Vol 17, No 1 (2015)
Articles
Arterial hypertension and cognitive function
Abstract
The article presents the definition, classification and pathogenetic mechanisms of cognitive impairment in patients with arterial hypertension (AH). Discusses the literature on the relationship of hypertension with risk of dementia. The possibilities of antihypertensive therapy in the prevention of dementia. Discussed in detail the results of the study Syst-Eur (Systolic Hypertension in Europe), in which the calcium antagonist (CA) nitrendipine ± enalapril reduced the risk of developing dementia, including Alzheimer's disease, new cases, 50%. Neuroprotective action mechanisms are considered as a whole and AK nitrendipine in particular.
Consilium Medicum. 2015;17(1):6-10






Efficacy and safety in clinical practice fosinopril
Abstract
Diseases of the cardiovascular system, including the leading place is occupied arterial hypertension (AH), making the most significant contribution to the statistics of fatal and disabling complications in the industrialized world, including in Russia. For the treatment of hypertension, according to domestic and European recommendations, 5 main groups of drugs, are applied including a significant role for blockers of the renin-angiotensin-aldosterone system. Among the angiotensin converting enzyme inhibitors deserved place on clinical effectiveness, organo properties and safety profile belongs fosinopril - lipophilic drug with a dual route of elimination. These properties fosinopril have sufficient evidentiary basis, and despite the large variety of drugs in this group, fosinopril has its own niche in the treatment of hypertensive patients, including those with concomitant chronic kidney disease, chronic heart failure, and has future prospects.
Consilium Medicum. 2015;17(1):18-21



Acetylsalicylic acid in hypertensive patients at high risk
Abstract
The following review discusses the efficacy of aspirin in hypertensive patients at high risk for primary prevention of cardiovascular disease. Considered in detail are the results of the study of NOT, performed in hypertensive patients and the benefits of low-dose aspirin versus placebo for the primary prevention of myocardial infarction and reduce the incidence of the combined endpoint (myocardial infarction, stroke, cardiovascular death) are presented.
Consilium Medicum. 2015;17(1):22-26






Aggravation of coronary heart disease: the balance of risk and the risk of disease treatment
Abstract
This review describes current approaches to the treatment of patients who have had an episode of acute ischemic heart disease. Summarizes studies of oral direct inhibitors of hemostasis in this pathology. The only drug of this group rivaroxaban, despite a slight increase in the frequency of bleeding, has demonstrated efficacy in reducing total mortality in thesepatients. Particular attention is given today interventional procedures, which may also serve as a source of additional problems, especially stent thrombosis. Rivaroxaban has proved effective in reducing the frequency of this complication.
Consilium Medicum. 2015;17(1):30-35



Prehospital appointment of ticagrelor in patients with myocardial infarction and ST segment elevation (abstract)
Abstract
Материал подготовлен А.Л.Комаровым (д-р мед. наук, вед. науч. сотр. лаб. атеротромбоза НИИ кардиологии ФГБУ РКНПК) и О.О.Шахматовой (канд. мед. наук, мл. науч. сотр. лаб. атеротромбоза НИИ кардиологии ФГБУ РКНПК) по статье Montalescot G, van't Hof AW, Lapostolle F et al. Prehospital ticagrelor in ST -segment elevation myocardial infarction. N Engl J Med 2014; 371: 1016-27
Consilium Medicum. 2015;17(1):36-40



Prospects for personalized utilization of non-vitamin K anticoagulants based on the assessment of pharmacokinetics in patients with atrial fibrillation
Abstract
The article is devoted to the actual problem of non-vitamin K anticoagulants application (NOAC) for secondary stroke prevention in patients with atrial fibrillation. Therapeutic drug monitoring is considered a promising tool for personalized anticoagulation that allows to prevent the development of complications associated with NOAC administration.
Consilium Medicum. 2015;17(1):41-43



Approaches to the choice of a statin to treat patients on an outpatient basis
Abstract
The paper presents an algorithm of examination of the patient to decide on the appointment of statins for the treatment of dyslipidemia and atherosclerosis. The criteria of the effectiveness of statin therapy. The advantages of atorvastatin and rosuvastatin. We discuss the choice of a statin for the treatment of selected patients with changes in blood lipid spectrum.
Consilium Medicum. 2015;17(1):44-49



Safety monitoring of medicines in health facilities: problems and perspective of development
Abstract
Legislation in the field of drugs in the Russian Federation fixed responsibility of health professionals to identify, register, timely informing regulators of cases of adverse drug reactions. Despite the improvement of the pharmacovigilance system in Russia, the activity of health professionals to monitor the efficacy and safety of the drugs remains low. The article presents guidelines for creating at medical institutions effective pharmacovigilance system.
Consilium Medicum. 2015;17(1):50-53



Lifestyle modification, training and self-control as important components of diabetes treatment and improvement of patients life quality
Abstract
The article deals with the problem of lifestyle modification in patients with diabetes mellitus, the connection between type 2 diabetes and cardiovascular disease, the causes of unsatisfactory noncompliance many patients with diabetes with regard to lifestyle changes and recommended medical treatment. The role of health professionals in the treatment of patients, the value of structured training programs for the treatment of type 2 diabetes patients is emphasized the need for education in schools diabetic patients, the importance of self-control and an individual approach to each patient specialists to improve the quality of life.
Consilium Medicum. 2015;17(1):54-62



Differential diagnosis of chest pain: in focus digestive diseases
Abstract
The problem of proper diagnostic interpretation of chest pain is one of the most complex and urgent internal diseases. The article describes the features of pain in various diseases of the digestive system, covered issues of diagnosis and differential diagnosis.
Consilium Medicum. 2015;17(1):63-67



Iatrogenic risk factors and correction of dyslipidemia after liver transplantation
Abstract
The article analyzes information of the prevalence, causes and mechanisms of development of dyslipidemia in patients after liver transplantation. The authors integrate data from domestic and foreign literature about priorities of choice of lipid-lowering drugs and possible changes in patterns of immunosuppressive drug therapy to reduce the risk of onset and progression of cardiovascular disease in patients who were underwent orthotopic liver transplantation.
Consilium Medicum. 2015;17(1):68-71



PEGASUS-TIMI study 54 demonstrated that long-term use of the drug ticagrelor therapy in patients with myocardial infarction (over a year ago), leads to reduce the incidence of thrombotic complications
Consilium Medicum. 2015;17(1):72


