Adsorption complexes of vancomycin with nanodiamonds: formation kinetics, composition, and antimicrobial properties

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Adsorption complexes of vancomycin with detonation nanodiamonds having positive and negative surface charges are obtained. The kinetics of vancomycin adsorption on nanodiamonds is described by a pseudo-second-order equation with close parameters for both types of nanodiamonds. The kinetics of vancomycin-nanodiamond complex formation is described by a pseudo-first order equation. Methods of radioactive indicators and IR spectroscopy are used to find that a part of vancomycin is firmly bound to the surface of nanodiamonds and is not removed by washing. The amount of firmly bound matter is found to be three times greater for the complexes with negative nanodiamonds. However, the retention strength of vancomycin on positive nanodiamonds was higher and its content practically did not change during desorption for 10 days. Both types of complexes have the same antimicrobial properties against Staphylococcus aureus. The totality of the obtained data confirms the assumption that the formation of hydrogen bonds with water molecules plays a key role in the adsorption and retention of vancomycin on the surface of nanodiamonds.

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作者简介

Т. Shen

M. V. Lomonosov Moscow State University

Email: chernyshevamg@my.msu.ru
俄罗斯联邦, Moscow, 119991

M. Chernysheva

M. V. Lomonosov Moscow State University

编辑信件的主要联系方式.
Email: chernyshevamg@my.msu.ru
俄罗斯联邦, Moscow, 119991

A. Popov

M. V. Lomonosov Moscow State University

Email: chernyshevamg@my.msu.ru
俄罗斯联邦, Moscow, 119991

I. Chashchin

A. N. Bakulev Scientific Center for Cardiovascular Surgery; A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences

Email: chernyshevamg@my.msu.ru
俄罗斯联邦, Moscow, 119334; Moscow, 119334

N. Anuchina

A. N. Bakulev Scientific Center for Cardiovascular Surgery

Email: chernyshevamg@my.msu.ru
俄罗斯联邦, Moscow, 119334

G. Badun

M. V. Lomonosov Moscow State University

Email: chernyshevamg@my.msu.ru
俄罗斯联邦, Moscow, 119991

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2. Fig. 1. Time dependences of vancomycin adsorption on DHA (a) and SDND (b) nanodiamonds.

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3. Fig. 2. Time dependences of firmly bound vancomycin on DHA (a) and SDND (b) nanodiamonds.

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4. Fig. 3. IR spectra of DHA (1), DHA-vancomycin complex (2) and vancomycin (3).

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5. Fig. 4. IR spectra of SDND (1), SDND-vancomycin complex (2) and vancomycin (3).

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