Objective. To evaluate correlation of measured diffusion coefficient – MDC (tumor MDC and MDS ratio) with final malignancy degree after radical prostatectomy (RP).
Materials and methods. The study included 118 patients with prostate cancer in whom RP was performed between 2012 and 2017 after 3 Tesla contrast-enhanced multiparametric magnetic resonance imaging (mpMRI) in one medical center. After MRI results analysis mean MDC of tumor tissue (tumor MDC) and normal tissue (normal tissue MDC) were determined according to MDC records and MDC ratio was calculated (division of tumor MDC by normal tissue MDC).
Results. A significant negative moderate correlation (Spearman correlation coefficient = -0.733, p=0.000) was found between tumor MDC and postoperative tumor cells differentiation degree. Similar correlation was also found for MDS ratio with higher Spearman correlation coefficient = -0.802, p=0.000. In ROC-analysis of PC discrimination Gleason 6 from Gleason ≥7 area under ROC-curve (AUC) for tumor MDC was 0.898 (95% confidence interval – CI 0.835–0.961) and for MDC ratio – 0.950 (95% CI 0.909–0.992). When tumor MDC≥0,78 was used as a criteria for Gleason 6 (grade group 1) sensitivity was 78% and specificity – 98%. When MDC rate ≥0.4501 was used sensitivity and specificity comprised 92 and 93%, respectively.
Conclusion. When measured in postoperative pathomorphological study tumor MDC measurement has significant negative correlation with final malignancy rate of PC Gleason 6 (grade group 1). MDS ratio had somewhat stronger correlation that is more precise after Gleason score division 6 (3+3) from ≥(3+4).
Key words: prostate cancer, Gleason scale, multiparametric magnetic resonance imaging, measured diffusion coefficient.
For citation: Goncharuk D.A., Veliev E.I., Sokolov E.A. et al. Assessment of measured in multiparametric magnetic resonance imaging diffusion coefficient potential for low malignancy score determination in PC after radical prostatectomy. Consilium Medicum. 2018; 20 (7): 15–19. DOI: 10.26442/2075-1753_2018.7.15-19
About the Author
D.A.Goncharuk*1, E.I.Veliev1,2, E.A.Sokolov1,2, I.V.Shabunin3, O.V.Paklina2, G.R.Setdikova2
1Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation. 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1;
2S.P.Botkin City Сlinical Hospital of the Department of Health of Moscow. 125284, Russian Federation, Moscow, 2-i Botkinskii pr-d, d. 5;
3Medical and diagnostic center “Patero-Clinic”. 129226, Russian Federation, Moscow, pr. Mira, d. 211, k. 2
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Publisher: ZAO "Consilium Medicum"