Enviar artigo por via de e-mail Synthesis of Substituted Thienopyrimidinones Based on 2-Amino-4-(1,4-benzodioxan-2-yl) Thiophene-3-carboxylic Acid Ethyl Ester
- Autores: Vardanyan S.O.1, Avagyan A.S.1, Sargsyan A.B.1, Harutyunyan S.A.1, Gasparyan H.V.1, Aghekyan A.A.1
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Afiliações:
- Scientific Technological Center of Organic and Pharmaceutical Chemistry of the NAS of the Republic of Armenia
- Edição: Volume 61, Nº 4 (2025)
- Páginas: 447-452
- Seção: ЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИ
- URL: https://consilium.orscience.ru/0514-7492/article/view/689667
- DOI: https://doi.org/10.31857/S0514749225040109
- EDN: https://elibrary.ru/SEAFNB
- ID: 689667
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Resumo
The previously obtained N-arylamides of 2-amino-4-(1,4-benzodioxan-2-yl)thiophene-3-carboxylic acid ethyl ester were cyclized to 2-aryl-substituted 3-aminothienopyrimidin-4-ones by the action of hydrazine hydrate. By condensation of the starting amino ester with chloroacetic acid chloride was obtained chloramide, which was converted by the action of piperidine and morpholine into the corresponding aminomethylamides. The latters were also subjected to cyclization with hydrazine hydrate to 3-aminothienopyrimidin-4-one derivatives with aminomethyl substituents in the second position. The antihypoxic activity of the synthesized compounds was studied.
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Sobre autores
Svetlana Vardanyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry of the NAS of the Republic of Armenia
Email: avagal@mail.ru
ORCID ID: 0000-0003-4582-7629
Armênia, 26, Azatutyan Ave., Yerevan, 0014
Alina Avagyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry of the NAS of the Republic of Armenia
Autor responsável pela correspondência
Email: avagal@mail.ru
ORCID ID: 0000-0002-7148-3666
Armênia, 26, Azatutyan Ave., Yerevan, 0014
Amalya Sargsyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry of the NAS of the Republic of Armenia
Email: avagal@mail.ru
ORCID ID: 0000-0001-7115-9164
Armênia, 26, Azatutyan Ave., Yerevan, 0014
Seda Harutyunyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry of the NAS of the Republic of Armenia
Email: avagal@mail.ru
ORCID ID: 0000-0003-3748-6975
Armênia, 26, Azatutyan Ave., Yerevan, 0014
Hrachik Gasparyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry of the NAS of the Republic of Armenia
Email: avagal@mail.ru
ORCID ID: 0000-0002-8555-3733
Armênia, 26, Azatutyan Ave., Yerevan, 0014
Asya Aghekyan
Scientific Technological Center of Organic and Pharmaceutical Chemistry of the NAS of the Republic of Armenia
Email: avagal@mail.ru
ORCID ID: 0000-0001-6151-4951
Armênia, 26, Azatutyan Ave., Yerevan, 0014
Bibliografia
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