Synthesis and Biological Activity of 1-Hydroxyethyl- and 1-(4-Hydroxyphenyl)-5-Aryl-4-Aroyl-3-Pyrrolin-2-Ones

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

New 1-(2-hydroxyethyl)- and 1-(4-hydroxyphenyl)-5-aryl-4-aroyl-3-hydroxy-3-pyrroline-2-ones were synthesized by the reaction of methyl esters of aroylpyruvic acids, aromatic aldehydes and ethanolamine (p-aminophenol). The antimicrobial and antinociceptive activity of the obtained compounds was studied.

作者简介

V. Gein

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia

V. Batov

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia

D. Rubtsov

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia

N. Nosova

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation; Perm State Medical University named after Academician E. A. Wagner of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia; Perm, 614990 Russia

I. Mokrushin

Perm State National Research University

Email: geinvl48@mail.ru
Perm, 614068 Russia

L. Gein

Perm State Medical University named after Academician E. A. Wagner of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia

A. Gagarina

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia

V. Novikova

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia

R. Makhmudov

Perm State National Research University; Federal Scientific Center for Medical and Preventive Technologies for Health Risk Management

编辑信件的主要联系方式.
Email: geinvl48@mail.ru
Perm, 614068 Russia; Perm, 614045 Russia

参考

  1. Машковский М.Д. Лекарственные средства. М.: Новая волна, 2008, 826 c.
  2. Сысоев Ю.И., Титович И.А., Оковитый С.В., Лалаев Б.Ю., Болотова В.Ц., Кимаев А.Н., Загладкина Е.В. // Фармация. 2019. Т. 68. №1. С. 48. doi: 10.29296/25419218-2019-01-07
  3. Fang H., Li M., Wang X., Chen W., He F., Zhang Y., Guo K., Jin W., Li B., Fang M. // Bioorg. Chem. 2023. Vol. 141. P. 106887. doi: 10.1016/j.bioorg.2023.106887
  4. Chen B., Wei W., Ma L., Yang B., Gill R.M., Chua M.S., Butte A.J., So S. // Gastroenterology. 2017. Vol. 152. N 8. P. 2022. doi: 10.1053/j.gastro.2017.02.039
  5. Hinson J.A., Roberts D.W., James L.P. In: Adverse Drug Reactions. Handbook of Experimental Pharmacology. 2010. Vol 196. P. 369. doi: 10.1007/978-3-642-00663-0_12
  6. Bender R.P., Lindsey R.H., Jr., Burden D.A., Osheroff N. // Biochemistry. 2004. Vol. 43. N 12. P. 3731. doi: 10.1021/bi036107r
  7. Lisouskaya M., Antipova O.A., Zhavoronok I.P., Mikhalchuk A. // Bioorg. Med. Chem. Lett. 2025. Vol. 117. P. 130080. doi: 10.1016/j.bmcl.2024.130080
  8. Rafique B., Kalsoom S., Sajini A.A., Ismail H., Iqbal M. // Molecules. 2022. Vol. 27. N 4. P. 1352. doi: 10.3390/molecules27041352
  9. Mascagna D., Ghanem G., Morandini R., dʼIschia M., Misuraca G., Lejeune F., Prota G. // Melanoma Res. 1992. Vol. 2. N 1. P. 25. doi: 10.1097/00008390-199205000-00004
  10. López-Pérez A., Freischem S., Grimm I., Weiergräber O., Dingley A.J., López-Alberca M.P., Waldmann H., Vollmer W., Kumar K., Vuong C. // Antibiotics. 2021. Vol. 10. Р. 529. doi: 10.3390/antibiotics10050529
  11. Tobinaga H., Kameyama T., Asahi K., Oohara M., Kobayashi N., Ohdan M., Ishizuka N., Kume M., Tomari M., Tanaka Y., Takahashi F., Kinoshita H., Shimada S., Shinohara S., Kai H. // Bioorg. Med. Chem. Lett. 2018. Vol. 28. N 13. P. 2338. doi: 10.1016/j.bmcl.2017.04.060
  12. Liu T., Dai C., Sang H., Chen F., Huang Y., Liao H., Liu S., Zhu Q., Yang J. // Eur. J. Med. Chem. 2020. Vol. 199. Р. 112334. doi: 10.1016/j.ejmech.2020.112334
  13. Tran N.N., Viet D.V., Mechler A., Thi H.N., Vo Q. // RSC Adv. 2022. Vol. 12. N 38. Р. 24579. doi: 10.1039/d2ra04640g
  14. Nguyen N.T., Dai V.V., Tri N.N., Van Meervelt L., Trung N.T., Dehaen W. // Beilstein J. Org. Chem. 2022. Vol. 18. N 1. P. 1140. doi: 10.3762/bjoc.18.118
  15. Paul S., Das S., Mitra B., Chandra P.G., Ghosh P. // RSC Adv. 2023. Vol. 13. N 8. Р. 5457. doi: 10.1039/d2ra08054k
  16. Esmailzadeh S., Setamdideh D. // J. Serb. Chem. Soc. 2021. Vol. 86. N 11. P. 1039. doi: 10.2298/JSC21
  17. Dutta A., Rohman M.A., Nongrum R., Thongni A., Mitra S., Nongkhlaw R. // New J. Chem. 2021. Vol. 45. P. 8136. doi: 10.1039/d1nj00343g
  18. Гейн В.Л. Тетрагидропиррол- и тетрагидрофуран-2,3-дионы. Пермь: ПГФА, 2004. 130 с.
  19. Гейн В.Л., Бобровская О.В., Машкина Е.А., Новикова В.В., Махмудов Р.Р., Янкин А.Н., Данилов С.Е., Хволис Е.А., Белоногова В.Д., Гуляев Д.К. // ЖОХ. 2020. Т. 90. № 5. С. 723; Gein V.L., Bobrovskaya O.V., Mashkina E.A., Novikova V.V., Hvolis E.A., Belonogova V.D., Gulyaev D.K., Makhmudov R.R., Yankin A.N., Danilov S.E. // Russ. J. Gen. Chem. 2020. Т. 90. № 5. С. 822. doi: 10.1134/S1070363220050102
  20. Гейн О.Н., Рубцова Д.Д., Гейн В.Л. // Хим.-фарм. ж. 2022. Т. 56. № 12. С. 35. doi: 10.30906/0023-1134-2022-56-12-35-37; Gein O.N., Rubtsova D.D., Gein V.L. // Pharm. Chem. J. 2023. Vol. 56. N 12. P. 1604. doi: 10.1007/s11094-023-02833-0

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Russian Academy of Sciences, 2025