологий очевидна. Восстановление тканей и их функций в оториноларингологии методами регенеративной медицины позволит решить задачи, которые раньше казались невыполнимыми.

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