Consilium MedicumConsilium MedicumConsilium MedicumConsilium Medicum2075-17532542-2170Consilium Medicum9689410.26442/20751753.2019.2.180147ArticlesСтатьиResearch ArticlePathophysiologic aspects of resorption of intervertebral disk herniaПатофизиологические аспекты резорбции грыж межпозвонкового дискаTkachevAlexsander M.ТкачевАлександр Михайлович

neurologist

врач-невролог

tkachevclinic@gmail.comEpifanovAnton V.ЕпифановАнтон Вячеславович

neurologist

врач-невролог, Клиника Доктора Епифанова

epifus@mail.ruAkarachkovaElena S.АкарачковаЕлена Сергеевна

D. Sci. (Med.), Corr. Memb. RANS, president

чл.-кор. РАЕ, д-р мед. наук, президент

nevrorus@mail.ruSmirnovaAlina V.СмирноваАлина Вячеславовна

radiologis

врач-рентгенолог

smirnova-av@ldc.ruIliushinArtem V.ИлюшинАртем Владимирович

radiologist

врач-рентгенолог

ArchakovDaniil S.АрчаковДаниил Сергеевич

psychiatrist

врач-психиатр

danielsarch@yandex.ruDr.Berezin Medical InstituteООО «ЛДЦ МИБС», Клиника ТкачеваKlinika TkachevaКлиника Доктора ЕпифановаKlinika Doktora EpifanovaМеждународное общество «Стресс под контролем»International Society of Stress “Stress under Control”ООО «ЛДЦ МИБС»Dr.Berezin Medical InstituteООО «ЛДЦ МИБС»Dr.Berezin Medical InstituteКлиника ТкачеваKlinika Tkacheva15022019212VOL 21, NO2 (2019)ТОМ 21, №2 (2019)596319012022Copyright ©; 2019, Consilium MedicumCopyright ©; 2019, ООО "Консилиум Медикум"2019Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://consilium.orscience.ru/2075-1753/article/view/96894

Spinal disc herniation is a pathological anatomical disorder that is associated with localized disk displacement beyond the intervertebral space. Although in most cases surgical intervention is not necessary for recovery, it still has an important role in this disorder treatment. In most patients a course of conservative treatment results in symptoms improvement and in some patients it allows to eliminate symptoms completely. Nevertheless the underlying mechanisms of this spontaneous improvement are still underexplored, though they may provide therapeutic potential that may speed up the recovery process and prevent development of long-term complications. The article considers in detail the origins of inflammatory response in spinal disc herniation development as well as interrelation between spinal disc herniation resorption and symptomatic improvement. Necessity for conduction of future research on the role of inflammatory response in spinal disc herniation formation and resorption is shown. It is important because understanding the reason why most of the patients recover without surgical intervention can speed up the recovery processes and allow many patients to avoid surgical treatment that will also result in improvement of quality of life in this group.

Межпозвонковая грыжа - это патологическое анатомическое нарушение, которое определяется локализованным смещением диска за пределы межпозвоночного промежутка. Хотя в большинстве случаев операция не считается необходимым условием для выздоровления, оперативное вмешательство играет важную роль в лечении этого заболевания. У большинства пациентов улучшается состояние после консервативного лечения, а некоторые полностью избавляются от симптомов болезни. Тем не менее механизмы, лежащие в основе такого спонтанного улучшения состояния, все еще мало изучены, но они открывают терапевтические потенциалы, которые могут ускорить процесс восстановления и предотвратить долгосрочные осложнения. Подробно рассмотрена природа воспалительной реакции при образовании межпозвонковой грыжи, описано химическое обоснование поясничной радикулопатии, а также взаимосвязь между резорбцией межпозвонковой грыжи и симптоматическим улучшением. Показана необходимость проведения дальнейших исследований роли воспалительной реакции в формировании и резорбции межпозвонковых грыж, так как понимание, почему большинство пациентов восстанавливаются без операции, поможет ускорить процесс восстановления и избавит многих пациентов от хирургического вмешательства, что также будет способствовать улучшению качества жизни данной категории пациентов.

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