Vol 17, No 1 (2015)

The article presents the definition, classification and pathogenetic mechanisms of cognitive impairment in patients with arterial hypertension (AH). Discusses the literature on the relationship of hypertension with risk of dementia. The possibilities of antihypertensive therapy in the prevention of dementia. Discussed in detail the results of the study Syst-Eur (Systolic Hypertension in Europe), in which the calcium antagonist (CA) nitrendipine ± enalapril reduced the risk of developing dementia, including Alzheimer's disease, new cases, 50%. Neuroprotective action mechanisms are considered as a whole and AK nitrendipine in particular.

Diseases of the cardiovascular system, including the leading place is occupied arterial hypertension (AH), making the most significant contribution to the statistics of fatal and disabling complications in the industrialized world, including in Russia. For the treatment of hypertension, according to domestic and European recommendations, 5 main groups of drugs, are applied including a significant role for blockers of the renin-angiotensin-aldosterone system. Among the angiotensin converting enzyme inhibitors deserved place on clinical effectiveness, organo properties and safety profile belongs fosinopril - lipophilic drug with a dual route of elimination. These properties fosinopril have sufficient evidentiary basis, and despite the large variety of drugs in this group, fosinopril has its own niche in the treatment of hypertensive patients, including those with concomitant chronic kidney disease, chronic heart failure, and has future prospects.

Modern data on clinic variants of the course, complications, differentiated treatment of hypertensive crises.

Материал подготовлен А.Л.Комаровым (д-р мед. наук, вед. науч. сотр. лаб. атеротромбоза НИИ кардиологии ФГБУ РКНПК) и О.О.Шахматовой (канд. мед. наук, мл. науч. сотр. лаб. атеротромбоза НИИ кардиологии ФГБУ РКНПК) по статье Montalescot G, van't Hof AW, Lapostolle F et al. Prehospital ticagrelor in ST -segment elevation myocardial infarction. N Engl J Med 2014; 371: 1016-27

The paper presents an algorithm of examination of the patient to decide on the appointment of statins for the treatment of dyslipidemia and atherosclerosis. The criteria of the effectiveness of statin therapy. The advantages of atorvastatin and rosuvastatin. We discuss the choice of a statin for the treatment of selected patients with changes in blood lipid spectrum.

The article deals with the problem of lifestyle modification in patients with diabetes mellitus, the connection between type 2 diabetes and cardiovascular disease, the causes of unsatisfactory noncompliance many patients with diabetes with regard to lifestyle changes and recommended medical treatment. The role of health professionals in the treatment of patients, the value of structured training programs for the treatment of type 2 diabetes patients is emphasized the need for education in schools diabetic patients, the importance of self-control and an individual approach to each patient specialists to improve the quality of life.

The article analyzes information of the prevalence, causes and mechanisms of development of dyslipidemia in patients after liver transplantation. The authors integrate data from domestic and foreign literature about priorities of choice of lipid-lowering drugs and possible changes in patterns of immunosuppressive drug therapy to reduce the risk of onset and progression of cardiovascular disease in patients who were underwent orthotopic liver transplantation.