Vol 19, No 7-1 (2017)

The paper discusses current data on epidemiology, pathogenesis, and clinical manifestations of chronic venous disease of the lower extremities. A comparative analysis of various phlebotrophic drugs for the treatment of manifestations of chronic venous disease and chronic venous insufficiency, discusses the benefits of micronized purified flavonoid fraction for the treatment of all classes of chronic venous diseases.

Osteomyelitis remains a complex problem of modern surgery, despite complex approaches to its prevention and treatment, the number of infectious complications in fractures reaches 12%, and recurrence of the disease - 30%. The article presents experimental work, the goal, which was the study of new approaches to the treatment of chronic osteomyelitis, based on the use of ultrasound treatment and collagen. The study was carried out on 210 white rats in 5 groups: in the 1st control group, the treatment of chronic osteomyelitis was not performed, in the 2nd control group the surgical sanation of the focus was performed, in the 1st experimental group, surgical sanation with ultrasonic treatment was used, in the 2nd group After the surgical sanation collagen was introduced into the experimental group, in the third test group, ultrasound treatment was performed together with the collagen. The developed complex method of treatment of chronic osteomyelitis, based on the use of ultrasound treatment and collagen, to the 120th day allows to normalize the general condition of animals, to shorten the healing time of defects. The parameters of clinical blood analysis are normalized, the balance of oxidative stress is observed, the indices of mineral metabolism testify to the active process of bone structure resorption and subsequent osteogenesis. As a result of the X-ray study, a decrease in the zones of osteoporosis and osteosclerosis is revealed, clear boundaries of the cortical layer are traced, there are no sequestrants and defects are filled with new bone tissue. Morphological examination accelerates the synthesis of collagen, the formation of granulation tissue, improved microcirculation, there is a resorption of infiltration. Morphometric results of the study indicate an increase in the isolation of bone and prevention of bone structure redistribution.

Ventilator-associated pneumonia is one of the current problems of intensive care due to high prevalence, insufficient treatment effectiveness, additional costs associated with lengthening stay in the intensive care unit and inpatient. Antibiotic therapy significantly reduces mortality and costs, provided that it is adequate in spectrum and optimality for duration. This analytical review is devoted to the discussion of the optimal duration of antibiotic therapy.