Consilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum9684910.26442/20751753.2019.6.190430Research ArticleTherapeutic benefit of PRP-therapy in treatment of atrophic vaginitis and vulva lichen sclerosusIvanovaElena V.Cand. Sci. (Med.)DoctorIvanovaEV@gmail.comSozaevaLarisa G.Cand. Sci. (Med.)-Clinical Institute of Aesthetic MedicineRussian Medical Academy of Continuous Professional Education15062019216778019012022Copyright © 2019, Consilium Medicum2019Preservation of women’s health in different age periods, especially in the time of menopausal changes is one of the pressing problems in gynecology. Genitourinary menopausal syndrome is a complex of symptoms developing in estrogen-dependent tissues in women not only of peri- and postmenopausal age but also at time of lactation amenorrhea and treatment of genitourinary system hormone-associated disorders in reproductive age. The pathogenic basis for syndrome therapy is the use of estrogen-containing preparations for topical use. Although some women have contraindications for estrogens use because of impaired extragenital physical status. Platelet-rich plasma (PRP) therapy is widely used as an alternative treatment method.plasma therapyPRP-therapyaesthetical gynecologygenitourinary syndromevulva lichen sclerosusплазмотерапияPRP-терапияэстетическая гинекологиягенитоуринарный синдромсклероатрофический лишай вульвы[Сметник В.П. Критерии репродуктивного старения. Гинекология. 2009; 11 (5): 4-9. @@Smetnik V.P. Kriterii reproduktivnogo stareniia. Gynecology. 2009; 11 (5): 4-9. (in Russian)][Faubion S.S, Sood R, Kapoor E. Genitourinary Syndrome of Menopause: Management Strategies for the Clinician. Mayo Clin Proc 2017; 92 (12): 1842-9. DOI: 10.1016/j.mayocp.2017.08.019][Dhillon R.S, Schwarz E.M, Maloney M.D. Platelet-rich plasma therapy: future or trend? Arthritis Res Ther 2012; 14: 219.][Lai L.P, Stitik T.P, Foye P.M et al. Use of platelet-rich plasma in intra-articular knee injections for osteoarthritis: a systematic review. PM R 2015; 7: 637-48.][Dhurat R, Sukesh M. Principles and methods of preparation of platelet-rich plasma: a review and author's perspective. J Cutan Aesthet Surg 2014; 7: 189-97.][International Cellular Medicine Society. Platelet Rich plasma (PRP) guidelines [Internet] Las Vegas: International Cellular Medicine Society, 2011.][Sundman E.A, Cole B.J, Karas V et al. The anti-inflammatory and matrix restorative mechanisms of platelet-rich plasma in osteoarthritis. Am J Sports Med 2014; 42: 35-41.][Аполихина И.А., Саидова А.С., Кубицкая Ю.В. Способ лечения стрессового и смешанного типов недержания мочи у женщин. М., 2010; с. 2-3. @@Apolikhina I.A., Saidova A.S., Kubitskaia Iu.V. A method for the treatment of stress and mixed types of urinary incontinence in women. Moscow, 2010; p. 2-3 (in Russian)][Аполихина И.А., Соколова А.В., Саидова А.С., Горбунова Е.А. Аутологичная плазма, обогащенная тромбоцитами, в сочетании с гиалуроновой кислотой - новый метод малоинвазивного лечения стрессового недержания мочи у женщин. Мед. совет. 2018; 13: 16-20. @@Apolikhina I.A., Sokolova A.V., Saidova A.S., Gorbunova E.A. Autologichnaia plazma, obogashchennaia trombotsitami, v sochetanii s gialuronovoi kislotoi - novyi metod maloinvazivnogo lecheniia stressovogo nederzhaniia mochi u zhenshchin. Med. sovet. 2018; 13: 16-20 (in Russian)][Everts P.A, Hoogbergen M.M, Weber T.A et al. Is the use of autologous platelet-rich plasma gels in gynecologic, cardiac, and general, reconstructive surgery beneficial? Curr Pharm Biotechnol 2012; 13: 1163-72.][Casabona F, Priano V, Vallerino V et al. New surgical approach to lichen sclerosus of the vulva: the role of adipose-derived mesenchymal cells and platelet-rich plasma in tissue regeneration. Plast Reconstr Surg 2010; 126: 210e-211.]