Association of the VNTR polymorphism in the MIR137 gene with cognitive functions in schizophrenia patients and healthy individuals

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The study aimed to analyze the associations between cognitive domains impaired in schizophrenia and the rs58335419 polymorphism located within the schizophrenia GWAS-significant locus, in the gene MIR137 encoding miR-137. Schizophrenia spectrum patients (n = 787) and healthy volunteers without a family history of psychosis (n = 622) completed tests of semantic verbal fluency (VF), attention/working memory, verbal episodic memory, and executive functions. After correction for multiple testing, VF abnormalities were associated with homozygosity for the common allele (with three repeats) in male patients. Similar trends occurred in the pooled sample for attention/working memory and the general index of cognitive functioning. The four-repeat allele was not associated with variance in cognitive performance. The results obtained indicate an association between homozygosity for the common allele at rs58335419 and lower levels of cognitive functions, which is opposite to the effect of this polymorphism on the risk of developing schizophrenia.

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M. Alfimova

Mental Health Research Center

编辑信件的主要联系方式.
Email: m.alfimova@gmail.com
俄罗斯联邦, Moscow

G. Korovaitseva

Mental Health Research Center

Email: m.alfimova@gmail.com
俄罗斯联邦, Moscow

V. Plakunova

Mental Health Research Center

Email: m.alfimova@gmail.com
俄罗斯联邦, Moscow

V. Golimbet

Mental Health Research Center

Email: m.alfimova@gmail.com
俄罗斯联邦, Moscow

参考

  1. Trubetskoy V., Pardiña A.F., Qi T. et al. Mapping genomic loci implicates genes and synaptic biology in schizophrenia // Nature. 2022. V. 604. P. 502–508. https://doi.org/10.1038/s41586-022-04434-5
  2. Pacheco A., Berger R., Freedman R., Law A.J. A VNTR regulates miR-137 expression through novel alternative splicing and contributes to risk for schizophrenia // Sci. Rep. 2019. V. 9. № 1. P. 11793–11804. https://doi.org/10.1038/s41598-019-48141-0
  3. Коровайцева Г.И., Олейчик И.В., Лежейко Т.В., Голимбет В.Е. Изучение ассоциации VNTR-полиморфизма rs58335419 гена MIR137 с риском развития шизофрении // Генетика 2024. Т. 60. № 2. С. 63–69. https://doi.org/10.31857/S0016675824020065.
  4. Mahmoudi E., Atkins J.R., Quidé Y. et al. The MIR137 VNTR rs58335419 is associated with cognitive impairment in schizophrenia and altered cortical morphology // Schizophr. Bull. 2021. V. 47. № 2. P. 495–504. https://doi.org/10.1093/schbul/sbaa123
  5. Savage J.E., Jansen P.R., Stringer S. et al. Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence // Nat. Genet. 2018. V. 50. P. 912–919. https://doi.org/10.1038/s41588-018-0152-6
  6. Cummings E., Donohoe G., Hargreaves A. et al. Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the novel schizophrenia risk variant at MIR-137 // Neurosci. Lett. 2013. V. 532. P. 33–38. https://doi.org/10.1016/j.neulet.2012.08.065
  7. Kuswanto C.N., Sum M.Y., Qiu A. et al. The impact of genome wide supported microRNA-137 (MIR137) risk variants on frontal and striatal white matter integrity, neurocognitive functioning, and negative symptoms in schizophrenia // Am. J. Med. Genet. B. Neuropsychiatr. Genet. 2015. V. 168B. P. 317–326. https://doi.org/10.1002/ajmg.b.32314
  8. Cosgrove D., Harold D., Mothersill O. et al. MiR-137-derived polygenic risk: effects on cognitive performance in patients with schizophrenia and controls // Transl. Psychiatry. 2017. V. 7. № 1. Р. e1012. https://doi.org/10.1038/tp.2016.286
  9. Van Erp T.G.M., Guella I., Vawter M.P. et al. Schizophrenia miR-137 locus risk genotype is associated with DLPFC hyperactivation // Biol. Psychiatry. 2014. V. 75. № 5. P. 398–405. https://doi.org/10.1016/j.biopsych.2013.06.016
  10. Kandratsenka H., Nestsiarovich A., Goloenko I. et al. Association of MIR137 with symptom severity and cognitive functioning in Belarusian shizophrenia patients // Front. Psychiatry. 2018. V. 9. https://doi.org/10.3389/fpsyt.2018.00295
  11. González-Giraldo Y., González-Reyes R.E., Forero D.A. A functional variant in MIR137, a candidate gene for schizophrenia, affects Stroop test performance in young adults // Psychiatry. Res. 2016. V. 236. P. 202–205. https://doi.org/10.1016/j.psychres.2016.01.006
  12. Алфимова М.В., Кондратьев Н.В., Голов А.К., Голимбет В.Е. Метилирование ДНК в локусе MIR137HG, ассоциированном с шизофренией и интеллектом, может быть связано с заболеванием и когнитивными функциями // Генетика. 2019. Т. 55. № 2. С. 207–213.
  13. JASP (version 0.18.3) [Computer software]. 2024. https://jasp-stats.org/, дата обращения 01.03.2024.
  14. Kim H.Y. Statistical notes for clinical researchers: Assessing normal distribution (2) using skewness and kurtosis // Restor. Dent. Endod. 2013. V. 38. P. 52–54. https://doi.org/10.5395/rde.2013.38.1.52
  15. Grinkevich L.N. The role of microRNAs in learning and long-term memory // Vavilov J. Genet. and Breeding. 2020. V. 24. № 8. https://doi.org/10.18699/VJ20.687
  16. Liu X., Dong L., Jiang Z. et al. Identifying the differentially expressed peripheral blood microRNAs in psychiatric disorders: A systematic review and meta-analysis. // Front. Psychiatry. 2024. V. 15. https://doi.org/10.3389/fpsyt.2024.1390366
  17. Peng Q., Dai Z., Yin J. et al. Schizophrenia plausible protective effect of microRNA-137 is potentially related to estrogen and prolactin in female patients // Front. Psychiatry. 2023. V. 14. https://doi.org/10.3389/fpsyt.2023.1187111
  18. García-Cerro S., Gómez-Garrido A., Garcia G. et al. Exploratory analysis of microRNA alterations in a neurodevelopmental mouse model for autism spectrum disorder and chizophrenia // Int. J. Mol. Sci. 2024. V. 25. № 5. https://doi.org/10.3390/ijms25052786

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